Assessing the Role of High-resolution Microultrasound Among Naïve Patients with Negative Multiparametric Magnetic Resonance Imaging and a Persistently High Suspicion of Prostate Cancer

Avolio, Pier Paolo; Lughezzani, Giovanni; Fasulo, Vittorio; Maffei, Davide; Sánchez-Salas, Rafael; Paciotti, Marco; Saitta, Cesare; Carne, Fabio De; Saita, Alberto; Hurle, Rodolfo; Lazzeri, Massimo; Guazzoni, Giorgio; Buffi, Nicolò Maria; Casale, Paolo

doi:10.1016/j.euros.2022.11.015

Cited by 8 publications

(3 citation statements)

References 30 publications

(40 reference statements)

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“…A recent study by Avolio et al found similar rates of clinically significant prostate cancer for patients with negative MRI undergoing microUS informed prostate biopsy at 27% (34/125) compared to 25% (14/56) 13 . Their results showed a lower rate of negative microUS in their study population when compared to this study at 22% (28/125) compared with this study showing 66% (37/56) having PRI-MUS ≤2.…”

Section: Cuaj -Original Researchmentioning

confidence: 91%

Micro-ultrasound for the detection of clinically significant prostate cancer in biopsy-naive men with negative MRI

Albers,

Bennett,

Evans

et al. 2024

CUAJ

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Introduction: Despite a negative magnetic resonance imaging (MRI), some patients may still harbor clinically significant prostate cancer (csPCa, Gleason grade group ≥2). High-resolution micro-ultrasound (microUS) is a novel imaging technology that could visualize csPCa that is missed by MRI. Methods: This retrospective review included 1011 consecutive patients biopsied between September 2021 and July 2023 in Alberta, Canada. Among them were 103 biopsy-naive patients with negative MRI (Prostate Imaging Reporting & Data System [PI-RADS] ≤2) undergoing microUS-informed prostate biopsy (n=56) scored using Prostate Risk Identification Using Micro-ultrasound (PRI-MUS) or standard transrectal ultrasound prostate biopsy (n=47). The primary outcome was detection rate of csPCa stratified by biopsy technique and PRI-MUS score. Results: MicroUS biopsy identified csPCa in 14/56 (25%) compared to standard biopsy in 8/47 (17%) (p=0.33). Patients with lesions PRI-MUS ≥3 had csPCa detected at a higher rate compared to patients with PRI-MUS ≤2 (42% vs. 16%, p=0.03). The csPCa detection rate was significantly different comparing patients with PSA density <0.15 and PRI-MUS ≤2 compared to patients with PSA density ≥0.15 and PRI-MUS ≥3 (14% vs. 60%, p=0.02). Conclusions: MicroUS may aid in the detection of csPCa for patients with negative MRI.

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Section: Cuaj -Original Researchmentioning

confidence: 91%

Micro-ultrasound for the detection of clinically significant prostate cancer in biopsy-naive men with negative MRI

Albers,

Bennett,

Evans

et al. 2024

CUAJ

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Section: Introductionmentioning

confidence: 99%

“…Recently, high-resolution transrectal ultrasonography (TRUS) has the potential to provide more detailed imaging features of prostate cancer [8][9][10]. Some imaging features are not visible on MRI, but are visible on TRUS alone [8][9][10]. TRUS cannot replace MRI completely in characterizing prostate cancer, but there is an increasing need for radiologists and urologists to use TRUS for cancer detection and biopsy.…”

Section: Introductionmentioning

confidence: 99%

Added values of transrectal ultrasonography to magnetic resonance imaging in characterizing prostate cancer: A narrative review

Park

2023

Precis Future Med

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Many radiologists and urologists believe that magnetic resonance imaging (MRI) is superior to transrectal ultrasonography (TRUS) in the detection and assessment of prostate cancer. Thus, they relied on MRI alone for tumor characterization. However, the role of TRUS in prostate cancer assessment remains unclear. This information on TRUS findings can aid radiologists and urologists in detecting, targeting, and staging cancers. Additionally, there are some imaging features that are unseen on MRI, but are visible on TRUS. However, few studies have addressed the added value of TRUS in the preoperative evaluation of prostate cancer. This review aimed to assess the added value of TRUS to preoperative MRI for prostate cancer detection, characterization, and staging.

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The diagnostic accuracy of micro-ultrasound for prostate cancer diagnosis: a review

et al. 2023

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Assessing the Role of High-resolution Microultrasound Among Naïve Patients with Negative Multiparametric Magnetic Resonance Imaging and a Persistently High Suspicion of Prostate Cancer

Cited by 8 publications

References 30 publications

Micro-ultrasound for the detection of clinically significant prostate cancer in biopsy-naive men with negative MRI

Micro-ultrasound for the detection of clinically significant prostate cancer in biopsy-naive men with negative MRI

Added values of transrectal ultrasonography to magnetic resonance imaging in characterizing prostate cancer: A narrative review

The diagnostic accuracy of micro-ultrasound for prostate cancer diagnosis: a review

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