Assessing the oxidative potential of PAHs in ambient PM2.5 using the DTT consumption assay

Kramer, Amber L.; Dorn, Shelby; Perez, Allison; Roper, Courtney; Titaley, Ivan A.; Cayton, Kaylee; Cook, Ronald P.; Cheong, Paul Ha Yeon; Simonich, Staci L. Massey

doi:10.1016/j.envpol.2021.117411

Cited by 8 publications

(2 citation statements)

References 42 publications

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“…99 PM2.5 and PAHs contain reactive oxygen species (ROS) that can dysregulate the balance between antioxidants and oxidants in the body. 100 This imbalance results in increased oxidative stress, leading to cellular damage, DNA mutations and impaired repair mechanisms. The accumulation of oxidative stress in the pelvic area can further contribute to the growth, invasion and proliferation of endometriotic lesions.…”

Section: A Ir Pol Lu Tion a N D E N Dom Etr Iosismentioning

confidence: 99%

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Pollution and endometriosis: A deep dive into the environmental impacts on women's health

Vallée,

Ceccaldi,

Carbonnel

et al. 2023

BJOG

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BackgroundThe interaction between pollution and endometriosis is a pressing issue that demands immediate attention. The impact of pollution, particularly air and water pollution, or occupational hazards, on hormonal disruption and the initiation of endometriosis remains a major issue.ObjectivesThis narrative review aims to delve into the intricate connection between pollution and endometriosis, shedding light on how environmental factors contribute to the onset and severity of this disease and, thus, the possible public health policy implications.DiscussionEndocrine‐disrupting chemicals (EDCs) in pollutants dysregulate the hormonal balance, contributing to the progression of this major gynaecological disorder. Air pollution, specifically PM2.5 and PAHs, has been associated with an increased risk of endometriosis by enhancing chronic inflammation, oxidative stress, and hormonal imbalances. Chemical contaminants in water and work exposures, including heavy metals, dioxins, and PCBs, disrupt the hormonal regulation and potentially contribute to endometriosis. Mitigating the environmental impact of pollution is required to safeguard women’s reproductive health. This requires a comprehensive approach involving stringent environmental regulations, sustainable practices, responsible waste management, research and innovation, public awareness, and collaboration among stakeholders.ConclusionPublic health policies have a major role in addressing the interaction between pollution and endometriosis in a long‐term commitment.

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Section: A Ir Pol Lu Tion a N D E N Dom Etr Iosismentioning

confidence: 99%

“…PM2.5 and PAHs contain reactive oxygen species (ROS) that can dysregulate the balance between antioxidants and oxidants in the body 100 . This imbalance results in increased oxidative stress, leading to cellular damage, DNA mutations and impaired repair mechanisms.…”

Section: Air Pollution and Endometriosismentioning

confidence: 99%