Assessment of Acute Renal Transplant Rejection with Blood Oxygen Level–Dependent MR Imaging: Initial Experience

Sadowski, Elizabeth A.; Fain, Sean B.; Alford, Sara K.; Korosec, Frank R.; Fine, Jason P.; Muehrer, Rebecca J.; Djamali, Arjang; Hofmann, Robert; Becker, Bryan N.; Grist, Thomas M.

doi:10.1148/radiol.2363041080

Cited by 129 publications

(92 citation statements)

References 25 publications

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“…Sadowski and coworkers reported BOLD MRI measurements in kidney allografts with ATN (n=4-6) within 4 months post-transplantation. [64][65][66] There was no significant difference in cortical oxygenation in the ATN group compared with normal functioning allografts, although one study showed a trend toward cortical hypoxia. Medullary oxygenation was significantly increased in the ATN group in one study, but not in the other two.…”

Section: Acute Tubular Necrosismentioning

confidence: 94%

“…[64][65][66][67]79,80 In three separate publications, Djamali et al 64 and Sadowski et al 65,66 found that within the first 4 months after renal transplantation, acute rejection (n=8-13) was associated with increased renal medullary oxygenation, despite reduced medullary blood flow, as compared with both normally functioning allografts and allografts with ATN. Cortical oxygenation was similar in all groups.…”

Section: Kidney Transplantationmentioning

confidence: 99%

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Blood oxygenation level-dependent MRI for assessment of renal oxygenation

Neugarten¹,

Golestaneh²

2014

IJNRD

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Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) has recently emerged as an important noninvasive technique to assess intrarenal oxygenation under physiologic and pathophysiologic conditions. Although this tool represents a major addition to our armamentarium of methodologies to investigate the role of hypoxia in the pathogenesis of acute kidney injury and progressive chronic kidney disease, numerous technical limitations confound interpretation of data derived from this approach. BOLD MRI has been utilized to assess intrarenal oxygenation in numerous experimental models of kidney disease and in human subjects with diabetic and nondiabetic chronic kidney disease, acute kidney injury, renal allograft rejection, contrast-associated nephropathy, and obstructive uropathy. However, confidence in conclusions based on data derived from BOLD MRI measurements will require continuing advances and technical refinements in the use of this technique.

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Section: Acute Tubular Necrosismentioning

confidence: 94%

Section: Kidney Transplantationmentioning

confidence: 99%

Blood oxygenation level-dependent MRI for assessment of renal oxygenation

Neugarten¹,

Golestaneh²

2014

IJNRD

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“…There have been studies using blood oxygenation level-dependent magnetic resonance imaging in experimental ischemic AKI and clinical settings, including allograft rejection compared with normal functional transplants and transplants with acute tubular necrosis. [9][10][11] Other noninvasive tools that are potential candidates for assessing RBF and tissue oxygenation include positron emission tomography and optical spectroscopy, 12,13 both of which need validation in additional clinical studies.…”

Section: Methodsmentioning

confidence: 99%

Targeting Endogenous Repair Pathways after AKI

Humphreys

Cantaluppi

Portilla

et al. 2016

Journal of the American Society of Nephrology

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AKI remains a highly prevalent disease associated with poor short-and long-term outcomes and high costs. Although significant advances in our understanding of repair after AKI have been made over the last 5 years, this knowledge has not yet been translated into new AKI therapies. A consensus conference held by the Acute Dialysis Quality Initiative was convened in April of 2014 and reviewed new evidence on successful kidney repair to identify the most promising pathways that could be translated into new treatments. In this paper, we provide a summary of current knowledge regarding successful kidney repair and offer a framework for conceptualizing the therapeutic targeting that may facilitate this process. We outline gaps in knowledge and suggest a research agenda to more efficiently bring new discoveries regarding repair after AKI to the clinic.

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“…6) may be an indicator of acute rejection. Further support for this consideration comes from the finding that functional T2-mapping (BOLD) MRI has been shown to differentiate ATN and acute rejection (27,57).…”

Section: Acute Rejectionmentioning

confidence: 99%

Kidney transplantation: Structural and functional evaluation using MR Nephro‐Urography

Kalb

Martín

Salman

et al. 2008

Magnetic Resonance Imaging

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End-stage-renal disease (ESRD) is a major health issue in the United States, and the Medicare costs of ESRD totaled nearly $21 billion in 2005. Renal transplantation has emerged as the treatment of choice in this patient population, providing improved quality of life and lower healthcare costs compared with other treatment options. Imaging evaluation of a graft kidney plays a critical role in the postoperative care of the renal transplant patient. In the past, diagnostic evaluation of the transplant kidney has depended upon a combination of ultrasonography, computed tomography, MRI, and biopsy, used in conjunction with the patient's clinical presentation. However, new and developing advances in MR technology has lead to the development of MR Nephro-Urography (MRNU), which provides both anatomic and functional evaluation of the kidney in a single examination. It is expected that the increasing use of MRNU will have a significant impact on the management of renal transplant patients. This review describes MRNU methodology, examines known posttransplant complications, and highlights the utility of MRNU as a comprehensive imaging examination to diagnose both surgical and medical complications of the transplant kidney.

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Assessment of Acute Renal Transplant Rejection with Blood Oxygen Level–Dependent MR Imaging: Initial Experience

Cited by 129 publications

References 25 publications

Blood oxygenation level-dependent MRI for assessment of renal oxygenation

Blood oxygenation level-dependent MRI for assessment of renal oxygenation

Targeting Endogenous Repair Pathways after AKI

Kidney transplantation: Structural and functional evaluation using MR Nephro‐Urography

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