Assessment of a Polyester-Covered Nitinol Stent in the Canine Aorta and Iliac Arteries

Castañeda, Flavio; Ball-Kell, Susan; Young, Kate; Li, Ruizong

doi:10.1007/s002700010087

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…Moreover, due to the healing process, there is some form of incorporation of polyester-or polytetrafluoroethylene-covered stents, which is not the case with polymer-filled endobags. 30,31 All this may lead to the formation of a tiny space between the inner wall of the aneurysmal neck and the endobag, which in turn may lead to a type I microendoleak not detectable by conventional imaging modalities that will pressurize the aneurysmal sack and lead to complications, such as aneurysm growth, rupture, and formation of an aorto-duodenal fistula. The finding of this study confirms the notion that there is something more beyond the diameter of the neck of AAA.…”

Section: Discussionmentioning

confidence: 99%

Mid-Term Results of Endovascular Aneurysm Sealing in the Treatment of Abdominal Aortic Aneurysm With Unfavorable Morphology

Dzieciuchowicz

Tomczak

Strauss

et al. 2020

Vasc Endovascular Surg

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Purpose: To report mid-term results of endovascular aneurysm sealing (EVAS) of abdominal aortic aneurysms (AAA) deemed unsuitable for a standard endovascular aneurysm repair (EVAR). Methods: A prospectively maintained database of 42 patients with EVAR-unfavorable anatomy treated by EVAS combined with chimney grafts in case of the proximal AAA neck shorter than 5 mm was analyzed. Early outcomes included final angiographic result, intra- and early post-operative deaths, and complications. Mid-term outcomes included all-cause mortality (ACM), aneurysm-related mortality (ARM), patency of the stents, occurrence of endoleaks, serious complications and graft failures defined as the AAA growth of more than 5 mm, type I endoleak, occlusion of the stent-graft or chimney graft, aorto-duodenal fistula, or aneurysm rupture. Results: The procedure was completed in all patients. Twenty-eight chimney grafts were implanted in 19 patients. Patients were followed for a median of 24 months (range 12-34 months). There were 2 intraoperative ruptures and 1 patient died in an early postoperative period. The cumulative ACM was 15, 21, and 36% at 12, 24, and 36 months, respectively, and the cumulative ARM was 8, 11, and 27% at 12, 24, and 36 months, respectively. Three out of 5 aneurysm-related deaths were due to a secondary aorto-duodenal fistula. The cumulative incidence of graft failure was 20, 27, and 42% at 12, 24, and 36 months, respectively. The cumulative incidence of an endoleak was 5, 9, and 23% at 12, 24, and 36 months, respectively. The graft failure increased significantly both ACM (p = .012) and ARM (p = .00003). The implantation of chimney grafts at the initial procedure increased ARM significantly (p = .008). The presence of an endoleak did not have any significant influence on ACM and ARM. Conclusion: Patients treated with EVAS for AAAs with EVAR-unfavorable anatomy, especially those with chimney grafts, exhibit a high risk of graft failure and subsequent death.

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Section: Discussionmentioning

confidence: 99%

Mid-Term Results of Endovascular Aneurysm Sealing in the Treatment of Abdominal Aortic Aneurysm With Unfavorable Morphology

Dzieciuchowicz

Tomczak

Strauss

et al. 2020

Vasc Endovascular Surg

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“…Because of limitations on studying diseases of aorta in humans, animals have become particularly important in vascular research and a large number of animal models have been developed. Some researchers have selected the canine model for studies because of its similar morphological features to humans (Chuter et al., 1997; Castaneda et al., 2000). For example, dogs have been used as models for coarctation (Uhari et al., 1983), aneurysm (Chuter et al., 1997), restenosis (Powers et al., 1999), haemodynamics (Wang et al., 2003) and vascular prostheses research (Onuki et al., 1997; Castaneda et al., 2000; Noishiki et al., 2000; Pitton et al., 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Some researchers have selected the canine model for studies because of its similar morphological features to humans (Chuter et al., 1997; Castaneda et al., 2000). For example, dogs have been used as models for coarctation (Uhari et al., 1983), aneurysm (Chuter et al., 1997), restenosis (Powers et al., 1999), haemodynamics (Wang et al., 2003) and vascular prostheses research (Onuki et al., 1997; Castaneda et al., 2000; Noishiki et al., 2000; Pitton et al., 2002). Some aortic diseases are also recognized in dogs (Kraus et al., 1986; Liu et al., 1986; Sottiaux, 1999; Boswood et al., 2000; Chetboul et al., 2003).…”

Section: Introductionmentioning

confidence: 99%

Normal Morphometry of the Thoracic Aorta in the German Shepherd Dog: a Computed Tomographic Study

Dabanoğlu¹

2006

Anat Histol Embryol

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Computed tomographic images of the thoracic aorta of 14 German shepherd dogs were examined in order to determine the morphometry of the thoracic aorta. Examinations were carried out in the transverse plane at both intervertebral and mid-vertebral levels of each thoracic vertebra between T(5) and T(13). The dorsoventral and transversal diameters as well as cross-section area of the thoracic aorta were measured. The widest transversal diameter was observed at T(4-5), whereas the largest dorsoventral diameter was detected at T(5). The maximum cross-section area was detected at T(4-5). When dorsoventral and transversal diameters were compared between males and females, the aortic diameter was found to be smaller in males than in females. Although the shape of the thoracic aorta was transversal oval in the majority of the examined females, the shape of the thoracic aorta was dorsoventral oval in the majority of the males. There were significant differences between all levels measured for transversal (P < 0.001), dorsoventral (P < 0.001) diameters and cross-section area (P < 0.001) of the thoracic aorta. And there was a significant correlation between the three parameters examined. However, the correlation coefficient was highest in females.

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Animal Study and Pre-clinical Trials of Biomaterials

Noviana

Estuningsih

Ulum

2016

Advanced Structured Materials

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An in vivo study is one of the most important steps in the process of translating biomaterials to clinical applications. It is mostly conducted to confirm in vitro results before going further to clinical trials. Appropriate use of animal models in the in vivo studies of biomaterials and medical devices is mandatory and should meet the approved regulations and ethics as defined by both local and international regulatory bodies. These studies involve the use of various approaches and protocols in order to know the body responses both local and systemic and to find out the short-and long-term responses of the body toward the implanted biomaterials or devices. This chapter describes complete procedures and practices of in vivo studies starting from selection of appropriate animal model, pre-implantation, surgical procedure and post-implantation, and monitoring of material-host responses. Some experiences of in vivo studies done by Indonesian researchers and the development of new implants are also presented.

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Assessment of a Polyester-Covered Nitinol Stent in the Canine Aorta and Iliac Arteries

Abstract: The covered stent demonstrated predictable healing and is effective in preventing stenosis in vessels 10.0 mm or greater in diameter but does not completely preclude stenosis in vessels 6.0 mm or less in diameter.

Cited by 3 publications

References 30 publications

Mid-Term Results of Endovascular Aneurysm Sealing in the Treatment of Abdominal Aortic Aneurysm With Unfavorable Morphology

Mid-Term Results of Endovascular Aneurysm Sealing in the Treatment of Abdominal Aortic Aneurysm With Unfavorable Morphology

Normal Morphometry of the Thoracic Aorta in the German Shepherd Dog: a Computed Tomographic Study

Animal Study and Pre-clinical Trials of Biomaterials

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