Assessment and nutrition education in patients with amyotrophic lateral sclerosis

Almeida, Claudinéa S.; Stanich, Patrícia; Salvioni, Cristina C. S.; Diccini, Solange

doi:10.1590/0004-282x20160145

Cited by 12 publications

(14 citation statements)

References 21 publications

(31 reference statements)

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“…Other studies also suggest beneficial effects (slower progression and/ or longer survival) of nutritional counseling [ 6 ], and of diets that contain omega-3 fatty acids [ 53 ], anti-oxidants and carotenes [ 78 , 121 ], acetyl carnitine [ 12 ], and Vitamin E [ 54 ] in ALS. The role of Vitamin D, however, remains unclear, with both its deficiency [ 20 , 82 ] and increased levels (-[ 15 ]) having been associated with worse prognosis in ALS.…”

Section: The Disease-modifying Effects Of Metabolic Disorders In Alsmentioning

confidence: 99%

Disease-modifying effects of metabolic perturbations in ALS/FTLD

Jawaid

Khan

Polymenidou

et al. 2018

Mol Neurodegeneration

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Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two fatal neurodegenerative disorders with considerable clinical, pathological and genetic overlap. Both disorders are characterized by the accumulation of pathological protein aggregates that contain a number of proteins, most notably TAR DNA binding protein 43 kDa (TDP-43). Surprisingly, recent clinical studies suggest that dyslipidemia, high body mass index, and type 2 diabetes mellitus are associated with better clinical outcomes in ALS. Moreover, ALS and FTLD patients have a significantly lower incidence of cardiovascular disease, supporting the idea that an unfavorable metabolic profile may be beneficial in ALS and FTLD. The two most widely studied ALS/FTLD models, super-oxide dismutase 1 (SOD1) and TAR DNA binding protein of 43 kDA (TDP-43), reveal metabolic dysfunction and a positive effect of metabolic strategies on disease onset and/or progression. In addition, molecular studies reveal a role for ALS/FTLD-associated proteins in the regulation of cellular and whole-body metabolism. Here, we systematically evaluate these observations and discuss how changes in cellular glucose/lipid metabolism may result in abnormal protein aggregations in ALS and FTLD, which may have important implications for new treatment strategies for ALS/FTLD and possibly other neurodegenerative conditions.

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Section: The Disease-modifying Effects Of Metabolic Disorders In Alsmentioning

confidence: 99%

Disease-modifying effects of metabolic perturbations in ALS/FTLD

Jawaid

Khan

Polymenidou

et al. 2018

Mol Neurodegeneration

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“…The global incidence proportion of ALS is 1.9 to 4.5/100,000 persons per year 1 . As age is an important predisposing factor, its prevalence increases to 6/100,000 people, among individuals between 58-60 years 29 .…”

Section: Introductionmentioning

confidence: 99%

Alterations in the stomatognathic system due to amyotrophic lateral sclerosis

et al. 2018

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Objectives:To compare the molar bite force, electromyographic activity, chewing efficiency and thickness of the masseter and temporalis muscles in individuals with amyotrophic lateral sclerosis (ALS) and healthy individuals.Material and Methods:Thirty individuals enrolled in the study were divided into the study group (with ALS, n=15) and control group (healthy individuals, n=15). Data regarding molar bite force (right and left), electromyographic activity (mandibular rest, right and left laterality, protrusion, and maximum voluntary contraction), chewing efficiency (habitual and non-habitual), and masticatory muscle thickness (rest and maximum voluntary contraction) were tabulated and subjected to statistical analysis (Student’s t-test, p≤0.05).Results:Comparisons between the groups demonstrated a statistically significant increase in the electromyographic activity of the right masseter (p=0.03) and left masseter (p=0.03) muscles during mandibular rest; left masseter (p=0.00), right temporalis (p=0.00), and left temporalis (p=0.03) muscles during protrusion; and right masseter (p=0.00), left masseter (p=0.00), and left temporalis (p=0.00) muscles during left laterality, in individuals with ALS as compared with healthy individuals. A statistically significant decrease was observed in the habitual chewing efficiency of the right masseter (p=0.00) and right temporalis (p=0.04) muscles in individuals with ALS. No statistically significant difference between the groups was found the masticatory muscle thickness and maximal molar bite force.Conclusions:ALS may lead to modifications in the activities of the stomatognathic system, including muscular hyperactivity and reduction in chewing efficiency; however, no change has been observed in the masticatory muscle thickness and molar bite force.

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“…After removal of duplicates, a total of 4326 records were screened, of which 150 full-text articles were considered potentially eligible for inclusion. Following detailed screening 14 articles [18][19][20][21][22][23][24][25][26][27][28][29][30][31] were included in the systematic review. The majority of the excluded articles did not relate to oral nutrition or the study design did not include a control group.…”

Section: Resultsmentioning

confidence: 99%

Interventions to promote oral nutritional behaviours in people living with neurodegenerative disorders of the motor system: A systematic review

et al. 2020

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Background & Aims Weight loss is common in people with neurodegenerative diseases of the motor system (NDMS), such as Parkinson's disease and Amyotrophic Lateral Sclerosis, and is associated with reduced quality of life, functional ability and survival. This systematic review aims to identify interventions and intervention components (i.e. behaviour change techniques [BCTs] and modes of delivery [MoDs]) that are associated with increased effectiveness in promoting oral nutritional behaviours that help people with NDMS to achieve a high-calorie diet. Methods 'human', 'face-to-face' and 'somatic therapy'. However, the robustness of these findings are low due to small number of studies, small sample sizes and large between-study variability. Conclusions Despite the limited evidence, these findings may help inform the development of more effective interventions to promote oral nutritional behaviours in people with NDMS. However, further research is needed to demonstrate which interventions, or intervention components, yield most benefit.

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Assessment and nutrition education in patients with amyotrophic lateral sclerosis

Cited by 12 publications

References 21 publications

Disease-modifying effects of metabolic perturbations in ALS/FTLD

Disease-modifying effects of metabolic perturbations in ALS/FTLD

Alterations in the stomatognathic system due to amyotrophic lateral sclerosis

Interventions to promote oral nutritional behaviours in people living with neurodegenerative disorders of the motor system: A systematic review

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