Assessment and clinicopathological correlation of p16 expression in head and neck squamous cell carcinoma

Ralli, Megha; Singh, Sunita; Yadav, S. P. S.; Sharma, Nisha; Verma, Renuka; Sen, Rajeev

doi:10.4103/0973-1482.151447

Cited by 22 publications

(33 citation statements)

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“…Different anatomic sites of HNSCC have different clinical behavior which suggests different intrinsic tumor factors and different p16 expression may be one of these factors [30], [31]. The tumor site was not associated with p16 expression in Smith et al [32] and Ralli et al [27] trials, and in our study (p 0.4, p 0.334, and p 0.840 respectively). Silva et al [33] in their report of a cohort of laryngeal and oropharyngeal HNSCC did not show statistical difference between p16 expression and tumor localization (p16 + in 58.3% and 52.4% respectively).…”

Section: Discussionsupporting

confidence: 49%

“…The carcinogenesis caused by tobacco and alcohol abuse and HPV infection is known to be synergistic to development of HNSCCs [34][35][36]. Our study could not find a statistical correlation between smoking tobacco and p16 status similar to findings by Lazarus et al [37] , and Ralli et al [27], but in contrast, Smith et al [32] showed significant association between alcohol and tobacco use (P < 0.05). Tumor grade is a powerful independent predictor of metastases in HNSCC.…”

Section: Discussioncontrasting

confidence: 45%

“…Our results were in agreement with that of [31], [39] who did not observe a significant correlation. In contrast Ralli et al [27] detected a significant association between lymph nodes involvement in 82.8% (53/64) and p 16 + staining (p 0.03). Lassen et al [28] studied impact of p 16 status on radiotherapy outcome in OPSCC and non-OPSCC (larynx and hypopharynx) groups of patients.…”

Section: Discussionmentioning

confidence: 70%

“…In agreement with Yuen et al [31] and Dragomir et al [38] there was no significant correlation between p16 expression and the histologic grade. However, Ralli et al [27] (p 0.045), Smith et al [32] (p 0.02), and Muirhead et al [39] (p 0.001) showed significant association between p16 status and tumor grade.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Meshman et al [23] studied 31 patients with SCC of the larynx (23) and hypopharynx (8), where 58% of patients were p16-negative; and 45.2% were p 16 positive. In a similar cohort with multiple sites HNSCC, positive p16 was observed in 59/75 (78.67%), while 11 (21.33%) cases were p16 negative [27]. Lassen et al [28] studied 1249 patients diagnosed with advanced SCC of the oropharynx (OPSCC), larynx and hypopharynx (non-OPSCC).…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

P16 Expression Independent of Human Papilloma Virus in Egyptian Patients with Head and Neck Squamous Cell Carcinoma: A Retrospective Study

2017

IJSR

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Section: Discussionsupporting

confidence: 49%

Section: Discussioncontrasting

confidence: 45%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

P16 Expression Independent of Human Papilloma Virus in Egyptian Patients with Head and Neck Squamous Cell Carcinoma: A Retrospective Study

2017

IJSR

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A systematic investigation of the association between HPV and the clinicopathological parameters and prognosis of oral and oropharyngeal squamous cell carcinomas

et al. 2017

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Human papillomavirus (HPV), the causal factor of cervical cancers, was closely linked to the etiology and prognosis of oropharyngeal squamous cell carcinoma (OPSCC), but its role in oral squamous cell carcinoma (OSCC) was unclear. In addition, few researches based on Chinese population were documented. Hence, we sought to investigate the relationship of HPV marker P16 protein to the clinicopathological parameters and survival of OPSCC and OSCC patients systematically to assess the influence of ethnic, regional difference on HPV susceptibility. Specimens from 93 OPSCC patients and 95 OSCC patients were recut, and P16 immunohistochemistry (IHC) was performed. Moreover, survival analysis was conducted to confirm the independent factors that influenced the prognosis. The P16 results were positive in 25.8% and 9.5% of patients with OPSCC and OSCC, respectively. The overall survival (OS) of HPV‐positive OPSCC patients was significantly longer than that of HPV‐negative OPSCC patients (P = 0.004). Conversely, statistical significance was not observed regarding the OS of OSCC patients (P = 0.343). Cox regression analysis indicated that T stage and P16 status were independent factors that affected the prognosis of OPSCC patients, and the smoking index influenced the prognosis of OSCC patients. Among OPSCC patients who received radiochemotherapy (RCT), HPV‐positive patients had a better survival rate than their HPV‐negative counterparts (P = 0.015). Conversely, no significant difference was observed between HPV‐positive and HPV‐negative OSCC patients who received RCT (P = 0.237). P16 is a credible surrogate by which to define HPV status. HPV expression had a favorable effect on OPSCC patients as opposed to their OSCC counterparts in this single center population‐based study.

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Evidence for different molecular parameters in head and neck squamous cell carcinoma of nonsmokers and nondrinkers: Systematic review and meta‐analysis on HPV, p16, and TP53

et al. 2020

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Background: The goal of this review was to present an overview of the currently identified molecular parameters in head and neck squamous cell carcinoma (HNSCC) of nonsmokers and nondrinkers (NSND). Methods: Following the PRISMA guidelines, a systematic search was performed using the electronic databases PubMed, Embase, and Google Scholar. Results: Of the 902 analyzed unique studies, 74 were included in a quantitative synthesis and 24 in a meta-analysis. Human papillomavirus (HPV) was reported as a molecular parameter in 38 studies, followed by p16 and TP53 (23 and 14 studies, respectively). The variety of other molecular parameters concerned sporadic findings in small numbers of NSND. Conclusions: HNSCC in NSND is more often related to HPV and p16 overexpression compared to tumors of smokers-drinkers. In a third of virusnegative tumors, TP53 mutations were detected with a mutational profile associated with aging and ultraviolet light exposure rather than to tobacco consumption. K E Y W O R D S head and neck cancer, human papillomavirus, nonsmokers, p16, TP53 1 | BACKGROUND Head and neck squamous cell carcinoma (HNSCC) usually results from excessive tobacco and alcohol consumption. 1 A third risk factor in head and neck carcinogenesis is high-risk human papillomavirus (HPV), especially in the oropharynx. 2,3 Patients with HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) usually have a Meetings at which the manuscript was presented: 7th World Congress of the

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Assessment and clinicopathological correlation of p16 expression in head and neck squamous cell carcinoma

Cited by 22 publications

References 1 publication

P16 Expression Independent of Human Papilloma Virus in Egyptian Patients with Head and Neck Squamous Cell Carcinoma: A Retrospective Study

P16 Expression Independent of Human Papilloma Virus in Egyptian Patients with Head and Neck Squamous Cell Carcinoma: A Retrospective Study

A systematic investigation of the association between HPV and the clinicopathological parameters and prognosis of oral and oropharyngeal squamous cell carcinomas

Evidence for different molecular parameters in head and neck squamous cell carcinoma of nonsmokers and nondrinkers: Systematic review and meta‐analysis on HPV, p16, and TP53

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