Assessing the Safety of Post-exposure Rabies Immunization in Pregnancy

Sudarshan, Mysore Kalappa; Giri, Mimi; Mahendra, Bangalore Jayakrishnappa; Venkatesh, G.; Sanjay, Thitamaranahalli V.; Narayana, Doddabele Hanumanthaiah Ashwath; Ravish, H

doi:10.4161/hv.3.3.4010

Cited by 24 publications

(7 citation statements)

References 3 publications

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“…Both vaccine and equine rabies immunoglobulin were well tolerated with no reports of systemic or local AEs. The women had normal deliveries of healthy babies with no evidence of congenital abnormalities [70]. There is a clear consensus that pregnancy is not a contraindication to rabies PEP [71].…”

Section: Years Of Rabies Vaccination With Rabipurmentioning

confidence: 99%

30 years of rabies vaccination with Rabipur: a summary of clinical data and global experience

Giesen

Gniel

Malerczyk

2015

Expert Review of Vaccines

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Section: Years Of Rabies Vaccination With Rabipurmentioning

confidence: 99%

30 years of rabies vaccination with Rabipur: a summary of clinical data and global experience

Giesen

Gniel

Malerczyk

2015

Expert Review of Vaccines

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“…None of the women experienced any adverse side effects to the vaccine. [ 57 ] As cell culture vaccines are expensive and may not be economical for use in the developing countries, cost-effective intradermal regimens have been developed, which were approved by WHO in 1992. [ 58 ] Recently, the Government of India has also approved these regimens.…”

Section: Prevention Of Rabiesmentioning

confidence: 99%

Antemortem diagnosis and prevention of human rabies

Madhusudana

Sukumaran

2008

Ann Indian Acad Neurol

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Human rabies still continues to be a significant health problem in India and other developing countries where dogs are the major vectors of transmission. Rabies in humans can present in two clinical forms, i.e., furious and paralytic. While diagnosis of furious rabies can be made based on the typical symptoms and signs, paralytic rabies poses a diagnostic dilemma to the neurologists who may encounter these cases in their practice. Although there are certain clinical features that distinguish this disease from other forms of Guillain-Barre syndromes, confirmation of diagnosis may require laboratory assistance. Conventional techniques such as antigen detection, antibody assays and virus isolation have limited success. The recently introduced molecular techniques show more promise in confirming the cases of paralytic rabies. There has not been much success in the treatment of confirmed rabies cases and recovery from rabies is extremely rare. Therefore, preventive measures of this dreaded disease after an exposure become extremely important. The present article reviews the current status of human rabies with regard to antemortem diagnosis, disease management and post-exposure prophylaxis.

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“…Efforts have been made in India to effectively control rabies in dogs (Rahman, 2011). Presently almost 60% of rabies exposed people take one of the modern cell culture vaccines and nearly 5 million doses of these vaccines are sold every year (Sudarshan et al, 2005). The most cost effective strategy for preventing human rabies is the elimination of rabies in dogs through vaccination (WHO, 2001).…”

mentioning

confidence: 99%

A Cross Sectional Study to Understanding Demographics of Dog Bite Victims Attending Anti Rabies Ward in Chennai City, Tamil Nadu India

Bharathy¹,

Gunaseelan²

2017

Adv. Anim. Vet. Sci.

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| This cross sectional study was conducted by interviewing people attending the anti-rabies ward for post exposure rabies vaccination in a three Government General Hospitals, Chennai city. A total of 256 victims of dog bites from different areas of Chennai were interviewed with a pre tested structured questionnaire after informed verbal consent from victims between April 2013 and April 2014. Out of total 256 victims of dog bite, majority were males (71.87%) in the age group of 11 to 20 years (21.49%). Students outnumbered the general population (33.97%). Higher number of victims of dog bites was reported from Central Chennai. While 46 per cent of victims were bitten by stray dogs,in majority of victims, bite wounds were found in lower portion of the body (59.77%) with major exposure being minor scratches (57.4%). Fifty one per cent of bite victims washed their wounds and 48.44 per cent attended antirabies ward within 24 hours for post exposure prophylaxis. Our findings highlighted that a larger proportion of the bites were provoked, from owned pet dogs with exposures being very minor (scratch) in majority of cases which may not need post bite immunization. There is an urgent need to focus the educational campaigns throughout Chennai city with an effective dog population management combined with strategic immunization program and the effective use of rabies RIG and vaccination in dog bite cases as warranted could help to reduce rabies deaths.

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Assessing the Safety of Post-exposure Rabies Immunization in Pregnancy

Cited by 24 publications

References 3 publications

30 years of rabies vaccination with Rabipur: a summary of clinical data and global experience

30 years of rabies vaccination with Rabipur: a summary of clinical data and global experience

Antemortem diagnosis and prevention of human rabies

A Cross Sectional Study to Understanding Demographics of Dog Bite Victims Attending Anti Rabies Ward in Chennai City, Tamil Nadu India

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