Assessment and Prognostic significance of renal dysfunction in acute stroke patients

Abstract

During hospitalization due to stroke, patients can have acute kidney injury (AKI) as a possible complication which is frequently overlooked and underestimated in clinical trials. Aims: To assess the prevalence of renal dysfunction in acute stroke patients and to assess its prognostic significance Design, Methods and Materials: A total of 100 patients were recruited for this study with diagnosis of stroke. Renal dysfunction was evaluated in the form of Acute kidney injury and unrecognized renal dysfunction (Baseline Normal serum Creatnine<1.2 mg/dl with EGFR< 60 ml/min on admission). The primary functional outcome was measured using the modified Rankin Scale at the time of discharge, 1 month after stroke onset. Statistical analysis: Analysis of data was done using SPSS-17.Independent t-test and chi-square test were used to calculate difference between two groups Results: Our study shows prevalence of acute kidney injury in patients of stroke is 15%. Moreover, the study showed that AKI after stroke was associated with higher in-hospital mortality and poorer functional outcome at 1 month. Conclusions: Acute kidney injury appears to be a common complication after stroke and is related to increased mortality and disability in stroke. Key Messages: AKI is common complication after stroke and frequent cause of poor functional outcome.