Assessment and management of the risk of SARS-CoV-2 infection in an IVF laboratory

Maggiulli, Roberta; Giancani, Adriano; Fabozzi, Gemma; Dovere, Lisa; Tacconi, Luisa; Amendola, Maria Giulia; Cimadomo, Danilo; Ubaldi, Filippo Maria; Rienzi, Laura

doi:10.1016/j.rbmo.2020.06.017

Cited by 37 publications

(39 citation statements)

References 37 publications

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“…Four main areas of potential 2-way infection have been identified, i.e., patient-staff, staff-staff, staff-cell, and cell-cell. The results of a failure modes and effect analysis conducted by a multidisciplinary IVF team showed that, except for cell-cell contamination, which is considered extremely unlikely, patient-employee, employee-employee, and employee-cell interaction periods are estimated to have a moderate to high infection risk [50]. Therefore, routine SARS-CoV-2 tests for patients and providers are necessary.…”

Section: Discussionmentioning

confidence: 99%

Challenges in Urology during the COVID-19 Pandemic

et al. 2020

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The COVID-19 pandemic has caused a global health threat. This disease has brought about huge changes in the priorities of medical and surgical procedures. This short review article summarizes several test methods for COVID-19 that are currently being used or under development. This paper also introduces the corresponding changes in the diagnosis and treatment of urological diseases during the COVID-19 pandemic. We further discuss the potential impacts of the pandemic on urology, including the outpatient setting, clinical work, teaching, and research.

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Section: Discussionmentioning

confidence: 99%

Challenges in Urology during the COVID-19 Pandemic

et al. 2020

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“…While the ART fraternity debates on resumption of services and struggles with strategies, one must keep in mind that ART pregnancies may not be absolutely protected from SARS-CoV-2 [39-41]. There is evidence of the presence of SARS-CoV-2 receptors in both female and male genital tract and gametes; the virus is detected in semen and may cause gonadal dysfunction [42-45].…”

Section: Discussionmentioning

confidence: 99%

Section: Ivf Treatment Detailsmentioning

confidence: 99%

Resuming assisted reproduction services during COVID-19 Pandemic: An Indian experience

Jirge¹,

Patwardhan²,

Paranjape³

et al. 2020

Preprint

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Purpose: The pandemic of COVID-19 has affected many countries and medical services including assisted reproductive treatment (ART) have been hampered. The purpose of the study was to assess the preparedness of ART clinics and staff to resume services and patients reasons to initiate treatment and key performance indicators (KPIs) of ART labs during pandemic. Methods: Semi-descriptive report of two private in-vitro fertilization (IVF) clinics in Maharashtra, India, when COVID-19 testing for asymptomatic people was unavailable. Time required for replenishing laboratory supplies, and staff preparedness to function under new norms of pandemic was documented. Infection mitigation measures at workplace and triaging strategy were evaluated. KPIs of the clinics were evaluated. Results: One-third of the patients consulted through telemedicine accepted or were eligible to initiate treatment upon clinic resumption. Lack of safe transport and financial constraints prevented majority from undergoing IVF, and only 9 percent delayed treatment due to fear of pandemic. With adequate training, staff compliance to meet new demands could be achieved within a week, but supply of consumables was a major constraint. 52 cycles of IVF were performed including fresh cycles and frozen embryo transfers with satisfactory KPIs even during pandemic. Conscious sedation and analgesia during oocyte retrieval was associated with reduced procedure time and no intervention for airway maintenance, compared to general anaesthesia. Self reported pain scores by patients ranged from nil to mild on a graphic rating scale. Conclusion: This study provides a practical insight and will aid in forming guidelines for resumption of IVF services during pandemic.

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“…[ 13 14 15 16 17 ] While the ART pregnancies are not absolutely protected from SARS-CoV-2, the possibility of vertical transmission from an IVF clinic may be negligible. [ 18 19 20 21 ] Presence of SARS-CoV-2 receptors in both female and male genital tract and gametes, and permissibility of trophectoderm and early placenta to the virus are of concern for ART fraternity. [ 22 23 24 25 26 27 28 29 30 ] The available evidence should be a part of pretreatment communication with couples planning ART.…”

Section: Introductionmentioning

confidence: 99%

Resuming Assisted Reproduction Services during COVID-19 Pandemic: An Initial Indian Experience

Jirge¹,

Patwardhan²,

Jirge³

et al. 2020

J Hum Reprod Sci

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Background: The pandemic of COVID-19 has affected many countries and medical services including assisted reproductive treatment (ART) have been hampered. Aim: The study was conducted to assess the preparedness of ART clinics and staff to resume services; patients' reasons to initiate treatment; and key performance indicators (KPIs) of ART laboratories during the pandemic. Setting and Design: This was a semidescriptive, prospective study in two private in vitro fertilization (IVF) clinics in Maharashtra, India, when COVID-19 testing for asymptomatic people was unavailable. Materials and Methods: Time required for replenishing consumables and clinic preparedness to function under “new norms” of pandemic was documented. Infection mitigation measures and triaging strategy were evaluated. KPIs following resumption were analyzed. The Student's t -test was performed for comparing parameters. Results: Thirty percent of the patients consulted through telemedicine accepted or were eligible to initiate treatment on clinic resumption. Lack of safe transport and financial constraints prevented majority from undergoing IVF, and 9% delayed treatment due to fear of pandemic. With adequate training, staff compliance to meet new demands was achieved within a week, but procuring consumables and injections was time-consuming. Fifty-two cycles of IVF were performed including fresh and frozen embryo transfers with satisfactory KPIs even during pandemic. Conscious sedation and analgesia during oocyte retrieval were associated with reduced procedure time and no intervention for airway maintenance compared to general anesthesia. Self-reported pain scores by patients ranged from nil to mild on a graphic rating scale. Conclusions: This study provides practical insight for the resumption of IVF services during the COVID-19 pandemic.

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Assessment and management of the risk of SARS-CoV-2 infection in an IVF laboratory

Abstract: This failure modes and effects analysis describes the precautionary administrative measures, the additional personal protective equipment required, and the modifications of IVF laboratory settings and procedures required to reduce the risk of aerosol-mediated viral infections.

Cited by 37 publications

References 37 publications

Challenges in Urology during the COVID-19 Pandemic

Challenges in Urology during the COVID-19 Pandemic

Resuming assisted reproduction services during COVID-19 Pandemic: An Indian experience

Resuming Assisted Reproduction Services during COVID-19 Pandemic: An Initial Indian Experience

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