Assessing the Role of Melatonin in the Modulation of Visual Functions in the Mouse

Baba, Kenkichi; Tosini, Gianluca

doi:10.1007/978-1-0716-2593-4_38

Cited by 1 publication

(1 citation statement)

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“…The retina and the hypothalamic suprachiasmatic nucleus have also emerged as good models to functionally characterize melatonin and determine the structure activity relationship of melatonin and other indoles on the modulation of visual functions or of circadian rhythmicity, respectively [84,[94][95][96]. After the cloning of melatonin receptors, their heterologous expression helped to determine the function and pharmacological profile of each subtype with precision.…”

Section: Functional Characterization Of Melatonin Receptorsmentioning

confidence: 99%

Molecular Characterization and Pharmacology of Melatonin Receptors in Animals

2023

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Melatonin, the hormone of darkness, is secreted in minute amounts during the night and is virtually undetectable during the day. Melatonin mainly acts on high-affinity G protein-coupled receptors. The present review will trace the path of the discovery of melatonin receptors from their cloning, expression and purification to the development of recent radioactive and fluorescent tracers. We will then report on the state-of-the-art of melatonin receptor functional properties, including ligand bias and system bias due to receptor-associated proteins and receptor heteromers. Currently available antibodies raised against melatonin receptors will be critically reviewed here for the first time. The review will close with future perspectives in terms of the discovery of allosteric ligands and the in vivo validation of a range of melatonin receptor-associated signaling complexes to improve future drug development.

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Section: Functional Characterization Of Melatonin Receptorsmentioning

confidence: 99%