Assessing the potency of oral polio vaccine kept outside of the cold chain during a national immunization campaign in Chad

Zipursky, Simona; Boualam, Liliane; Cheikh, Dah; Fournier-Caruana, Jacqueline; Hamid, Djabar; Janssen, Mathias; Kartoğlu, Ümit; Waeterloos, Geneviève; Ronveaux, Olivier

doi:10.1016/j.vaccine.2011.06.011

Cited by 22 publications

(16 citation statements)

References 1 publication

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“…Chad [75] Temperature excursion Use of vaccine vial monitors (small adhesive labels that gradually change color as the vial's cumulative exposure to heat increases over time) and field evaluation during an immunization campaign of the potency of monovalent oral polio vaccine type 3 kept at ambient temperatures. General [21] Techniques for temperature maintenance Prevent vaccine freezing by using cold water packs instead of ice for transport; using vaccine-vial monitors available at any time in the process of distribution and at the time the vaccine is administered.…”

Section: Oral Polio Vaccine Immunization Campaign Inmentioning

confidence: 99%

Introducing new vaccines in low- and middle-income countries: challenges and approaches

Guignard

Praet

Jusot

et al. 2019

Expert Review of Vaccines

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Introduction: The number of new vaccine introductions (NVIs) in low and middle-income countries (LMICs) has markedly increased since 2010, raising challenges to often overstretched and underfunded health care systems. Areas covered: We present an overview of some of these challenges, focusing on programmatic decisions, delivery strategy, information and communication, pharmacovigilance and post-licensure evaluation. We also highlight field-based initiatives that may facilitate NVI. Expert commentary: Some new vaccines targeting populations other than infants require alternative delivery strategies. NVIs impact upon existing supply chain management, in particular vaccines with novel characteristics. A lack of understanding about immunization and misconceptions may be detrimental to NVI, as well as insufficient or poorly trained health care workforce. Many barriers exist to achieving good vaccination coverage. Real-world evaluation of vaccine safety, effectiveness and impact in LMICs may be limited by lack of robust demographic and disease epidemiology data, as well as limited health care and surveillance infrastructure. A thorough planning phase is crucial to define the most suitable delivery strategy based on the vaccine's and country's specificities. A communication plan and social mobilization are essential. Implementation research and innovative approaches applied to logistics, delivery, communication and program evaluation can facilitate NVI. ARTICLE HISTORY

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Section: Oral Polio Vaccine Immunization Campaign Inmentioning

confidence: 99%

Introducing new vaccines in low- and middle-income countries: challenges and approaches

Guignard

Praet

Jusot

et al. 2019

Expert Review of Vaccines

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show abstract

“…Storing vaccines in a CTC could reduce the operational costs of mass vaccination campaigns against meningitis A while extending the reach of such campaigns to the populations in need. [5][6][7] The subject of the present study was a mass campaign against meningitis A that covered three regions of Chad and resulted in the vaccination of 1 807 158 individuals in December 2011. 8 Although 12 districts, 668 fixed health posts, 287 outreach posts and 55 mobile teams implemented the campaign, the infrastructure supporting the CCL system used throughout the campaign was weak.…”

Section: Introductionmentioning

confidence: 99%

Economic benefits of keeping vaccines at ambient temperature during mass vaccination: the case of meningitis A vaccine in Chad

Lydon

Zipursky²,

Tévi-Bénissan

et al. 2013

Bull. World Health Organ.

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“…In this regard, recent efforts by many countries to pilot or adopt protocols allowing vaccines storage at ambient temperatures for a specific period with an intent to minimize logistical challenges and to reduce or eliminate the need for cold chain supplies 41-45 are encouraging. Thus, during early adaption, availability of heat stable vaccines can facilitate less reliance on exact storage timing and refrigeration if not complete elimination of cold chain.…”

Section: Discussionmentioning

confidence: 99%

Rational design of heat stable lyophilized rotavirus vaccine formulations

Madhu

Sikriwal

Sharma

et al. 2018

Human Vaccines & Immunotherapeutics

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To develop a safe and efficacious heat-stable rotavirus vaccine, new lyophilized formulations were developed using rotavirus serotypes constituting RotaTeq®. A series of formulation compositions, differing in buffering agents, bulking agents, cryoprotectants, amino acids and divalent cations, were screened for their ability to provide stability to rotavirus serotypes during lyophilization and when stored under elevated temperatures for extended periods. Lead formulations and lyophilization cycles were further optimized. Stability profiles of thus optimized formulations showed their ability to retain the potency of rotavirus for > 36 months at 5°C, 20 months at 37°C, and 7 months at 45°C. The heat-stable lyophilized rotavirus formulations developed met the all critical quality attributes for appearance, heat-stability during storage, moisture content as well as pH, viability and stability after reconstitution and has great potential to be used as vaccine candidates for improving access in low-income countries.

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Assessing the potency of oral polio vaccine kept outside of the cold chain during a national immunization campaign in Chad

Cited by 22 publications

References 1 publication

Introducing new vaccines in low- and middle-income countries: challenges and approaches

Introducing new vaccines in low- and middle-income countries: challenges and approaches

Economic benefits of keeping vaccines at ambient temperature during mass vaccination: the case of meningitis A vaccine in Chad

Rational design of heat stable lyophilized rotavirus vaccine formulations

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