Assessing the toxicity in vitro of degradation products from deoxynivalenol photocatalytic degradation by using upconversion nanoparticles@TiO2 composite

Zhou, You; Wu, Shijia; Wang, Fang; Li, Qian; He, Chuxian; Duan, Nuo; Wang, Zhouping

doi:10.1016/j.chemosphere.2019.124648

Cited by 49 publications

(30 citation statements)

References 37 publications

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“…With the prepared dendritic‐like α‐Fe 2 O 3 under visible‐light irradiation (λ > 420 nm), 90.3% of DON could be degraded within 2 hr (Wang et al., 2019). In addition, TiO 2 and its composites have been employed as the catalyst for the photocatalytic degradation of mycotoxins (Douanla, 2019; Wu et al., 2019; Zhou et al., 2020). As reported by Sun et al., a kind of activated carbon supported TiO 2 catalyst (AC/TiO 2 ) was synthesized by a simple hydrothermal method for the photocatalytic degradation of AFB1.…”

Section: Applications Of Nanomaterials To Mycotoxin Controlmentioning

confidence: 99%

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Recent advances on emerging nanomaterials for controlling the mycotoxin contamination: From detection to elimination

Zhang

et al. 2020

Food Frontiers

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Mycotoxins, a toxic secondary metabolite, unpredictably, and unavoidably occur in foods and feeds, leading to adverse health impacts and enormous economic losses in the agriculture industry. Moreover, mycotoxin contamination has been a great threat for the public health and agriculture economy development worldwide. Therefore, the control of the mycotoxin contamination is of great importance and has caused rising concern worldwide. Recently, emerging nanomaterials have been promisingly applied in the control of mycotoxin contamination and have obtained many achievements. In this review, first of all, the type, occurrence, and toxicity of mycotoxins are simply discussed. Then, attentions are focused on the applications of emerging nanomaterials to controlling the mycotoxin contamination, including mycotoxin assay, the inhibition of mycotoxin production, the adsorption of mycotoxins, and mycotoxin elimination. In the end, the future opportunities and challenges on the toxicity, occurrence, and control of mycotoxins are tentatively put forward.

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Section: Applications Of Nanomaterials To Mycotoxin Controlmentioning

confidence: 99%

“…Copyright 2019, Elsevier. (d) Deoxynivalenol photocatalytic degradation by using upconversion nanoparticles@TiO 2 composite and assessment the toxicity in vitro of photocatalytic degradation products (Zhou et al, 2020). Copyright 2020, Elsevier agriculture industry.…”

Section: Conclusion and Prospectivementioning

confidence: 99%

Recent advances on emerging nanomaterials for controlling the mycotoxin contamination: From detection to elimination

Zhang

et al. 2020

Food Frontiers

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“…Cytochrome P450s (CYP450s) in the liver do not directly metabolise DON, but these enzymes may be closely involved in hepatotoxicity. Previous studies have found many mechanisms of liver injury caused by DON, such as lipid peroxidation, oxidative stress [15], apoptosis [1], in ammatory response [16] and autophagy [17], but this is all phenotypic. CYP450s may be important sources of toxic liver injury under DON exposure.…”

Section: Introductionmentioning

confidence: 97%

“…Deoxynivalenol (DON), as a serious natural source of global contaminant, is one of the most common mycotoxins produced by several pathogenic fungi, such as Fusarium graminearum [1]. DON is generally stable and therefore not easily destroyed or removed from food even after processing [2].…”

Section: Introductionmentioning

confidence: 99%

“…DON is mainly present in wheat, barley, oats, corn and other cereal crops [4], bread, biscuits, wheat snacks and other food products [5], animal milk, eggs [6] and fruit [7]. DON can also cause pollution in fresh and waste water treatment plants [1]. It was reported that DON was omnipresent in the primary e uent samples of three Swiss waste water treatment plants in concentrations of 32-118 ng/L [8].…”

Section: Introductionmentioning

confidence: 99%

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Dietary exposure of deoxynivalenol affected cytochrome P450 and growth related-gene expression via DNA methylation in piglet liver

Liu

Zhu

et al. 2020

Preprint

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Background Deoxynivalenol (DON) is an inevitable contaminant in animal feed and human food and can lead to decreased appetite and growth retardation in children and piglets, which are often used as models for children. Hepatotoxicity induced by DON is closely related to growth inhibition. Although many molecular mechanisms are related to the liver damage caused by DON, few studies have been done on cytochrome P450 (CYP450s) and DNA methylation, and the role of DNA methylation in growth inhibition of piglets was also unclear. Results In the present study, piglets were randomly assigned to the following three different dietary treatments for 4 weeks: control diet, diet containing 1 mg DON/kg feed, and diet containing 3 mg DON/kg feed. Compared to the control group, elevated alanine aminotransferase activity and globulin level were observed in DON groups; however, aspartate aminotransferase activity was decreased in 3 mg/kg DON group. DON exposure increased the mRNA expression of CYP450s including CYP1A1, CYP1A2, CYP2B22, CYP2C33, CYP2D25, CYP2E1, CYP3A22 and CYP3A39, in which DNA methylation was involved in the regulation of the expression of these enzymes. By estimating the benchmark dose value of the metabolic enzymes, CYP1A1 was found to be the most sensitive metabolic enzyme to evaluate the clinical liver injury caused by DON. DON upregulated the expression of DNA methyltransferases (DNMT1 and DNMT3B) in a dose-dependent manner, thus increasing the level of 5-mC in the whole genome. Notably, DON downregulated the expression of nicotinamide n-methyltransferase, possibly reducing the weight of the piglets. Additionally, 1 mg/kg DON decreased the expression of galanin-like peptide (GALP), while 3 mg/kg DON significantly increased the level of GALP through DNA methylation, thus affecting the appetite of the piglets. DON can significantly reduce the methylation level of insulin-like growth factor 1 (IGF-1) promoter and thus increase its expression. Conclusions Taken together, increased CYP450 expression and DNA methylation are important mechanisms of liver injury and growth inhibition induced by DON, which provide future reference values determination of antagonistic toxicity.

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Decontamination and Detoxification of Deoxynivalenol – An Emetic Toxin of Food and Feed

Sumalatha,

Maheshwar

2023

Anti‐Mycotoxin Strategies for Food and Feed

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Assessing the toxicity in vitro of degradation products from deoxynivalenol photocatalytic degradation by using upconversion nanoparticles@TiO2 composite

Cited by 49 publications

References 37 publications

Recent advances on emerging nanomaterials for controlling the mycotoxin contamination: From detection to elimination

Recent advances on emerging nanomaterials for controlling the mycotoxin contamination: From detection to elimination

Dietary exposure of deoxynivalenol affected cytochrome P450 and growth related-gene expression via DNA methylation in piglet liver

Decontamination and Detoxification of Deoxynivalenol – An Emetic Toxin of Food and Feed

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