Assessing the relationship between perfluoroalkyl substances, thyroid hormones and binding proteins in pregnant women; a longitudinal mixed effects approach

Berg, Vivian; Nøst, Therese Haugdahl; Hansen, Solrunn; Elverland, Astrid; Veyhe, Anna Sofía; Jorde, Rolf; Odland, Jon Øyvind; Sandanger, Torkjel M.

doi:10.1016/j.envint.2015.01.007

Cited by 79 publications

(70 citation statements)

References 34 publications

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“…of maternal blood collected in the second trimester of pregnancy and 3 days and 6 weeks after delivery. In women in the highest quartile of PFOS there was a positive association between the compounds and TSH levels, while women in the highest quartile of PFDA and PFUnDA had reduced levels of TT3 and FT3 [40]. A systematic review of the available epidemiological studies has been recently published: studies focusing on the relationship between TSH, T3, T4 and different PFAS (in particular perfluorohexane sulfonate -PFHxS-, perfluorooctanoic acid -PFOA-, perfluorooctane sulfonate -PFOS-or perfluorononanoic acid -PFNA-) in pregnant women or young children were selected.…”

Section: Pesticidesmentioning

confidence: 99%

Thyroid Disrupting Chemicals

Calsolaro

Pasqualetti

Niccolai

et al. 2017

Preprint

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Endocrine disruptor compounds are exogenous agents able to interfere with a gland function, exerting their action across different functional passages, from the synthesis to the metabolism and binding to receptors of the hormone produced. Several issues such as different levels and time of exposure and different action across different ages as well as gender, make the study of endocrine disruptors still a challenge. Thyroid is very sensitive to the action of disruptors, and considering the importance of a correct thyroid function for physical and cognitive functioning, addressing this topic should be considered a priority. In this review we examined the most recent studies, many of them concentrating on maternal and child exposure, conducted to assess the impact of industrial chemicals which showed an impact on thyroid function. So far, the number of studies conducted on that topic is not sufficient to provide solid conclusions and lead to homogeneous guidelines. The lack of uniformity is certainly due to differences in areas and populations examined, the different conditions of exposures and the remarkable inter-subject variability. Nonetheless, the European Commission for Health and Food Safety is implementing recommendations to ensure that substances identified as endocrine disruptors will be withdrawn from the market.

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Section: Pesticidesmentioning

confidence: 99%

Thyroid Disrupting Chemicals

Calsolaro

Pasqualetti

Niccolai

et al. 2017

Preprint

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“…PFASs and OCs can cross the placental barrier [6, 7], and in utero exposure have been associated with adverse effects of growth and development in both animal and epidemiological studies [8–10]. These environmental pollutants have been categorized as endocrine disruptive chemicals (EDCs) due to their disruption in the regulation of estrogen and thyroid hormones [11, 12]. In 2012, a report from the United Nations Environment Programme (UNEP) and the World Health Organization (WHO) identified EDCs as an emerging health challenge to vulnerable individuals in society, particularly fetuses and children [13].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Maternal Serum Levels of Perfluoroalkyl Substances and Organochlorines: A Descriptive Study of Parous Women in Norway and Sweden

et al. 2016

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IntroductionPerfluoroalkyl substances (PFASs) and organochlorines (OCs) are ubiquitous and persistent in the environment and proposed endocrine disrupting chemicals (EDCs). They can be transferred across the placenta during pregnancy, and studies suggest that the prenatal period may be particularly sensitive for influences on fetal growth and development. Several studies have investigated socio-demographic and pregnancy related factors associated with maternal serum PFAS and OC levels, but few studies have been conducted in time periods with increasing emissions of PFASs and recent emissions of OCs.MethodsSerum from 424 pregnant women participating in the NICHD Scandinavian Successive Small-for-gestational Age (SGA) births study was collected in 1986–1988, and analyses of two PFASs and six OCs were conducted. Associations between EDCs and geographic, time dependent, socio-demographic and pregnancy related variables were evaluated by using multivariable linear regression models.ResultsPrevious breastfeeding duration, time since last breastfeeding period, sampling date and country of residence were important factors associated with serum levels of PFOS and PFOA. Smoking status and pre-pregnancy BMI were negatively associated with PFOS, and maternal height was borderline negatively associated with PFOS and PFOA. Glomerular filtration rate (GFR) was negatively associated with PFOS in a sub-sample. Maternal serum levels of OCs were positively associated with maternal age, and negatively associated with previous breastfeeding duration and sampling date. Smoking had a consistently negative association with PCB 118 in a dose-dependent manner. Education level, pre-pregnancy BMI and alcohol consumption varied in importance according to the compound under study.ConclusionsSeveral maternal factors, including potentially modifiable factors, markers of pregnancy physiology and factors also related to perinatal outcomes were associated with EDC levels. Results from this study are relevant to populations with still high PFAS and OC levels, i.e. developing countries. Moreover, we can use this knowledge about associated factors on emerging EDCs with similar properties.

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“…The Northern Norway Mother-and-Child contaminant Cohort Study (MISA) investigated the potential association between thyroid hormones, thyroid binding protein, TPOAb and different PFASs (PFOS, perfluorodecanoate (PFDA) and perfluoroundecanoate (PFUnDA)) in three samples of maternal blood collected in the second trimester of pregnancy and 3 days and 6 weeks after delivery. In women in the highest quartile of PFOS (range 11.1-35.9 mg/mL) there was a positive association between the compounds and TSH levels, while women in the highest quartile of PFDA (range 0.31-2.34 ng/mL) and PFUnDA (range 0.4-0.96 ng/mL) had reduced levels of TT 3 and FT 3 [47]. A systematic review of the available epidemiological studies has been recently published: studies focusing on the relationship between TSH, T 3 , T 4 and different PFAS (in particular PFHxS, perfluorooctanoic acid, PFOS or perfluorononanoic acid) in pregnant women or young children were selected.…”

Section: Perfluoroalkylmentioning

confidence: 97%

Thyroid‐Disrupting Chemicals

Khetan¹

2014

Endocrine Disruptors in the Environment

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Endocrine disruptor compounds are exogenous agents able to interfere with a gland function, exerting their action across different functional passages, from the synthesis to the metabolism and binding to receptors of the hormone produced. Several issues, such as different levels and time of exposure and different action across different ages as well as gender, make the study of endocrine disruptors still a challenge. The thyroid is very sensitive to the action of disruptors, and considering the importance of a correct thyroid function for physical and cognitive functioning, addressing this topic should be considered a priority. In this review, we examined the most recent studies, many of them concentrating on maternal and child exposure, conducted to assess the impact of industrial chemicals which showed an influence on thyroid function. So far, the number of studies conducted on that topic is not sufficient to provide solid conclusions and lead to homogeneous guidelines. The lack of uniformity is certainly due to differences in areas and populations examined, the different conditions of exposures and the remarkable inter-subject variability. Nonetheless, the European Commission for Health and Food Safety is implementing recommendations to ensure that substances identified as endocrine disruptors will be withdrawn from the market.

show abstract

Assessing the relationship between perfluoroalkyl substances, thyroid hormones and binding proteins in pregnant women; a longitudinal mixed effects approach

Cited by 79 publications

References 34 publications

Thyroid Disrupting Chemicals

Thyroid Disrupting Chemicals

Factors Associated with Maternal Serum Levels of Perfluoroalkyl Substances and Organochlorines: A Descriptive Study of Parous Women in Norway and Sweden

Thyroid‐Disrupting Chemicals

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