Assessment of acute and chronic morphine dependence in male and female mice

Kest, Benjamin; Palmese, Christina A.; Hopkins, Eileen; Adler, Michael; Juni, Aaron

doi:10.1016/s0091-3057(01)00600-1

Cited by 67 publications

(69 citation statements)

References 31 publications

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“…Among withdrawal measures, only the jumping response-defined as the simultaneous removal of all four paws from the horizontal surface-was consistently observed and found to be dose-dependent in previous studies of both acute and chronic morphine dependence (Smits, 1975;El-Kadi and Sharif, 1994;Kest et al 2001). Thus, although symptoms such as diarrhea, ptosis, wet-dog shakes, lacrimation were occasionally observed in the present study, they were excluded from analysis.…”

Section: Naloxone-precipitated Withdrawalsupporting

confidence: 47%

“…For narcotic drug abusing populations, the aversive withdrawal symptomology is regarded as a causative factor in their continued opioid use, engendering dangerous drug seeking behavior (Jasinski, 1977). Although physical dependence is commonly associated with chronic opioid intake, acute opioid treatment comprised of even a single exposure can cause dependence in a wide variety of species (Smits, 1975;Jasinski, 1977;McLemore et al 1997;Kest et al 2001). Despite their qualitatively similar withdrawal symptoms, there is behavioral and biochemical evidence that acute and chronic dependence are mediated by distinct mechanisms (Nehmad et al 1982;McLemore et al 1997;Kest et al 2001).…”

Section: Introductionmentioning

confidence: 99%

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Acute and chronic heroin dependence in mice: Contribution of opioid and excitatory amino acid receptors

Klein

Juni

Arout

et al. 2008

European Journal of Pharmacology

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Opioid and excitatory amino acid receptors contribute to morphine dependence, but there are no studies of their role in heroin dependence. Thus, mice injected with acute or chronic heroin doses in the present study were pretreated with one of the following selective antagonists: 7-benzylidenenaltrexone (BNTX), naltriben (NTB), nor-binaltorphimine (nor-BNI; δ 1 , δ 2 , and κ opioid receptors, respectively), MK-801, or LY293558 (NMDA and AMPA excitatory amino acid receptors, respectively). Naloxone-precipitated withdrawal jumping frequency, shown here to be a reliable index of heroin dependence magnitude, was reduced by BNTX or NTB in mice injected with both acute and chronic heroin doses. In contrast, nor-BNI did not alter jumping frequencies in mice injected with an acute heroin dose but significantly increased them in mice receiving chronic heroin injections. Continuous MK-801 or LY293558 infusion, but not injection, reduced jumping frequencies during withdrawal from acute heroin treatment. Their delivery by injection was nonetheless effective against chronic heroin dependence, suggesting mechanisms not simply attributable to NMDA or AMPA blockade. These data indicate that whereas δ 1 , δ 2 , NMDA, and AMPA receptors enable acute and chronic heroin dependence, κ receptor activity limits the dependence liability of chronic heroin. With the exception of δ 1 receptors, the apparent role of these receptors to heroin dependence is consistent with their contribution to morphine dependence, indicating that there is substantial physiological commonality underlying dependence to both heroin and morphine. The ability of κ receptor blockade to differentially alter acute and chronic dependence supports previous assertions from studies with other opioids that acute an chronic opioid dependence are, at least in part, mechanistically distinct. Elucidating the substrates contributing to heroin dependence, and identifying their similarities and differences with those of other opioids such as morphine, may yield effective treatment strategies to the problem of heroin dependency.

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Section: Naloxone-precipitated Withdrawalsupporting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Acute and chronic heroin dependence in mice: Contribution of opioid and excitatory amino acid receptors

Klein

Juni

Arout

et al. 2008

European Journal of Pharmacology

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“…It has been suggested that frequency is the most important factor (29). In studies with daily morphine injections, animals receive each dose at equal (6,18,25,30) or unequal dosing intervals (6,13,15,31). In the present study, animals were given intermittent morphine injections with different interdose intervals for a better assessment of spontaneous withdrawal associated to the treatment regimen.…”

Section: Discussionmentioning

confidence: 93%

“…Weight loss and jumping are considered predominant signs for quantification of naloxone withdrawal in both rats (33,34) and mice (6,11,35). Accordingly, naloxone precipitated withdrawal weight loss and jumping in morphine-treated male and female rats (Figures 1 and 2).…”

Section: Discussionmentioning

confidence: 95%

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Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences

ALLAHVERDİYEV¹,

TÜRKMEN²,

NURTEN³

et al. 2015

Turk J Med Sci

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Background/aim: Treating animals repeatedly with intermittent and increasing morphine doses has been suggested to allow some withdrawal during each dosing interval, which causes repeated stress. The present study aimed to test this hypothesis and assess sexrelated differences in withdrawal signs and their suppression by clonidine.Materials and methods: Male and female rats and mice were administered with increasing doses of morphine twice daily at different dosing intervals. Rats were given clonidine in drinking water (5 µg/mL). Spontaneous and naloxone-precipitated withdrawal signs and novelty-induced grooming were evaluated.Results: Male rats and male and female rats displayed manifestations of morphine withdrawal at the end of 14-h and 24-h dosing intervals, respectively. Clonidine attenuated the severity of the withdrawal signs. Male but not female mice displayed withdrawal signs at the end of 12-h and 17-h dosing intervals. Female mice exhibited less pronounced naloxone-precipitated withdrawal syndrome. Grooming did not reflect a "stress-like state" in morphine-treated animals. Conclusion:These findings indicate intermittent morphine treatment-induced spontaneous withdrawal in rats and mice and sexrelated differences in spontaneous and naloxone-precipitated withdrawal signs in mice. Since the treatment protocol closely parallels the drug use pattern in opioid addicts, further experiments are needed to clarify the stress associated with the treatment and the efficacy of sedatives.

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The novel depot of buprenorphine propionate has a long‐acting effect on physical dependence on morphine

Liu

Lin

Shieh

et al. 2006

Drug Development Research

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Buprenorphine is a promising drug for the treatment of physical dependence on opioids. The aim of the present study was to evaluate the efficacy and duration of action of a novel depot form of a buprenorphine prodrug, buprenorphine propionate, on physical dependence on morphine. Following intramuscular injection in morphine-dependent mice, the efficacy and duration of action of buprenorphine propionate in sesame oil were evaluated. Two other dosage forms of buprenorphine were used as controls. Intramuscular injection of buprenorphine HCl (0.1 mmol/kg in saline) attenuated the severity of morphine dependence (Po0.05) with a 9-h duration of action. However, a further increase in dose up to 60-fold could not further increase its duration of action. On the other hand, buprenorphine base and propionate when prepared in sesame oil produced longer durations of action than did buprenorphine HCl in saline under an equimolar basis of 6 mmol/kg (Po0.05, for each comparison). Among dosage forms, buprenorphine propionate in sesame oil produced the longest duration of action, 11.3-fold longer than that of buprenorphine HCl in saline and 2-fold longer than buprenorphine base in oil. In conclusion, the novel depot of buprenorphine propionate produced a dose-related long-acting effect on physical dependence on morphine in mice. Drug Dev.

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Assessment of acute and chronic morphine dependence in male and female mice

Cited by 67 publications

References 31 publications

Acute and chronic heroin dependence in mice: Contribution of opioid and excitatory amino acid receptors

Acute and chronic heroin dependence in mice: Contribution of opioid and excitatory amino acid receptors

Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences

The novel depot of buprenorphine propionate has a long‐acting effect on physical dependence on morphine

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