Assessing urinary levoglucosan and methoxyphenols as biomarkers for use in woodsmoke exposure studies

Hinwood, Andrea; Trout, M.; Murby, John; Barton, Caroline; Symons, Bob

doi:10.1016/j.scitotenv.2008.04.012

Cited by 24 publications

(19 citation statements)

References 27 publications

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“…Recently, the analysis of levoglucosan in air and urine has been used more frequently as a marker of exposure to woodsmoke [6,8]. To our knowledge, this is the first study following oral administration in humans.…”

Section: Discussionmentioning

confidence: 95%

“…We were able to show that the same is true for human metabolism. While Neitzel et al [8] reported an association between le voglucosan and CO exposure of firemen fighting wood fires, Hinwood et al [6] found no increase in levoglucosan con centration in firemen after a training fire. Both studies did not control for ambient exposure.…”

Section: Discussionmentioning

confidence: 98%

“…This situation could be improved by either intensifying ambient monitoring of markers or by applying specific markers of exposure in biomoni toring. Levoglucosan has also been proposed as a bio monitoring marker [6][7][8], but little has been known until now about its kinetics in humans. Animal stud ies indicate that most of the substance is excreted fast and unchanged [7], which would indicate low toxicity.…”

Section: Introductionmentioning

confidence: 99%

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Woodsmoke marker levoglucosan: Kinetics in a self-experiment

Moshammer

Weiß

Neuberger

2012

International Journal of Occupational Medicine and Environmental Health

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Objectives: Concerns on climate change are leading to the renaissance of wood burning and particulate exposures. Levo glucosan is used as a marker of woodsmoke in air and urine. Objectives: Contribution of data on urinary excretion of levo glucosan, to improve biomonitoring and source apportionment of woodsmoke. Materials and Methods: 1, 3, 5, and 7 hours after 5 mg of levoglucosan had been administered orally, urinary excretion was measured by HPLC and mass spectrometry. Results: After oral intake, urine concentrations increased rapidly, reached highest values after 3 hours, and after 7 hours approximately 70% of the administered dose was excreted. Conclusions: Urinary levoglucosan may be used for biomoni toring of woodsmoke exposure on the same day. Key words: Woodsmoke Biomonitoring, Levoglucosan, Human urine, ExcretionThe authors declare that the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (Ethics Com mittee, Medical University of Vienna) and with the Helsinki Declaration of 1975, as revised in 1983. The authors Hanns Moshammer (HM) and Manfred Neuberger (MN) experimented on themselves with a low dose, comparable to involuntary environmental exposure, and asked Stefan Weiss to analyze the excretion in their urine. HM and MN are independent and fully informed researchers.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Woodsmoke marker levoglucosan: Kinetics in a self-experiment

Moshammer

Weiß

Neuberger

2012

International Journal of Occupational Medicine and Environmental Health

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“…Unlike other sources, characterization of emission profiles may be insufficient because of the dynamic nature of the organic tracers. The use of biomarkers to assess wood smoke exposure is promising, yet there are apparent limitations as quantitative indicators of exposures (Dills et al, 2006;Clark et al, 2007;Hinwood et al, 2008;Migliaccio et al, 2009). Important future research questions identified by the risk assessment group for exposure assessment include: (1) What are the most prevalent exposure scenarios (i.e., source, concentration, duration) and pathways of exposure?…”

Section: Exposure Assessmentmentioning

confidence: 99%

Wood smoke risk assessment: Defining the questions

Morandi

Ward

2009

Inhalation Toxicology

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Risk assessment provides a framework for combining and evaluating scientific data on source-to-health effects for contaminants that could potentially affect the health of human populations. It utilizes an integrated approach to hazard identification, dose response, exposure assessment, and risk characterization. Since the range of potential exposure scenarios is considerable, given the complexity of wood-smoke sources and emissions, there is a need for defining the critical characteristics for the key parameters leading to adverse health outcomes. During the International Biomass Smoke and Health Effects (IBSHE) conference at the University of Montana (August 2007), the breakout group entitled "Risk Assessment: Defining the Questions" was tasked with evaluating the current state of the science in regard to risk assessment involving biomass smoke exposure. As a result of these discussions, important data gaps and future research questions were identified that are reported in this article.

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“…Since Levoglucosan is one of the most abundant particle-phase organic compounds in wood smoke (Table 3). Recently, several groups have begun to evaluate the suitability of urinary Levoglucosan as a biomarker for wood-smoke exposure (Migliaccio et al, 2009;Hinwood et al, 2008). In an inhalational exposure study Migliaccio found that mice exposed to wood smoke had higher levels of Levoglucosan in the urine, compared to control mice exposed to clean air.…”

mentioning

confidence: 99%