Assessment of adverse reactions to α-lipoic acid containing dietary supplements through spontaneous reporting systems

Gatti, Milo; Ippoliti, Ilaria; Poluzzi, Elisabetta; Antonazzo, Ippazio Cosimo; Moro, Paola Angela; Moretti, Ugo; Menniti‐Ippolito, Francesca; Mazzanti, Gabriela; Ponti, Fabrizio De; Raschi, Emanuel

doi:10.1016/j.clnu.2020.07.028

Cited by 21 publications

(13 citation statements)

References 51 publications

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“…36,101 Consistently, in patients with diabetic polyneuropathy or other CNS diseases, few AEs were found, and some studies did not set AEs as an endpoint. [102][103][104] Consistent with our results, a meta-analysis including 71 placebo-controlled clinical studies found that LA was associated with no increased risk of AEs, even with pregnancy status. 105 For future studies, seeking the balance of effective dose and fewer AEs will be necessary.…”

Section: La Efficacy and Safetysupporting

confidence: 89%

Role of lipoic acid in multiple sclerosis

et al. 2021

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Multiple sclerosis (MS) is a disabling autoimmune disease of the central nervous system (CNS) characterized by demyelination and neurodegeneration. 1 It affects approximately 2.5 million people worldwide and poses a growing burden to society. 2,3 Relapsing-remitting MS (RRMS) is the most common initial course featuring alternate relapse and remission, and disability is aggravated gradually with illness development. 4 After approximately 20 years, around 90% of RRMS patients will develop secondary progressive MS (SPMS) characterized by progressive neurodegeneration without any definite remission periods. 5,6 In addition to SPMS, progressive MS (PMS) also includes

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Section: La Efficacy and Safetysupporting

confidence: 89%

Role of lipoic acid in multiple sclerosis

et al. 2021

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“…The α‐LA was well‐tolerated, and its side effects were rare. However, some side effects of α‐LA include the onset of insulin autoimmune syndrome (IAS) (Takeuchi, Miyamoto, Kakizawa, Shigematsu, & Hashizume, 2007), skin rash, and gastrointestinal disorders (Gatti et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review

Najafi

Mehri

Rahbardar

2022

Phytotherapy Research

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Metabolic syndrome (MetS) is a multifactorial disease with medical conditions such as hypertension, diabetes, obesity, dyslipidemia, and insulin resistance. Alpha-lipoic acid (α-LA) possesses various pharmacological effects, including antidiabetic, antiobesity, hypotensive, and hypolipidemia actions. It exhibits reactive oxygen species scavenger properties against oxidation and age-related inflammation and refines MetS components. Also, α-LA activates the 5 0 adenosine monophosphate-activated protein kinase and inhibits the NFκb. It can decrease cholesterol biosynthesis, fatty acid β-oxidation, and vascular stiffness. α-LA decreases lipogenesis, cholesterol biosynthesis, low-density lipoprotein and very low-density lipoprotein levels, and atherosclerosis. Moreover, α-LA increases insulin secretion, glucose transport, and insulin sensitivity. These changes occur via PI3K/Akt activation. On the other hand, α-LA treats central obesity by increasing adiponectin levels and mitochondrial biogenesis and can reduce food intake mainly by SIRT1 stimulation. In this review, the most relevant articles have been discussed to determine the effects of α-LA on different components of MetS with a special focus on different molecular mechanisms behind these effects. This review exhibits the potential properties of α-LA in managing MetS; however, high-quality studies are needed to confirm the clinical efficacy of α-LA.

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“…ALA has often been used as a dietary supplement and antiageing agent in Japan since June 2004 15 . However, ALA‐containing products are marketed as dietary supplements instead of ALA‐containing drugs in most European countries (except Germany) 16 . According to statistics, approximately half of US adults and one‐third of children use dietary supplements in general 17 .…”

Section: Discussionmentioning

confidence: 99%

“…Continued) drugs in most European countries (except Germany) 16. According to statistics, approximately half of US adults and one-third of children use dietary supplements in general 17.…”

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confidence: 99%

Analysis of the clinical characteristics of insulin autoimmune syndrome induced by alpha‐lipoic acid

et al. 2021

J Clin Pharm Ther

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What is known and objective: Alpha-lipoic acid (ALA) is widely used as a dietary supplement and antiageing agent. Insulin autoimmune syndrome (IAS) is the most serious adverse reaction reported with the use of ALA. The purpose of this study was to explore the clinical characteristics of ALA-induced IAS and provide a scientific reference for clinical diagnosis, treatment and prevention.Methods: We collected literature on IAS cases induced by ALA for retrospective analysis in Chinese and English. Results and discussion:The median age of 37 patients (28 females and 9 males) was

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Assessment of adverse reactions to α-lipoic acid containing dietary supplements through spontaneous reporting systems

Cited by 21 publications

References 51 publications

Role of lipoic acid in multiple sclerosis

Role of lipoic acid in multiple sclerosis

Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review

Analysis of the clinical characteristics of insulin autoimmune syndrome induced by alpha‐lipoic acid

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