Assessing the role of landscape connectivity on Opisthorchis viverrini transmission dynamics

Wang, Yi-Chen; Yuen, Roy; Feng, Chen‐Chieh; Sithithaworn, Paiboon; Kim, Ick-Hoi

doi:10.1016/j.parint.2016.06.002

Cited by 13 publications

(9 citation statements)

References 48 publications

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“…Monitoring fecal indicator bacteria in and around snail habitat offers the potential to characterize snail infection risk based on fecal input into snail habitat. Recent studies have related fecal indicator bacteria concentrations in surface water in and around snail habitat to potential sources of fecal contamination, such as septic tanks [16, 17], and to temporal patterns of snail infections [15]. Testing water for fecal indicator bacteria is relatively inexpensive, does not require sophisticated laboratory equipment and requires far fewer samples than snail infection testing.…”

Section: Discussionmentioning

confidence: 99%

“…Kaewkes et al [15] found that concentrations of fecal indicator bacteria in water collected from snail habitat can be linked to temporal and spatial patterns of snail infections. Recent studies have used this approach to define pathways by which poor sanitation [16, 17], landscape characteristics [17] and snail habitat type [18] impact fecal contamination of Bithynia snail habitat. However, these recent studies have found few or no infected snails at their sampling sites [16–18], which makes it challenging to link these potential infection pathways to actual snail infections.…”

Section: Introductionmentioning

confidence: 99%

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Culture of fecal indicator bacteria from snail intestinal tubes as a tool for assessing the risk of Opisthorchis viverrini infection in Bithynia snail habitat

et al. 2019

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BackgroundLike many trematodes of human health significance, the carcinogenic liver fluke, Opisthorchis viverrini, is spread via fecal contamination of snail habitat. Methods for assessing snail exposure to fecal waste can improve our ability to identify snail infection hotspots and potential sources of snail infections. We evaluated the feasibility of culturing fecal indicator bacteria from Bithynia snail intestinal tubes as a method for assessing snail exposure to fecal waste. Snails and water samples were collected from a site with a historically high prevalence of O. viverrini infected snails (“hotspot” site) and a site with historically no infected snails (“non-hotspot” site) on two sampling days. Snails were tested for O. viverrini and a stratified random sample of snails from each site was selected for intestinal tube removal and culture of gut contents for the fecal indicator bacteria, Escherichia coli. Water samples were tested for E. coli and nearby households were surveyed to assess sources of fecal contamination.ResultsAt the hotspot site, 26 of 2833 Bithynia siamensis goniomphalos snails were infected with O. viverrini compared to 0 of 1421 snails at the non-hotspot site. A total of 186 snails were dissected and cultured. Escherichia coli were detected in the guts of 20% of uninfected snails, 4% of O. viverrini-positive snails and 8% of snails not examined for cercarial infection at the hotspot site. Only one of 75 snails from the non-hotspot site was positive for E. coli. Accounting for sampling weights, snails at the hotspot site were more likely to have gut E. coli than snails from the non-hotspot site. The concentration of fecal indicator bacteria in surface water was higher at the hotspot vs non-hotspot site on only the first sampling day.ConclusionsFecal indicator bacteria can be detected in the intestinal tubes of Bithynia snails. The presence of fecal indicator bacteria in Bithynia snail guts may indicate risk of O. viverrini infection in snail populations. This method has the potential to aid in identifying locations and time windows of peak snail infection risk and may be applicable to other trematodes of human-health significance.Electronic supplementary materialThe online version of this article (10.1186/s13071-019-3313-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Culture of fecal indicator bacteria from snail intestinal tubes as a tool for assessing the risk of Opisthorchis viverrini infection in Bithynia snail habitat

et al. 2019

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“…As such, Ov transmission needs to be understood in its social-ecological context, including not only natural wetland ecology, but also with an appreciation for the need to connect local landscape management strategies and cultural/agrarian practices/policies with regional and global economic decisions [20]. This is particularly important considering the current context of agriculture intensification, waterscape fragmentation [21] and livelihood shifts in northeastern Thailand where unregulated agrochemical use [22] and large-scale irrigation systems disturb local wetlands ecological dynamics, modify patterns of local communities’ environmental risk exposure, wealth, poverty and vulnerability while seemingly improving regional and national capital.…”

Section: Embracing Complexity For Liver Fluke Sustainable Controlmentioning

confidence: 99%

Prospects and Challenges towards Sustainable Liver Fluke Control

Sripa

Echaubard

2017

Trends in Parasitology

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The liver fluke Opisthorchis viverrini (Ov) is endemic in Southeast Asia where more than 10 million people are estimated to be infected. The infection is associated with several hepatobiliary diseases including cholangiocarcinoma (CCA). Northeast Thailand is a hotspot of Ov transmission and despite extensive public health prevention campaigns led by the government, Ov infection prevalence is still high. High infection rates result from cultural and ecological complexities where wet-rice agrarian habitats, centuries old raw food culture and the parasite complex biology combine to create an ideal transmission arena. Here we review the state of our knowledge regarding the social-ecological determinants underlying Ov transmission. We also describe an integrative research rationale for liver fluke control better aligned with sustainable health development.

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“…felineus, a close relative of the Asian liver fluke, Opisthorchis viverrini, has a complex life cycle that includes two freshwater intermediate hosts; namely, a mollusk of the genus Bithynia and the fish species of the family Cyprinidae, which act as first and second intermediate hosts, respectively [1,13]. Humans acquire an infection through the consumption of raw or insufficiently cooked cyprinoid fish [14][15][16]. A wide range of mammals such as cats, dogs, foxes, and bears, [1,13] are known reservoir hosts of O. felineus and are responsible for transmitting the fluke to Bithynia snails [14,17].…”

Section: Introductionmentioning

confidence: 99%

Opisthorchis felineus infection, risks, and morbidity in rural Western Siberia, Russian Federation

et al. 2020

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Background The liver fluke, Opisthorchis felineus, is widely distributed throughout Europe and large parts of the Russian Federation. In Western Siberia, information about opisthorchiasis is lacking although infection may lead to severe liver and bile duct diseases. We aimed to assess the current prevalence of O. felineus infection along with associated risk factors and morbidity in rural Western Siberia. Methods We conducted a community-based, cross-sectional study in the rural Shegarskiy district, Tomsk Oblast, Russian Federation. All household members (� 7 years) present on the survey day were enrolled (n = 600). Two stool samples per person were examined for helminth eggs, using PARASEP (DiaSys Ltd, UK). The number of eggs per gram (EPG) of feces was recorded. Each study participant was interviewed to determine risk factors, using a pretested questionnaire. An abdominal ultrasonography examination of liver and bile ducts was performed with a mobile, high resolution ultrasound device. In total, 488 persons completed assessments (two stool samples, completed questionnaires); of those, 436 individuals had an ultrasonography (US) examination. Results We observed a prevalence of O. felineus infection of 60.2%. Significant risk factors for infection were the consumption of river fish (odds ratio from adjusted analysis [aOR] 2.4, 95% CI

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Assessing the role of landscape connectivity on Opisthorchis viverrini transmission dynamics

Cited by 13 publications

References 48 publications

Culture of fecal indicator bacteria from snail intestinal tubes as a tool for assessing the risk of Opisthorchis viverrini infection in Bithynia snail habitat

Culture of fecal indicator bacteria from snail intestinal tubes as a tool for assessing the risk of Opisthorchis viverrini infection in Bithynia snail habitat

Prospects and Challenges towards Sustainable Liver Fluke Control

Opisthorchis felineus infection, risks, and morbidity in rural Western Siberia, Russian Federation

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