Assessing tumour haemodynamic heterogeneity and response to choline kinase inhibition using DCE-MRI in rodent models of glioblastoma

Abstract

This study was designed to monitor changes in DCE-MRI based parameters Ktrans, ve, τi and Fp in pre-clinical GBM models in response to choline kinase inhibition using a cluster analysis approach. The study demonstrates that region-based clustered pharmacokinetic parameters obtained using DCE-MRI can be used for detecting and assessing tumour heterogeneities which may be useful in assessing therapeutic response.