Assessment and Management of the Left Atrial Appendage Thrombus in Patients With Nonvalvular Atrial Fibrillation

Zhan, Yang; Joza, Jacqueline; Rawahi, Mohamed Al; Barbosa, Rodrigo S.; Samuel, Michelle; Bernier, Martin; Huynh, Thao; Thanassoulis, George; Essebag, Vidal

doi:10.1016/j.cjca.2017.12.008

Cited by 81 publications

(82 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Complete LA thrombus resolution is mandatory prior to performing procedures within the LA, such as catheter ablation for AF and LA appendage occlusion . Reasonable confidence in LA thrombus resolution rates would provide guidance as to the optimal time to reschedule procedures.…”

Section: Discussionmentioning

confidence: 99%

“…Complete LA thrombus resolution is mandatory prior to performing procedures within the LA, such as catheter ablation for AF and LA appendage occlusion. 7 Reasonable confidence in LA thrombus resolution rates would provide guidance as to the optimal time to reschedule procedures. For patients with concurrently diagnosed new rapid AF or flutter and new reduced left ventricular ejection fraction, expedited antiarrhythmic administration with or without subsequent transthoracic cardioversion may be desirable given additional co-morbidities associated with decompensated heart failure.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Non‐vitamin K oral anticoagulants versus warfarin for left atrial appendage thrombus resolution in nonvalvular atrial fibrillation or flutter

Hussain

Katz

Genuardi

et al. 2019

Pacing Clinical Electrophis

View full text Add to dashboard Cite

Background Non‐vitamin K oral anticoagulants (NOACs) have emerged as alternatives to vitamin K antagonists in select situations. For left atrial (LA) appendage thrombus in nonvalvular atrial fibrillation (AF) or flutter, guidelines recommend oral anticoagulation (OAC) for at least 3 weeks prior to reassessment. Data comparing NOACs to warfarin in this scenario are scarce. Methods A retrospective study identified subjects with nonvalvular AF or flutter who were: a) noted to have LA thrombus detected on transesophageal echocardiography (TEE), b) previously not receiving long‐term OAC; and c) evaluated for resolution of LA thrombus by follow‐up TEE between 3 weeks to less than 1 year of the initial TEE. Results The study included 45 subjects with mean age 63.2 years, 69% male, 78% white race/ethnicity, 42% paroxysmal, and mean CHA2DS2‐VASc score 3.4 ± 1.7. All LA thrombi were confined to the appendage. OAC received included apixaban (3), dabigatran (13), rivaroxaban (6), and warfarin (23), The median follow‐up time to repeat TEE was 67 (interquartile range, 49‐96) days. LA appendage thrombus resolution rates were 76% for the entire cohort, 77% for NOACs, and 74% for warfarin. In univariable logistic regression analysis, LA appendage thrombus resolution was similar for NOACs when compared to warfarin (odds ratio, 1.20; 95% confidence interval, 0.31‐4.69; P = .79). Conclusions In patients nonvalvular AF or flutter who were OAC naïve at the time of diagnosis with LA appendage thrombus, complete resolution was similar between NOACs and warfarin.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Non‐vitamin K oral anticoagulants versus warfarin for left atrial appendage thrombus resolution in nonvalvular atrial fibrillation or flutter

Hussain

Katz

Genuardi

et al. 2019

Pacing Clinical Electrophis

View full text Add to dashboard Cite

show abstract

“…A potential limitation of this design, as discussed above, is the use of phenprocoumon as the VKA arm instead of warfarin. Nevertheless, such trials are pivotal to guide optimal delivery of evidence based medicine …”

Section: Discussionmentioning

confidence: 99%

Oral anticoagulation and left atrial thrombi resolution in nonrheumatic atrial fibrillation or flutter: A systematic review and meta‐analysis

Wang

Sather

Hussain

et al. 2018

Pacing Clinical Electrophis

View full text Add to dashboard Cite

show abstract

“…Y.Zhan et al в Канадском кардиологическом журнале опубликовали большую обзорную статью по проблеме тромбоза УЛП при ФП [45]. Авторами было проанализировано более 100 работ по данной теме.…”

Section: антикоагулянтная терапия и тромбоз ушка левого предсердияunclassified

Left atrial appendage thrombosis in atrial fibrillation - current status of the problem

Кривошеев¹,

Башта

Красильникова

et al. 2020

Vestnik aritmologii

View full text Add to dashboard Cite

show abstract

Assessment and Management of the Left Atrial Appendage Thrombus in Patients With Nonvalvular Atrial Fibrillation

Cited by 81 publications

References 102 publications

Non‐vitamin K oral anticoagulants versus warfarin for left atrial appendage thrombus resolution in nonvalvular atrial fibrillation or flutter

Non‐vitamin K oral anticoagulants versus warfarin for left atrial appendage thrombus resolution in nonvalvular atrial fibrillation or flutter

Oral anticoagulation and left atrial thrombi resolution in nonrheumatic atrial fibrillation or flutter: A systematic review and meta‐analysis

Left atrial appendage thrombosis in atrial fibrillation - current status of the problem

Contact Info

Product

Resources

About