“…Moreover, it was shown that chloride availability in the renal tubules can modulate renal vasoactivity; low chloride perfusion of diminishes tubular response to vasopressors (Quilley et al, 1993). In line with those observations, more recent clinical studies have suggested that high chloride load could be associated with an increased risk of acute kidney injury (Sigmon et al, 2019;Yunos et al, 2012). Therefore, it is conceivable that various biological impacts of serum or tubular concentrations of chloride represent a less well known territory with potential clinical implications.…”