Assessment of a digital game as a neuropsychological test for postoperative cognitive dysfunction

Lucatelli, André; Goulart, Ananaira Alves; Silveira, Paulo Sérgio Panse; Siqueira, José de Oliveira; Carmona, Maria José Carvalho; Pereira, Vanessa Gonçalves; Valentin, Lívia Stocco Sanches; Vieira, Joaquim Edson

doi:10.1016/j.bjane.2021.06.025

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…Moreover, digital neurocognitive tests minimize administrative burden for health care professionals [ 21 ], and provide better diagnostic performance than analog ones [ 19 ]. To our knowledge, there is no digital version of the ISPOCD test battery available and a few earlier studies have used digital and analog cognitive tests in the surgical population [ 22 – 25 ], yet the choice of cognitive tests varies and none of them has been compared to the ISPOCD test battery [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Comparing analog and digital neurocognitive tests with older adults: a study of the ISPOCD battery vs. a digital test battery from Mindmore

Amirpour,

Eckerblad,

Bergman

et al. 2024

BMC Geriatr

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Background Delayed neurocognitive recovery and neurocognitive disorder are common postoperative complications among older adults. The assessment of these complications traditionally relies on analog neurocognitive tests, predominantly using the test battery from the ISPOCD-study as the standard approach. However, analog tests are time-consuming and necessitate trained staff which poses limitations. The potential availability of a digital neurocognitive test as an alternative to the ISPOCD remains unknown. We conducted a comparative study between the analog test battery from ISPOCD and the self-administrated digital test battery developed by Mindmore. Methods We conducted a crossover study with 50 cognitively healthy older adults ≥ 60 years of age recruited in Stockholm Sweden, between February and April 2022. The primary outcome focused on measuring comparability between the two test batteries. Our secondary outcomes included assessing participants’ perceptions and attitudes about the tests with qualitative interviews and their usability experiences. Results Fifty older adults, mean age 76, female 56%, with a university or college degree 48% participated in the study. The sub tests in two test batteries demonstrated a medium–large correlation (r = 0.3–0.5), except for one measure. For four out of six measures, significant differences were found with medium to large effect sizes, ranging from 0.57–1.43. Two categories were recognized in the qualitative analysis: self-competing in a safe environment, and experience with technology. Participants expressed feeling safe and at ease during the assessment, with some preferring the digital test over the analog. Participants reported a high level of usability with the digital test and a majority participants (n = 47) reported they would undergo the digital test for a potential future surgery. Conclusions The digital test battery developed by Mindmore offers several advantages, including rapid access to test results, easy comprehension, and use for participants, thereby increased accessibility of cognitive screening. Trial registration number NCT05253612; ClinicalTrials.gov, 24/02/2022.

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Section: Introductionmentioning

confidence: 99%

Comparing analog and digital neurocognitive tests with older adults: a study of the ISPOCD battery vs. a digital test battery from Mindmore

Amirpour,

Eckerblad,

Bergman

et al. 2024

BMC Geriatr

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“…[ 8 ] This condition is common in elderly postoperative patients, with a high incidence. [ 9 ] It can easily lead to Alzheimer’s disease if not treated in time, affecting the socialization and communication of patients after hospital discharge. [ 10 ] Existing research has shown that the depth of anesthesia has an impact on the incidence of postoperative POCD.…”

Section: Introductionmentioning

confidence: 99%

Effects of LncRNA GAS5/miR-137 general anesthesia on cognitive function by TCF4 inflammatory bodies in patients undergoing lumbar spinal canal decompression

Zhang

Chen

et al. 2022

Medicine

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Lumbar spinal stenosis is a common orthopedic disease in clinical practice at present. Postoperative cognitive dysfunction (POCD) refers to the phenomenon of impaired memory. However, whether long noncoding RNA (LncRNA) GAS5 contributes to the mechanism of cognitive function in undergoing lumbar spinal canal decompression remains unknown. Thus, the present study investigated the precise details of LncRNA GAS5 involvement in Postoperative cognitive dysfunction of patients undergoing lumbar spinal canal decompression. Patients undergoing lumbar spinal canal decompression with cognitive function and Normal healthy volunteers were obtained. C57BL/6 mice were maintained with a 2% concentration of sevoflurane in 100% oxygen at a flow rate of 2 L minute-1 for 4 hours. LncRNA GAS5 gene expression were up-regulated in patients undergoing lumbar spinal canal decompression. In mice model, LncRNA GAS5 gene expression also increased. LncRNA GAS5 promoted neuroinflammation in vitro model. LncRNA GAS5 raised cognitive impairment and increased neuroinflammation in mice model. LncRNA GAS5 suppressed miR-137 in vitro model. MiR-137 reduced neuroinflammation in vitro model. MiR-137 suppressed TCF4 protein expression in vitro model. Transcription factor TCF4 activates the expression of bHLH. Taking together, this experiment provide the first experimental and clinical evidence that LncRNA GAS5/miR-137 promoted anesthesia-induced cognitive function to increase inflammatory bodies in patients undergoing lumbar spinal canal decompression, suggesting it may be a biomarker of POCD and a potential therapeutic target for POCD.

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“…In general, the measurements may be performed with a “paper and pencil” test battery or with a computerized or digital test battery. Although those studies 11 , 12 are somewhat preliminary, we may notice that the completion of this digital test seems to be faster and easier to understand than conventional tests on paper, features that are quite attractive especially in elderly patients and in the early postoperative period.…”

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confidence: 97%

“…In this issue of the Brazilian Journal of Anesthesiology, two interesting studies provide new insights into the potential benefits of digital games in the area of cognitive evaluation and training before and after non-cardiac surgery. 11 , 12 Authors in both studies applied the MentalPlus® test, which is a digital game developed to assess and stimulate some key neuropsychological functions. The test takes approximately 25 minutes to be completed, addressing short- and long-term memory, selective and alternating attention, inhibitory control, and visual perception.…”

mentioning

confidence: 99%

“…In a second study, Lucatelli and colleagues 12 used the digital game MentalPlus® as a neuropsychological test to assess POCD in non-cardiac surgery patients. By using a robust statistical analysis with a generalized linear mixed model, authors have evaluated 60 patients and detected a significant reduction in the test performance after surgery in all phases of the digital test, except for the visual perception domain.…”

mentioning

confidence: 99%

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Perioperative cognitive evaluation and training: the use of digital games for assessment and prevention of cognitive decline after major non-cardiac surgery

Schmidt¹,

Carmona

2022

Brazilian Journal of Anesthesiology (English Edition)

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Assessment of a digital game as a neuropsychological test for postoperative cognitive dysfunction

Cited by 6 publications

References 33 publications

Comparing analog and digital neurocognitive tests with older adults: a study of the ISPOCD battery vs. a digital test battery from Mindmore

Comparing analog and digital neurocognitive tests with older adults: a study of the ISPOCD battery vs. a digital test battery from Mindmore

Effects of LncRNA GAS5/miR-137 general anesthesia on cognitive function by TCF4 inflammatory bodies in patients undergoing lumbar spinal canal decompression

Perioperative cognitive evaluation and training: the use of digital games for assessment and prevention of cognitive decline after major non-cardiac surgery

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