Assessing the Safety of COVID-19 Vaccines: A Primer

Petousis‐Harris, Helen

doi:10.1007/s40264-020-01002-6

Cited by 43 publications

(39 citation statements)

References 29 publications

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“…A poll conducted in the USA in June 2020 showed only about 50% of Americans were committed to receiving a COVID-19 vaccine, with acceptance commitment among some communities being as low as 40% 29 . One possible explanation for our findings is that the vaccines against COVID-19 were developed at a record speed and in the context of an infodemic, both these factors can exacerbate heightened negative safety sentiments 30,31 . As the vaccination rollout continues globally, and with millions of doses administered in the first quarter of 2021, preliminary safety reports from the USA show COVID-19 vaccination results to mild adverse events and in rare cases, allergic reactions 32 .…”

Section: Discussionmentioning

confidence: 95%

Negative sentiment towards COVID-19 vaccines: A comparative study of USA and UK social media posts before vaccination rollout

2021

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Introduction: The global spread of the COVID-19 pandemic was rapid and devastating to humanity. The public health response to the pandemic was rapid too. Completion of COVID-19 vaccine development was achieved in under a year. The USA and the UK were the first countries to rollout COVID-19 vaccines to contain the pandemic. Successful rollout of the vaccines hinges on many factors, among which is public trust. Aim: To investigate the sentiments towards COVID-19 vaccines in the USA and UK prior to vaccination rollout. Methods: Neuro-linguistic programming with human validation was used to analyse a sample of 243,883 COVID-19 vaccine related social media posts from the USA and the UK in the period 28 July to 28 August 2020. The sentiment analysis measured polarity (positive, neutral, negative), and the themes present in negative comments. Results: In the sample of 243,883 social media posts, both the USA and the UK had a net sentiment profile of approximately 28% positive, 8% negative and 63% neutral sentiment. On further analysis, there were distinct differences between the two country’s social media sentiment towards COVID-19 vaccines. The differences were seen in the themes behind the negative sentiment. In the USA, the negative sentiments were mainly due to health and safety concerns, the fear of making a vaccine mandatory, and the role that pharmaceutical companies would play with the release of vaccines. In the UK the main driver of negative sentiment was the fear of making the vaccine mandatory (almost double the size of the sentiment in the USA). Conclusions: Negative sentiments towards COVID-19 vaccines were prevalent in the third quarter of 2020 in the USA and the UK. Reasons behind the negative sentiments can be used by authorities in the two countries to design evidence-based interventions to address the refusal of vaccination against COVID-19.

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Section: Discussionmentioning

confidence: 95%

Negative sentiment towards COVID-19 vaccines: A comparative study of USA and UK social media posts before vaccination rollout

2021

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“…This population is expected to find a high frequency of trust in COVID vaccines for two reasons: the first, emerging adults were included, and the second, being in higher education carriers. The findings are a strong wake-up call for educational and public health authorities to better understand student health education, particularly related to COVID-19, given the high safety and positive effects of the vaccination [29]. Health literacy is higher in the younger cohorts and people with more formal education years [13, 14, 30].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 vaccine distrust in Colombian university students: Frequency and associated variables

Campo‐Arias

Pedrozo-Pupo

2021

Preprint

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The study aimed to know the frequency and variables associated with COVID-19 vaccine distrust in students of a Colombian university. A cross-sectional study was carried out which participated emerging adult students of a Colombian university. A total of 1,136 students between 18 and 29 years (M= 22.0, SD = 3.0); most of them were female (66.0%), non-health students (82.8%), low-income (79.0%), and residents of urban areas (84.9%). It was frequent low institutional trust (74.8%), low cognitive, social capital (27.9%), low fear of COVID-19 (49.5%), low perceived stress related to COVID-19 (83.5%), and high COVID-19 vaccine distrust (78.9%). Non-health carrier (Adjusted OR = 3.63, 95%CI 2.58-5.10), rural residence (AOR = 1.85, 95%CI 1.13-3.04), low income (AOR = 1.84, 95%CI 1.31-2.57), and perceived stress related to COVID-19 (AOR = 1.74, 95%CI 1.20-2.54) were related to high COVID-19 vaccine distrust. In conclusion, COVID-19 vaccine distrust is high among emerging adult Colombian university students. The COVID-19 vaccine distrust is related to non-health science carriers, rural residents, low-income, and low-perceived stress related to COVID-19. The COVID-19 related health literacy should be improved in students of this university considering socio-cultural background.

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“…This may be attributable to the unprecedented time frame of vaccine development and approval. Vaccine development typically spans across 10–15 years from initial scientific discovery, preclinical and clinical studies, to licensure [ 5 ]. The sped-up timeline may be attributable to the rapid deployment of flexible vaccine platforms, generous funding, innovative trial designs and multinational cooperation.…”

Section: Introductionmentioning

confidence: 99%

Ophthalmological Considerations for COVID-19 Vaccination in Patients with Inflammatory Eye Diseases and Autoimmune Disorders

et al. 2021

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The global impact imposed by the coronavirus disease 2019 (COVID-19) pandemic may be soon alleviated by the introduction and worldwide dissemination of safe and effective vaccines. This expedited timetable for development and approval of COVID-19 vaccines is an unprecedented extraordinary, concerted achievement by the scientific community. With the pending global rollout of vaccines, each with different mechanisms of action, physicians of various specialties will need to identify vulnerable patient groups for special considerations or advice. In this commentary, we analyse the important considerations for COVID-19 vaccines in patients with inflammatory eye diseases. Scrutiny of immunogenicity and adverse effects, particularly antibody-dependent enhancement, would better help in counselling these patients undergoing vaccination. More research on pharmacovigilance would allow for tailored guidelines and personalised management strategies.

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Assessing the Safety of COVID-19 Vaccines: A Primer

Cited by 43 publications

References 29 publications

Negative sentiment towards COVID-19 vaccines: A comparative study of USA and UK social media posts before vaccination rollout

Negative sentiment towards COVID-19 vaccines: A comparative study of USA and UK social media posts before vaccination rollout

COVID-19 vaccine distrust in Colombian university students: Frequency and associated variables

Ophthalmological Considerations for COVID-19 Vaccination in Patients with Inflammatory Eye Diseases and Autoimmune Disorders

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