Assessment of a downsized potassium adsorption filter designed to transfuse neonates

Ogasawara, Kei; Ohto, Hitoshi; Takano, Nozomi; Nollet, Kenneth E.; Go, Hayato; Sato, Maki; Momoi, Nobuo

doi:10.1111/trf.16010

Cited by 2 publications

(1 citation statement)

References 18 publications

(25 reference statements)

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“…This is still in the experimental phase and the circuit requires heparinization. A simpler option may be an inline potassium filter for blood giving sets, which has proven effective in removing potassium from irradiated, older pRBCs [65,66]. These could be valuable if integrated into the blood spike lines of rapid infusion devices but may be hampered by limited effective flow rates.…”

Section: Extracorporeal Interventionsmentioning

confidence: 99%

Biochemical disturbance in damage control resuscitation: mechanisms, management and prognostic utility

Milne¹,

Radhakrishnan²

2022

Current Opinion in Anaesthesiology

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Purpose of reviewWith advances in resuscitative techniques, trauma patients are surviving increasingly severe injuries and physiological insult. Timely recognition of futility remains important in terms of patient dignity and resource preservation yet is increasingly challenging in the face of these advances. The understanding of biochemical derangement from pathophysiological processes of trauma and iatrogenic effects of resuscitation has expanded recently.Recent findingsAcidosis and hypocalcaemia have been recognized as important contributors to mortality among trauma patients. Although less well recognized and studied, critical injury and high blood product volume resuscitation render patients vulnerable to life-threatening hyperkalaemia. The methods of correcting disruptions to acid–base and electrolyte homeostasis during damage control resuscitation have changed little recently and often rely on evidence from undifferentiated populations. Biochemical disturbances have value as ancillary predictors of futility in trauma resuscitation.SummaryThese findings will contribute to a greater understanding among anaesthesiologists of the causative mechanisms and effects of biochemical derangement after severe injury and aid them in the delivery of well tolerated and effective damage control resuscitation. Gaps in the evidence base are highlighted to encourage future work.

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Section: Extracorporeal Interventionsmentioning

confidence: 99%