Assessment and Management of Cancer- and Cancer Treatment–Related Cognitive Impairment

Allen, Deborah H.; Myers, Jamie; Jansen, Catherine E.; Merriman, John D.; Ah, Diane Von

doi:10.1016/j.nurpra.2017.11.026

Cited by 18 publications

(21 citation statements)

References 85 publications

(100 reference statements)

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“…CCT is aimed at improving, maintaining or restoring isolated cognitive functions (Nahum et al, 2013). Although CCT seems to be an acceptable and feasible intervention for improving cognitive and emotional outcomes (Allen et al, 2018), little evidence exists that CCT improves distal cognitive tasks or that it enhances everyday performance (Simons et al, 2016). Indeed, recent cognitive rehabilitation guidelines suggest integrating cognitive training together with individualised goal-directed interventions aimed at promoting occupational functioning (Cicerone et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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The feasibility of a combined model of online interventions for adults with cancer-related cognitive impairment

Maeir

Nahum

Makranz

et al. 2020

British Journal of Occupational Therapy

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Introduction The purpose of this study was to test the feasibility of a telehealth intervention combining computerised cognitive training and occupation-based treatment among adult cancer survivors experiencing cancer-related cognitive impairment. Method This was a single-arm study including six cancer survivors with cancer-related cognitive impairment. Participants completed the computerised retraining and functional treatment intervention consisting of 10 hours of computerised cognitive training (BrainHQ) and approximately 10 1:1 remote sessions with an occupational therapist using an occupation-based approach. Feasibility was measured in terms of recruitment, adherence, acceptability and potential effectiveness. Assessments were administered at baseline, post-intervention and at 3-month follow-up and included measures of occupational performance, objective cognitive functions, quality of life and mood questionnaires. Results From the nine participants enrolled in the study, six completed 8–13 weeks of computerised retraining and functional treatment intervention and reported high satisfaction levels. Positive and significant improvements were found in occupational performance, useful field of view and social quality of life (all P < 0.05). The positive gains were maintained at the 3-month follow-up. Conclusion A combined model of computerised cognitive training and occupation-based treatment delivered remotely to adults with cancer-related cognitive impairment was found feasible and may improve occupational performance, cognitive functions and quality of life.

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Section: Introductionmentioning

confidence: 99%

“…To date, computerised cognitive training (CCT) is a main treatment avenue being studied for CRCI that shows sufficient positive evidence to suggest clinical application (Allen et al., 2018). CCT is based on the assumption of neuroplasticity and involves repeatedly practising graded tasks adapted to the individual’s performance.…”

Section: Introductionmentioning

confidence: 99%

The feasibility of a combined model of online interventions for adults with cancer-related cognitive impairment

Maeir

Nahum

Makranz

et al. 2020

British Journal of Occupational Therapy

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“…Cognitive impairment can interfere with social activities, work and relationships with family members, as well as impede patient independence to perform routine tasks, 51 that is, eating, bathing, dressing, toileting, transferring and maintaining continence. Cognitive function can be evaluated with a range of methods, including self‐administered, validated questionnaires, HCP assessments and objective neuropsychological testing 52 . Initial pre‐treatment screening of cognitive function followed by periodic reassessment throughout the therapeutic process is recommended by the International Society of Geriatric Oncology 53 …”

Section: Role Of the Nurse Specialist In Managing Adverse Drug Eventsmentioning

confidence: 99%

“…As physical activity has been associated with improvements in perceived cognitive function, nurses should help patients access exercise programs and assist with referral to an exercise physiologist, if this is available 52 . Patients can also be encouraged to participate in cognitive behavioural group therapy or individualized cognitive training, for example, online home‐based programs, as these may also help to mitigate deterioration in cognitive function 51 .…”

Section: Role Of the Nurse Specialist In Managing Adverse Drug Eventsmentioning

confidence: 99%

New treatments for patients with non‐metastatic castration‐resistant prostate cancer: A nursing perspective

Olivier

Floyd

Smith

et al. 2021

Int J of Uro Nursing

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Globally, prostate cancer (PC) is a leading cause of death in men. Although androgen deprivation therapy (ADT) is the cornerstone of treatment for the disease, most patients eventually develop castration‐resistant PC (CRPC). Patients with non‐metastatic (nm) CRPC, the earliest clinical manifestation of castration resistance, are at risk of progressing to metastatic CRPC, which is associated with reduced life expectancy and poor quality of life. The nmCRPC treatment landscape has recently been transformed by the approval of three next‐generation oral androgen receptor (AR) inhibitors: apalutamide, enzalutamide and darolutamide. This review addresses available new treatment options for nmCRPC that target the AR, considering the effects of adverse event (AE) profiles and drug‐drug interactions (DDIs) when tailoring patient‐centric treatment to individual need, and discussing management strategies and nursing interventions for patients who experience drug‐related AEs. While no head‐to‐head comparisons of apalutamide, enzalutamide and darolutamide have been conducted to date, all three drugs have demonstrated comparable efficacy and maintained quality of life in phase III clinical trials, with differing AE profiles. The three treatments also demonstrate different potential for DDIs with other common medications that may be taken simultaneously. With the availability of new AR‐targeted options for nmCRPC, oncology nurses play a crucial role in the decision‐making process, educating and supporting patients on managing their PC, and ensuring that they receive the most appropriate treatment. As patients with nmCRPC are largely asymptomatic from their disease (with the exception of urinary/erectile symptoms), maintaining quality of life becomes a major objective when prescribing pharmacotherapy. Therefore, weighing treatment efficacy against the respective drug safety profile and examining the potential for adverse drug interactions with concomitant medications are important clinical considerations. Oncology nurses educate patients on potential treatment‐emergent AEs and their management and serve as advocates to ensure that patients receive optimal care based on their individual therapeutic requirements. They also provide information on available auxiliary services for patients and caregivers. This article provides an overview for the oncology nurse of the efficacy, safety, quality of life and DDI potential of these new AR‐targeted therapies in the nmCRPC setting, highlighting considerations for tailoring patient‐centric treatment to individual need. The importance of the oncology nurse in managing adverse drug reactions associated with ADT and AR inhibitors is highlighted and recommendations provided.

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“…Much attention has been focused on the use of non-pharmacological interventions for treating cognitive symptoms (Allen et al, 2018;Mayo et al, 2020), such as exercise (Campbell et al, 2020;Myers et al, 2019). With the recognized benefits of exercise on cancer-related symptoms and overall health, regular exercise is recommended for all cancer survivors (Campbell et al, 2019;National Comprehensive Cancer Network, 2014;Segal et al, 2017), although tailoring to an individual's ability and preferences is necessary.…”

Section: Introductionmentioning

confidence: 99%

The effect of mind-body exercise on cognitive function in cancer survivors: A systematic review

Farahani¹,

Soleimanpour²,

Mayo³

et al. 2022

CONJ

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Objective: Cancer-related cognitive impairments experienced by cancer survivors cause many to seek non-pharmacological intereventions to manage these symptoms. The aim of this systematic review was to evaluate the effects of one such intervention, mind-body exercise (MBE), on cognitive function in cancer survivors. Design: Searches for relevant studies were conducted in four electronic databases, including PubMed, Embase, Scopus, and Web of Science. The Joanna Briggs Institute and Jadad scales were utilized to evaluate the quality of the selected studies. Results: Eleven studies including 1,032 participants, published between 2006 and 2019, were selected for review based on specific inclusion criteria. Our results indicated that interventions including, yoga, tai chi, and qigong may improve objective and subjective cognitive function in cancer survivors. Conclusion: Cancer survivors experiencing cognitive symptoms may benefit from participation in MBE. Adequately powered randomized controlled trials are required to establish the short- and long-term effects of MBE on cognitive functioning.

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Assessment and Management of Cancer- and Cancer Treatment–Related Cognitive Impairment

Cited by 18 publications

References 85 publications

The feasibility of a combined model of online interventions for adults with cancer-related cognitive impairment

The feasibility of a combined model of online interventions for adults with cancer-related cognitive impairment

New treatments for patients with non‐metastatic castration‐resistant prostate cancer: A nursing perspective

The effect of mind-body exercise on cognitive function in cancer survivors: A systematic review

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