Assessing the Psychological Impact of Next-Generation Sequencing Information in the Clinic: An Attempt to Map Terra Incognita?

Balancing External Validity and Concern for Psychosocial Harms in Translational Genetic Research

“…Although the prospect of psychosocial harms has dominated the debate, the existing evidence base suggests that disclosure does not cause major psychosocial harms in either pediatric or adult settings, and any psychosocial harm that does occur among adolescents is generally minor and self‐limited 13 . A systematic review of the psychosocial harms among children and adolescents concluded that the evidence base consistently signals a lack of psychosocial harms 14 .…”