Assessment of acute moderate hyperglycemia on traditional and thromboelastometry coagulation parameters in healthy adult horses

McGovern, Kate; Lascola, Kara M.; Smith, Stephanie A.; Clark‐Price, Stuart C.; McMichael, Maureen; Wilkins, Pamela A.

doi:10.1111/j.1476-4431.2012.00792.x

Cited by 7 publications

(19 citation statements)

References 67 publications

(115 reference statements)

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“…In an animal study, acute moderate hyperglycemia (10.0–13.3 mmol/L) maintained for 6 hours did not show a detectable influence on blood coagulation as measured by ROTEM. [25] In an in vivo study, platelets and endothelial cells were not activated during 6 hours of hyperglycemia with concentrations of 11.1 and 16.7 mmol/L in healthy volunteers. [26] In contrast, hyperglycemia produced increases in tissue factor procoagulant and platelet activity in healthy volunteers.…”

Section: Discussionmentioning

confidence: 99%

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The effect of hyperglycemia on blood coagulation

Shin

Lee

et al. 2016

Medicine

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We performed a study to investigate whether contamination of hemostasis samples with a glucose-containing solution might generate spurious results in rotational thromboelastometry (ROTEM) tests.Venous blood was taken from 12 healthy volunteers and divided into 4 specimen bottles, which were contaminated with different concentrations (0%, 5%, 10%, and 20%) of glucose solution.Significant lengthening of INTEMCT was observed in the 10% and 20% groups compared with baseline values (7.7% and 9%, P = 0.041 and P = 0.037, respectively). INTEMCFT increased by 20.1% in the 20% group (P = 0.005). INTEMα-angle and INTEMMCF decreased by 3.9% and 2.7%, respectively, in the 20% group (P = 0.010 and P = 0.049, respectively). EXTEMCFT was prolonged significantly, by 10.2%, 15.5%, and 25.6%, in the 5%, 10%, and 20% groups, respectively (P = 0.004, P < 0.001, and P < 0.001, respectively). EXTEMα-angle decreased significantly by 1.9%, 3.2%, and 4.0% in the 5%, 10%, and 20% groups, respectively (P = 0.014, P = 0.001, and P = 0.005, respectively). EXTEMMCF decreased by 3.4% in the 20% group (P = 0.023). FIBTEMMCF decreased by 9.2% and 17.5% in the 10% and 20% groups, respectively (P = 0.019 and P = 0.021, respectively). A significant correlation was observed between standard glucose solution contamination in the specimens and percentage variation of EXTEMCFT, EXTEMMCF, and FIBTEMMCF.To obtain accurate data from the ROTEM test regarding the hemostatic status of patients, specimens with suspected or known contamination should not be analyzed.

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Section: Discussionmentioning

confidence: 99%

“…In contrast, other studies were performed about 6 or 24 hours after the hyperglycemic condition. [25–27] Therefore, there is a possibility that our study may not reflect the glucose effect on the coagulation cascade during 6 or 24 hours. Second, we evaluated only the hyperglycemic effect on blood coagulation.…”

Section: Discussionmentioning

confidence: 99%

The effect of hyperglycemia on blood coagulation

Shin

Lee

et al. 2016

Medicine

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“…Three hours before study onset, catheters (14 gauge 5.25 inch) were placed aseptically in both jugular veins, 1 for glucose and insulin sample collection, and 1 for endotoxin and dextrose infusion. A 3‐hour time lapse was allowed between catheter placement and study initiation because a previous study showed that placement of jugular catheters caused a transient increase in TAT . Baseline blood samples were collected immediately before initiation of infusions.…”

Section: Methodsmentioning

confidence: 99%

“…Methods for initiation and maintenance of controlled hyperglycemia in the GLU‐LPS group were identical to those previously described . A 50% dextrose solution was diluted in saline to obtain a 20% solution.…”

Section: Methodsmentioning

confidence: 99%

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The Effects of Hyperglycemia and Endotoxemia on Coagulation Parameters in Healthy Adult Horses

McGovern

Lascola

Smith

et al. 2013

Veterinary Internal Medicne

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Background: Hyperglycemia and endotoxemia have been associated with coagulation abnormalities in horses. Studies in humans suggest greater disturbances in coagulation with hyperglycemia and concurrent endotoxemia.Objectives: To compare coagulation parameters in horses administered with lipopolysaccharide (LPS) with and without concurrent hyperglycemia.Animals: Twelve healthy adult horses. Methods: Hyperglycemia (180-240 mg/dL) was maintained for 6 hours in 6 horses (GLU-LPS) using 140 mg/kg IV bolus of dextrose followed by a 20% dextrose constant rate infusion. A similar volume of saline was administered to an additional 6 horses (SAL-LPS). LPS (20 ng/kg) was administered to each horse. Fibrogen concentration, prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin antithrombin concentration (TAT), and thromboelastometry were measured at baseline and after 1, 1.5, 2, 2.5, 3, 4, 6, and 22 hours. Repeated measures analysis of variance was used to examine temporal changes.Results: Increases in PT (P = .001) and TAT (P = .027) were observed in the GLU-LPS group. Changes in thromboelastometry parameters including increased clot formation time (In-TEM, P = .006; Ex-TEM, P = .002) and decreased alpha angle (Ex-TEM, P = .04) and maximal clot firmness (Ex-TEM, P = .014) were observed in the SAL-LPS group. Differences between SAL-LPS and GLU-LPS groups were limited to increased maximal clot firmness (Ex-TEM) at 3, 6, and 22 hours (P < .001) in the SAL-LPS group.Conclusions and Clinical Importance: Minor alterations in coagulation parameters identified for each group are most likely not clinically relevant. Observed differences between groups do not suggest that concurrent hyperglycemia and endotoxemia are associated with greater coagulation abnormalities in horses.

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Cutaneous Vasculopathy and Pulmonary Thromboembolism in an Unstable Diabetic Cat

Manson

Woods

Morrison

et al. 2021

Topics in Companion Animal Medicine

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Assessment of acute moderate hyperglycemia on traditional and thromboelastometry coagulation parameters in healthy adult horses

Abstract: Acute, moderate hyperglycemia in healthy adult horses does not have a detectable effect on coagulation based on evaluated parameters. Jugular catheter placement results in a transient increase in thrombin generation as determined by increased TAT concentrations.

Cited by 7 publications

References 67 publications

The effect of hyperglycemia on blood coagulation

The effect of hyperglycemia on blood coagulation

The Effects of Hyperglycemia and Endotoxemia on Coagulation Parameters in Healthy Adult Horses

Cutaneous Vasculopathy and Pulmonary Thromboembolism in an Unstable Diabetic Cat

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