Assessment of 5-year overall survival in bladder cancer patients with incidental prostate cancer identified at radical cystoprostatectomy

Wu, Shulin; Lin, Sharron X.; Lu, Min; Subtelny, Alexander O.; Wang, Zongwei; Dahl, Douglas M.; Olumi, Aria F.; Wu, Chin‐Lee

doi:10.1007/s11255-019-02181-7

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…Thus, in the Chinese population, prostate cancer has become a serious health concern ( 4 , 5 ). According to the Global Cancer Data Center study, the five-year survival rate of patients with early-stage prostate cancer is 100%, whereas, the five-year survival rate of patients with late-stage prostate cancer is only 28% ( 6 ). As the disease progresses, patients often develop lower urinary tract symptoms (LUTS), including straining to urinate, dribbling, frequency, urgency, difficulty urinating, increased nocturia, hematuria, etc.…”

Section: Introductionmentioning

confidence: 99%

Analysis of factors associated with positive surgical margins and the five-year survival rate after prostate cancer resection and predictive modeling

Li,

Zhang,

Tian

et al. 2024

Front. Oncol.

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BackgroundThis study analyzed the risk factors associated with positive surgical margins (PSM) and five-year survival after prostate cancer resection to construct a positive margin prediction model.MethodsWe retrospectively analyzed the clinical data of 148 patients treated with prostatectomy. The patients were divided into PSM group and Negative surgical margins (NSM) group. Several parameters were compared between the groups. All patients were followed up for 60 months. The risk factors for PSM and five-year survival were evaluated by univariate analysis, followed by multifactorial dichotomous logistic regression analysis. Finally, ROC curves were plotted for the risk factors to establish a predictive model for PSM after prostate cancer resection.Results(1) Serum PSA, percentage of positive puncture stitches, clinical stage, surgical approach, Gleason score on puncture biopsy, and perineural invasion were significantly associated with the risk of PSM (P < 0.05). Serum PSA, perineural invasion, Gleason score on puncture biopsy, and percentage of positive puncture stitches were independent risk factors for PSM. (2) Total prostate-specific antigen (tPSA) by puncture, nutritional status, lymph node metastasis, bone metastasis, and seminal vesicle invasion may be risk factors for five-year survival. Lymph node metastasis and nutritional status were the main risk factors for the five-year survival of patients with prostate cancer. (3) After plotting the ROC curve, the area under the curve (AUC) [AUC: 0.776, 95%, confidence interval (CI): 0.725 to 0.854] was found to be a valid predictor of PSM; the AUC [AUC: 0.664, 95%, confidence interval (CI): 0.576 to 0.753] was also a valid predictor of five-year survival (P < 0.05). (4) The scoring system had a standard error of 0.02 and a cut-off value of 6. It predicted PSM after prostate cancer resection with moderate efficacy.ConclusionsSerum PSA, perineural invasion, puncture biopsy Gleason score, and percentage of positive puncture stitches were independent risk factors for positive surgical margins (PSM). Also, lymph node metastasis and nutritional status were the main risk factors for the five-year survival of patients with prostate cancer. Overall, the prediction efficacy of this scoring system concerning the risk of PSM after prostate cancer resection was moderate.

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Section: Introductionmentioning

confidence: 99%

Analysis of factors associated with positive surgical margins and the five-year survival rate after prostate cancer resection and predictive modeling

Li,

Zhang,

Tian

et al. 2024

Front. Oncol.

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“…Radikal sistoprostatektomi (RSP) mesane, prostat, seminal veziküller ve bölgesel lenf nodlarının rezeksiyonunu içeren, kasa invazyon gösteren ya da noninvaziv özellikte, yüksek riskli, tekrarlayan mesane kanserleri için standart tedavidir 1,2 . Ameliyat sonrası yaşam kalitesinin geliştirilebilmesi amacıyla apeks koruyucu ya da prostat koruyucu sistektomi teknikleri de geliştirilmiştir.…”

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“…Prostat-spesifik antijen (PSA) taramasıyla saptanıp radikal prostatektomi ile tedavi edilen PK'ler kadar agresif klinikopatolojik özelliklere sahip değildir. Bu nedenle iPK'ler klinik olarak önemli ve önemsiz olarak iki kategoride değerlendirilmekle birlikte büyük çoğunluğu klinik olarak önemsiz grupta yer almaktadır 1,5,11 . PK'nin düşük morbidite ve mortalite oranlarına sahip, yavaş büyüyen bir kanser olma eğiliminde olduğu göz önüne alındığında, insidental tümöre sahip hastalarda ek tedavi ve takip önemleri gerekliliği şüphelidir.…”

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Radikal Sistoprostatektomi Materyalinde İnsidental Prostat Kanseri Saptanan Olguların Klinikopatolojik Özellikleri

Vuruşkan

Yirmibeş

Vuruşkan

et al. 2021

Uludağ Üniversitesi Tıp Fakültesi Dergisi

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Mesane kanseri tedavisinde yaygın olarak uygulanan radikal sistoprostatektomi materyallerinde klinik bulgu vermeyen, insidental prostat kanserlerine sıklıkla rastlanmaktadır. Çalışmamızda, merkezimizde radikal sistoprostatektomi uygulanan hastalarda prostat kanseri insidansını, evresini, histopatolojik özellikleri ve bu tümörlerin prognoza etkisini değerlendirmeyi amaçladık. 2006 - 2020 arasında merkezimizde mesane kanseri nedeniyle radikal sistoprostatektomi uygulanan 499 hastaya ait dosyalar retrospektif olarak incelendi. İnsidental prostat tümörü 141 (%28,3) olguda tespit edildi. Tümörlerin tamamı prostat asiner adenokarsinomu olarak tanı aldı. 127 (%90,1) hasta pT2, 10 (%7,1) hasta pT3a ve 4 (%2,8) hasta pT3b tümöre sahipti. 35 (%24,8) hastada klinik olarak önemli prostat kanseri mevcuttu. Ameliyat öncesi artmış PSA değerine sahip 14 hastadan 4’ü klinik olarak anlamlı prostat tümörüne sahipti. Radikal sistoprostatektomi materyallerinde insidental prostat tümörü saptanma oranları yüksektir ancak tümörlerin çoğu klinik olarak önemsiz grupta yer alır. Serum PSA değerinin ameliyat öncesi insidental tümörü tespitinde faydası sınırlıdır. İnsidental prostat tümörüne sahip hastalarda olumsuz klinik seyir izlenmemekle birlikte prognozun asıl belirleyicisi mesane tümörüdür.

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“…Thus, in the Chinese population, prostate cancer has become a serious health concern (4,5). According to the Global Cancer Data Center study, the five-year survival rate of patients with early-stage prostate cancer is 100%, whereas, the five-year survival rate of patients with late-stage prostate cancer is only 28% (6). As the disease progresses, patients often develop lower urinary tract symptoms (LUTS), including straining to urinate, dribbling, frequency, urgency, difficulty urinating, increased nocturia, hematuria, etc.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of 5-year overall survival in bladder cancer patients with incidental prostate cancer identified at radical cystoprostatectomy

Cited by 6 publications

References 33 publications

Analysis of factors associated with positive surgical margins and the five-year survival rate after prostate cancer resection and predictive modeling

Analysis of factors associated with positive surgical margins and the five-year survival rate after prostate cancer resection and predictive modeling

Radikal Sistoprostatektomi Materyalinde İnsidental Prostat Kanseri Saptanan Olguların Klinikopatolojik Özellikleri

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