Assessment of 10-Year Major Osteoporotic and Femur Fracture Risk of Postmenopausal Women Using FRAX®

Demir, Ayşe Nur; Kutlu, Ruhuşen; Çivi, Selma

doi:10.5152/tftrd.2014.78736

Cited by 5 publications

(6 citation statements)

References 18 publications

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“…Despite the high rates of low bone mass in both sites, FRAX MOF and FRAX HF were classified as low risk and were statistically higher in the WLH, similar to a Turkish study in which FRAX MOF and FRAX HF were low in WLH with the same prevalence of low bone mass. 38 Sharma et al 18 found differences in BMD between WLH and HIV-negative controls in the LS; however, similar to our results, the prevalence of osteoporosis did not differ between the groups. Another similarity with study by Sharma et al 18 was that their participants were overweight just like ours.…”

Section: Discussionsupporting

confidence: 88%

Bone mass, fracture risk, and associated factors in postmenopausal women living with HIV

Leite-Silva,

Pinheiro,

Barbosa-Ferreira

et al. 2023

Menopause

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Objective The aim of this study was to assess the prevalence of low bone mass (osteopenia/osteoporosis), the factors associated with low bone mass, and the risk of fractures in Brazilian postmenopausal women living with HIV (WLH) in the Amazon region Methods This is a cohort study with a cross-sectional assessment at baseline conducted between March 2021 to August 2022 with 100 postmenopausal WLH undergoing antiretroviral therapy (ART) between 45 and 60 years of age and 100 age-matched HIV-negative women. Data on bone mineral density in the lumbar spine (LS) and femoral neck (FN) were collected using dual x-ray absorptiometry and the 10-year risk of hip and major osteoporotic fractures was assessed using the Fracture Risk Assessment tool (FRAX). Results The age of menopause onset occurred earlier in WLH (P < 0.001). No differences in prevalence of osteoporosis and osteopenia in LS and FN were observed except for a lower T score in FN in WLH (P = 0.039). The FRAX for major osteoporotic fracture and hip fracture were low in both groups, despite the mean of both FRAX scores was higher in WLH (P < 0.001). Multivariate analysis showed that years since menopause onset, higher body mass index and higher FRAX major osteoporotic fracture were associated with the WLH group, while a higher frequency of physical activity was registered in the HIV-negative group. Multivariate analysis also showed that in WLH, a lower T score in FN was associated with years since menopause onset and body mass index and that the number of years since menopause onset was associated with a lower T score in the LS and a higher score in the FRAX hip fracture. Conclusions Our findings show a high prevalence of low bone mass (osteopenia/osteoporosis) in Brazilian postmenopausal women from the Amazon region. Women living with HIV have higher FRAX scores than HIV-negative women and a lower T score in the FN.

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Section: Discussionsupporting

confidence: 88%

Bone mass, fracture risk, and associated factors in postmenopausal women living with HIV

Leite-Silva,

Pinheiro,

Barbosa-Ferreira

et al. 2023

Menopause

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“…In the current study, according to the NOF threshold criteria (≥20%), this group constituted 5% MO fracture risk and 4.4% hip fracture risk with FRAX with BMD [25]. Demir et al [19] found high risk to be <1% with and without BMD measurements for both fracture risks. That some significant fracture risk factors are not included (falls, bone turnover, style of dressing, lifestyle), that BMD is limited to the femoral neck, that the fracture risk may be over or underestimated, and that it is not used in patients who have been treated, are some of the disadvantages of the FRAX model [26][27][28].…”

Section: Discussionmentioning

confidence: 49%

“…As expected, the probability was higher in females than males. One of the risk factors of OP is body structure [19]. A significant relationship was found between BMI and OP in a study by Pinar et al [20] of females aged >45 years.…”

Section: Discussionmentioning

confidence: 99%

An evaluation of the 10-year major osteoporotic and hip facture risk using the FRAX score in Erzurum

İmerci¹

2018

Ann Clin Anal Med

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Aim: The aim of this prospective study was to provide an estimation of the 10-year probability of the four major osteoporotic fractures using fracture risk evaluation scale (FRAX) and to review the risk factors for osteoporosis in males and females aged over 50 years in Erzurum, Turkey. Material and Method: An evaluation was made 1254 patients who presented at the Outpatient Clinics of State Hospital in 2013. Taking the risk factors and bone mineral density (BMD) values into consideration, and using the FRAX risk evaluation scale, the 10-year major osteoporotic (MO) and hip fracture risks were evaluated for all the participants. Results: While a significant difference was seen between the genders in respect of measurements of the osteoporosis (OP) major risk fracture with BMD determined as mean 7.4% in females and 5.77% in males, and without BMD, as 8.27% in females and 4.59% in males and without BMD, the hip fracture risk was 2.92% in females and 1.91% in males (p=0.016, p<0.001, p<0.001, respectively), no significant difference was determined in the hip fracture risk with BMD at 2.62% in females and 3.05% in males (p=0.517). With an increase in body mass index (BMI), there was a decrease in the OP risk (p<0.001). With BMD, the MO fracture risk groups were formed of 84.5% low risk, 10.5% moderate risk and 5% high risk. Discussion: If BMD values were taken as the basis for medical treatment in Turkey, the use of scanning tests and fracture risk evaluation scales such as FRAX would be useful. However, to be able to better determine the extent of OP and the fracture risk in the general population and maybe to be able to determine threshold values which may be different in our population, there is a need for further multi-center studies including greater numbers of patients. Early diagnosis of OP, identification of risk groups for early treatment and prevention, and determination of the risk before a fracture all play an important role in the prevention of morbidity and mortality associated with OP and in the reduction of healthcare costs. Therefore, the aim of this study was to determine cases of osteopenia and OP in the early stages by measuring BMD and to determine the 10-year fracture risk using the FRAX scale in patients presenting at our hospital. Keywords Material and MethodIn the study period of 2013, a total of 1254 patients aged over 50 years, with no previous OP treatment underwent a DEXA scan at State Hospital. BMD measurements were taken with a DEXA Hologic Q 2000 device of the posteroanterior lumbar spine (L1-L4) and hip (femoral neck). The machine calibrations, tests, controls, and phantom measurements were applied routinely by certified technicians. The participants removed outer clothing and were weighed and measured, then DEXA scanning was applied. The BMD values were evaluated with the T-scores defined according to the peak young adult bone density value. According to the WHO classification, patients with a T-score of ≤-2.5 were accepted as osteoporotic, those with scores of -1--2.5 as os...

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“…One of the osteoporosis risk factors is the body structure. [ 26 ] Pınar et al[ 27 ] found no significant correlation between BMI and osteoporosis in a study of females aged >45 years. Similarly, Kutlu et al[ 28 ] also reported no statistically significant relationship between osteoporosis and BMI.…”

Section: Discussionmentioning

confidence: 99%

Agreement between the Turkey Guidelines and the Fracture Risk Assessment Tool®-based Intervention Threshold

2018

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BackgroundThe aim of this study was to evaluate the agreement between the fracture-risk assessment tool (FRAX®)-based intervention strategy in Turkey and the recommendations published in the Healthcare Practices Statement (HPS).MethodsThis descriptive cross-sectional study included individuals aged 40 to 90 years who were previously diagnosed as having osteoporosis but had not received any treatment. The intervention thresholds recommended by the National Osteoporosis Foundation for treatment were used. The criteria necessary for the start of administration of pharmacological agents in osteoporosis treatment were evaluated on the basis of the HPS guidelines.ResultsOf the 1,255 patients evaluated, 161 (12.8%) were male and 1,094 (87.2%) were female. In the evaluation, according to HPS, treatment was recommended for 783 patients (62.4%; HPS+) and not recommended for 472 (37.6%; HPS−). Of the 783 HPS+ patients, 391 (49.9%) were FRAX+, and of the 472 HPS− patients, 449 (95.1%) were FRAX−. A statistically significant difference was observed between the treatment recommendations of HPS and FRAX® (P<0.001). In the age group of 75 to 90 years, excellent agreement was found between the two strategies (Gwet's agreement coefficient 1=0.94). As age increased, the agreement between the two treatment strategies also increased.ConclusionsThe FRAX® model has different treatment recommendation rates from the HPS. The agreement between the two is at a minimal level. However, as age increased, so did the agreement between the FRAX® and the HPS treatment recommendations. In the recommendation to start pharmacological treatment primarily based on age, non-medical interventions that preserve bone density should be evaluated.

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Assessment of 10-Year Major Osteoporotic and Femur Fracture Risk of Postmenopausal Women Using FRAX®

Cited by 5 publications

References 18 publications

Bone mass, fracture risk, and associated factors in postmenopausal women living with HIV

Bone mass, fracture risk, and associated factors in postmenopausal women living with HIV

An evaluation of the 10-year major osteoporotic and hip facture risk using the FRAX score in Erzurum

Agreement between the Turkey Guidelines and the Fracture Risk Assessment Tool®-based Intervention Threshold

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