Assessing the Regulatory Functions of LncRNA SNHG11 in Gastric Cancer Cell Proliferation and Migration

Zhao, Danyi; Chen, Huawei; Wang, Bing

doi:10.3389/fcell.2021.620476

Cited by 8 publications

(9 citation statements)

References 27 publications

(39 reference statements)

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“…Bioinformatics prediction is a powerful tool for the study of the function of miRNAs ( 20 ). To predict genes that may regulate SPP1, miRanda was used.…”

Section: Resultsmentioning

confidence: 99%

“…miR-433 regulates the expression of SPP1 mRNA and protein by directly binding to the 3'-UTR of SPP1 mRNA. Bioinformatics prediction is a powerful tool for the study of the function of miRNAs (20). To predict genes that may regulate SPP1, miRanda was used.…”

Section: Expression Of Mir-433 Is Reduced In Patients Who Have a Tibial Fracture In Combination With Craniocerebral Injury In Comparison mentioning

confidence: 99%

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Relationship between miRNA‑433 and SPP1 in the presence of fracture and traumatic brain injury

et al. 2021

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Limb fracture combined with traumatic brain injury (TBI) is one of the most common multiple injuries and patients often suffer from severe craniocerebral injury combined with long bone fracture of the limbs. The present study examined the expression of osteopontin (SPP1) in the tibial fracture callus and heterotopic ossification tissues in craniocerebral injury and investigated its relationship with miR-433. A total of 26 patients with tibial fracture combined with brain injury were included in the TBI group, and 26 patients with simple tibial fracture were included in the control group. The patients received immobilization treatment and callus was collected during the operation. At the time of steel plate removal tissue ossification samples from patients with heterotopic ossification were collected. Peripheral blood was collected from all patients on the morning of the operation day. Expression of miR-433 and SPP1 mRNA was determined by reverse transcription-quantitative PCR and SPP1 protein expression was measured by western blotting. Dual luciferase reporter assay was used to identify the direct interaction between miR-433 and SPP1 mRNA. The human osteoblast line hFOB1.19 was transfected with agomiR-433 to overexpress miR-433 and expression of SPP1 was also examined. TBI enhanced the incidence of callus formation and heterotopic ossification in patients with fracture but did not alter fracture healing time. SPP1 mRNA and protein expression was elevated in patients who had tibial fracture in combination with craniocerebral injury in comparison with controls By contrast, expression of miR-433 was decreased in patients who had tibial fracture in combination with craniocerebral injury in comparison with controls. miR-433 regulated the expression of SPP1 mRNA and protein by directly binding to the 3'-untranslated region of SPP1 mRNA. The present study suggests that SPP1 mRNA and protein levels are increased in the callus, heterotopic ossification tissues and plasma from patients with tibial fracture combined with brain injury in comparison with controls. This elevation may be due to the reduced expression of miR-433.

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“…Bioinformatics prediction is a powerful tool for the study of the function of miRNAs ( 20 ). To predict genes that may regulate SPP1, miRanda was used.…”

Section: Resultsmentioning

confidence: 99%

Section: Expression Of Mir-433 Is Reduced In Patients Who Have a Tibial Fracture In Combination With Craniocerebral Injury In Comparison mentioning

confidence: 99%

Relationship between miRNA‑433 and SPP1 in the presence of fracture and traumatic brain injury

et al. 2021

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“…The expression levels of FLNB-AS1 are positively correlated with the survival probability of breast cancer patients ( Zhang et al, 2020 ). The SNHG11/miR-184/CDC25A ceRNA network is a new biomarker for the diagnosis, treatment and prognosis of gastric cancer ( Zhao et al, 2021 ). A previous study has shown that HCG18 participates in vascular invasion of hepatocellular cancer by regulating immune cells ( Zhang et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

A Prognostic Pyroptosis-Related lncRNAs Risk Model Correlates With the Immune Microenvironment in Colon Adenocarcinoma

Xia

Yan

Shen

2021

Front. Cell Dev. Biol.

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Recent studies have indicated that long non-coding RNAs (lncRNAs) may participate in the regulation of tumor cell proptosis. However, the connection between lncRNA expression and pyroptosis remains unclear in colon adenocarcinoma (COAD). This study aims to explore and establish a prognostic signature of COAD based on the pyroptosis-related lncRNAs. We identify 15 prognostic pyroptosis-related lncRNAs (ZNF667-AS1, OIP5-AS1, AL118506.1, AF117829.1, POC1B-AS1, CCDC18-AS1, THUMPD3-AS1, FLNB-AS1, SNHG11, HCG18, AL021707.2, UGDH-AS1, LINC00641, FGD5-AS1 and AC245452.1) from the TCGA-COAD dataset and use them to construct the risk model. After then, this pyroptosis-related lncRNA signature is validated in patients from the GSE17536 dataset. The COAD patients are divided into low-risk and high-risk groups by setting the median risk score as the cut-off point and represented differences in the immune microenvironment. Hence, we construct the immune risk model based on the infiltration levels of ssGSEA immune cells. Interestingly, the risk model and immune risk model are both independent prognostic risk factors. Therefore, a nomogram combined risk score, immune risk score with clinical information which is meaningful in univariate and multivariate Cox regression analysis is established to predict the overall survival (OS) of COAD patients. In general, the signature consisted of 15 pyroptosis-related lncRNAs and was proved to be associated with the immune landscape of COAD patients.

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“…For example, the small nucleolar RNA host gene (SNHG) family members (e.g. SNHG6, SNHG11 and SNHG12) are newly recognized important lncRNAs that promote tumor progression through the ceRNA mechanism (22)(23)(24). Increased SNHG6 expression was significantly correlated with poor prognosis of both GC and CRC patients (22,25).…”

Section: Lncrna/circrna-mediated Cerna Crosstalks In Gics: Functional...mentioning

confidence: 99%

Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal Cancers

Chen

Zhao

et al. 2022

Front. Oncol.

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Gastrointestinal cancers (GICs) are high-incidence malignant tumors that seriously threaten human health around the world. Their complexity and heterogeneity make the classic staging system insufficient to guide patient management. Recently, competing endogenous RNA (ceRNA) interactions that closely link the function of protein-coding RNAs with that of non-coding RNAs, such as long non-coding RNA (lncRNA) and circular RNA (circRNA), has emerged as a novel molecular mechanism influencing miRNA-mediated gene regulation. Especially, ceRNA networks have proven to be powerful tools for deciphering cancer mechanisms and predicting therapeutic responses at the system level. Moreover, abnormal gene expression is one of the critical breaking events that disturb the stability of ceRNA network, highlighting the role of molecular biomarkers in optimizing cancer management and treatment. Therefore, developing prognostic signatures based on cancer-specific ceRNA network is of great significance for predicting clinical outcome or chemotherapy benefits of GIC patients. We herein introduce the current frontiers of ceRNA crosstalk in relation to their pathological implications and translational potentials in GICs, review the current researches on the prognostic signatures based on lncRNA or circRNA-mediated ceRNA networks in GICs, and highlight the translational implications of ceRNA signatures for GICs management. Furthermore, we summarize the computational approaches for establishing ceRNA network-based prognostic signatures, providing important clues for deciphering GIC biomarkers.

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Assessing the Regulatory Functions of LncRNA SNHG11 in Gastric Cancer Cell Proliferation and Migration

Cited by 8 publications

References 27 publications

Relationship between miRNA‑433 and SPP1 in the presence of fracture and traumatic brain injury

Relationship between miRNA‑433 and SPP1 in the presence of fracture and traumatic brain injury

A Prognostic Pyroptosis-Related lncRNAs Risk Model Correlates With the Immune Microenvironment in Colon Adenocarcinoma

Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal Cancers

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