The evaluation of students' knowledge, skills and performance is one of inseparable parts in education process. Except of various teaching approaches, the history brought also various, more or less effective assessment methods. Nowadays, thanks to the learning management systems, the e-assessment methods become more available and widespread across education institutions. The heterogeneity in usage of various assessment methods at our faculty, as well as involvement of natural subjective factors, forced us to search for the solution that can be applicable and acceptable in all study programs, courses and examinations. Furthermore, the system should be secure, intuitive and available for all teachers and their students. In this paper, we describe main principles and methodology of e-Assessment management system we implemented into the medical education for automatic assessment of students' knowledge and competences at the