2024
DOI: 10.22141/2224-0721.19.8.2023.1339
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Assessment of adenohypophysis function and ghrelin level in children with biologically inactive growth hormone syndrome

N.A. Sprynchuk,
Yu.V. Marushko,
T.M. Malinovska

Abstract: Background. Mutations in the growth hormone (GH) gene cause various forms of biologically inactive growth hormone (BIGH) syndrome. Ghrelin potentiates the secretion of GH. Ade­nohypophysis hormones take part in human growth mechanisms. Insulin-like growth factor 1 (IGF-1) level is a criterion of GH activity. The purpose of the study was to assess the adenohypo­physis functions and to determine the role of ghrelin in patients with BIGH syndrome to optimize the diagnosis and treatment. Materials and methods. Ant… Show more

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