Assessment of aflatoxin M1 contamination in the milk of four dairy species in Croatia

Bilandžić, Nina; Božić, Đurđica; Đokić, Mаја; Sedak, Marija; Kolanović, Božica Solomun; Varenina, Ivana; Cvetnić, Željko

doi:10.1016/j.foodcont.2014.02.044

Cited by 65 publications

(35 citation statements)

References 23 publications

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“…Aflatoxin B1 can be characterized as the most toxic since it is a mutagen, and has a teratogenic and cancerogenic effect. It can be classified as the first category of the human cancerogenic materials [49]. After the consummation of aflatoxin-contaminated feeds, aflatoxin B1 is being metabolically transformed into a hydroxylated form aflatoxin M1 [42].…”

Section: Mycotoxin Contaminationmentioning

confidence: 99%

“…This form can be detected in milk after the ingestion of feed contaminated with aflatoxin B1 [50]. Compared to aflatoxin B1, aflatoxin M1 has approximately a ten times lower cancerogenic effect [49]. The maximum allowed concentration of aflatoxin M1 in milk in the Republic of Serbia at the moment is 0.250 μg/kg, while in the past this value was 0.5 μg/kg.…”

Section: Mycotoxin Contaminationmentioning

confidence: 99%

“…Fumonisin is constituted of two hydrophilic chains connected with ester bonds to one aliphatic chain with 20 C atoms. It is usually produced by F. vertialliaides, F. moniliforme and F. proliferatium [40,49,58] and in smaller percent by A. niger [59].…”

Section: Fumonisinsmentioning

confidence: 99%

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A review of the presence of some food contaminants on the territory of the Republic of Serbia

Danilović¹,

Potić²,

Stamenković³

et al. 2017

Adv Techol

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Food contamination is one of the major problems in food distribution. Microorganisms and their metabolites are the most common food contaminants. This review consolidates the reported food contamination cases in the Republic of Serbia. Mycotoxins were stated as the most common contaminants in various foods. Among them mycotoxins like zearalenone, aflatoxins, fumonisins, and deoxynivalenol were the most frequently detected. Also, the contamination caused by the presence of various microorganisms like L. monocytogenes, E. coli, Salmonella spp. and S. aureus was reported in high frequency. The microbial contamination was usually detected in meat and dairy products. Although heavy metals were detected in some products, in most cases their concentrations were in accordance with the legislation. A higher level of Pb and Hg was stated only in a few samples of tea, milk and fish. The constant analysis, control and prevention are needed at all levels of the production in order to compile the safety requirements and international legislation.

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Section: Mycotoxin Contaminationmentioning

confidence: 99%

Section: Mycotoxin Contaminationmentioning

confidence: 99%

See 1 more Smart Citation

A review of the presence of some food contaminants on the territory of the Republic of Serbia

Danilović¹,

Potić²,

Stamenković³

et al. 2017

Adv Techol

View full text Add to dashboard Cite

show abstract

“…Outbreaks of aflatoxicosis in SubSaharian Africa have led to hundreds of fatalities, even recent years [16,17]. On the other side, frequent outbreaks of aflatoxins in Europe over the last decade have mainly shown their impact on animal health, with serious implication on milk and dairy sector in Mediterranean and Balkan area [18,19].…”

Section: Mycotoxins In Food Commoditiesmentioning

confidence: 99%

Mycotoxins and Nuclear Receptors: A Still Underexplored Issue

Dall’Asta¹

2016

Nuclear Receptor Research

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Abstract.Mycotoxins are fungal secondary metabolites that can be found in food commodities worldwide. They exert a wide range of adverse effects towards humans and animals. Although toxicological studies have addressed these food contaminants over decades, their mode of actions as well as their synergistic effects are still to be deeply clarified. Among the toxicological targets, nuclear receptors have been identified by several studies. Besides the estrogenic effect, a wider range of endocrine and neuroendocrine disrupting effects have been reported so far. This review is aimed at addressing the recent advances in toxicology, and at highlighting possible gaps of knowledge.

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“…Depending on the level of feed contamination, approximately 0.3-6.3% of AFB1 ingested by livestock is transformed to AFM1 in milk (Prandini et al, 2008;Kabak, 2012). The AM1 has been detected in the milk of cows, sheep, goats, buffalos, camels and women (Galvano et al, 1996;Duarte et al, 2013;Bilandzic et al, 2014).…”

mentioning

confidence: 99%

Aflatoxin M1 levels in sow milk

Prodanov-Radulović

Baloš

Jakšić

et al. 2018

J Hellenic Vet Med Soc

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ABSTRACT. Aflatoxins (AFs) are one of the most known and investigated group of mycotoxins, which can be found as contaminants in different types of food and feed. Animals are exposed to AFs mainly through the consumption of contaminated feed, particularly products of plant origin. Among AFs, aflatoxin M1 (AFM1) is the monohydroxylated derivative of AFB1 formed in the liver and excreted into the milk of lactating animals. This study encompassed the Vojvodina region of Serbia and was aimed at determining the levels of AFM1 excretion in sows' milk in the first 3-5 days of lactation, after consumption of naturally contaminated with AFB1 maize. A total of 110 sows' milk samples from 11 swine farms in the specific region were analyzed by Enzyme Linked Immunosorbent Assay (ELISA). Different levels of AFM1 were detected in the majority (97%) of the examined milk samples. The obtained results showed AFM1 levels ranging from 5 to 165.4 ng/L. The results of this study pose special health concern associated with aflatoxin contamination of swine feed raw materials in this particular part of Serbia. Moreover, such high incidence of AFM1 detection in sows' milk may suggest the occurrence of long-term low level aflatoxicosis clinical cases.

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Assessment of aflatoxin M1 contamination in the milk of four dairy species in Croatia

Cited by 65 publications

References 23 publications

A review of the presence of some food contaminants on the territory of the Republic of Serbia

A review of the presence of some food contaminants on the territory of the Republic of Serbia

Mycotoxins and Nuclear Receptors: A Still Underexplored Issue

Aflatoxin M1 levels in sow milk

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