Assessing the levels of immunoglobulins in the saliva of diabetic individuals with periodontitis using checkerboard immunodetection

Bachrach, Gilad; Muster, Z; I, Raz; Chaushu, Gavriel; Stabholz, Adam; Nussbaum, Gabriel; Gutner, M; Chaushu, Stella

doi:10.1111/j.1601-0825.2006.01345.x

Cited by 20 publications

(15 citation statements)

References 28 publications

(37 reference statements)

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“…27 Determination of possible alterations in whole saliva composition may be helpful for understanding the increased severity of PD in diabetic patients, as well as for diagnosing possible variations and defective host immune responses, including the secretion of s-IgA. 6,28 The predominance of low s-IgA values in diabetics that we observed may be related to the fact that to be effective, antibodies require the cooperation of other host-protective mechanisms. In DM patients, other immune components, such as polymorphonuclear leukocytes, are not fully functional.…”

Section: Discussionmentioning

confidence: 86%

“…3,4 In this context, analysis of whole saliva provides a simple and non-invasive method of evaluating the role of salivary IgA (s-IgA) levels in PD. [5][6][7] s-IgA represents the first line of defense against pathogens that colonize and invade mucosal surfaces, thus interfering with the development of PD at a very early, but very critical, stage. 8 Studies have suggested a protective role for s-IgA in patients with PD, 5,9,10 and low concentrations of s-IgA have been associated with severe forms of this disease.…”

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confidence: 99%

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Salivary IgA and periodontal treatment needs in diabetic patients

et al. 2011

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Section: Discussionmentioning

confidence: 86%

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confidence: 99%

Salivary IgA and periodontal treatment needs in diabetic patients

et al. 2011

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“…These findings are probably associated with the elevated levels of specific anti- S. mutans and anti-insulin antibody levels also observed in these patients. The determination of changes in whole saliva composition may be used to diagnose possible variations and defective host immune responses, including the secretion of s-IgA [ 22 ]. Similar results have been reported in other studies evaluating the salivary production of IgA antibodies in diabetic patients [ 20 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Salivary profile in diabetic patients: biochemical and immunological evaluation

et al. 2016

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BackgroundThe aim of this study was to evaluate the biochemical and immunological characteristics of saliva from diabetic patients compared to non-diabetic adults.MethodsEighty-eight diabetic adults and 39 non-diabetic adults (control) were included in the study. Glucose, urea, calcium, total protein and amylase were determined by a colorimetric method. The levels of secretory IgA and the IgA anti-Streptococcus mutans and anti-insulin IgA antibodies were measured by enzyme-linked immunosorbent assay (ELISA). Caries status was evaluated using the DMFT index.ResultsGlucose, urea, calcium, anti-S. mutans IgA, total IgA, and anti-insulin IgA were significantly higher in diabetic patients, whereas total protein and amylase levels were lower in these patients. There was no positive correlation between blood and salivary glucose levels in either group. Diabetic patients had a higher DMFT index.ConclusionsThe present study showed for the first time that IgA levels in diabetic patients’saliva, shows correlation with systemic biochemical parameters. Thus the saliva is an useful tool to follow the systemic health status in these patients.

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“…25 This is compatible with other findings showing that s-IgA levels were significantly higher in diabetic patients with periodontitis. 10,18,26 Using the gingival and modified sulcus bleeding indices, Malicka et al reported that the periodontal status of diabetic patients was significantly worse than that of healthy subjects. 12 Ranadheer et al showed that s-IgA levels were significantly higher among individuals with more than three DMFT.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Salivary Secretory Immunoglobulin A Levels in Diabetic Patients and Association with Oral and Dental Manifestations

Kakoei

Hosseini

Haghdoost

et al. 2015

SQUMJ

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abstract:Objectives: Oral and dental manifestations in diabetic patients can arise due to numerous factors, including elevated salivary secretory immunoglobulin A (s-IgA) levels. This study aimed to evaluate s-IgA concentrations in patients with type 2 diabetes mellitus (T2DM) and to investigate the association between s-IgA levels and oral and dental manifestations of T2DM. Methods: This cross-sectional descriptive study was carried out between October 2011 and September 2012 in Kerman, Iran, and included 260 subjects (128 patients with T2DM and 132 healthy controls). Unstimulated salivary samples were collected from all subjects and s-IgA levels were determined using the immunoturbidimetric method. The oral cavities and teeth of T2DM patients were evaluated for oral and dental manifestations. Results: Both diabetic and control subjects with higher concentrations of s-IgA had significantly higher numbers of decayed, missing or filled teeth (DMFT) and periodontal index (PDI) scores (P <0.050). s-IgA levels were significantly higher in subjects with oral candidiasis (P <0.050). Among diabetic patients, significantly higher s-IgA levels were concomitant with xerostomia and denture stomatitis (P ≤0.050). There were no significant differences between s-IgA concentrations and other oral or dental manifestations in either group. Conclusion: Individuals with a greater number of DMFT, a higher PDI score and oral candidiasis had significantly higher s-IgA levels. s-IgA levels were not significantly higher among diabetic patients in comparison to the control group. However, significantly higher s-IgA levels occurred with xerostomia and denture stomatitis in diabetic patients. In addition, s-IgA was significantly higher in patients with uncontrolled diabetes compared to those with controlled diabetes.

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Assessing the levels of immunoglobulins in the saliva of diabetic individuals with periodontitis using checkerboard immunodetection

Cited by 20 publications

References 28 publications

Salivary IgA and periodontal treatment needs in diabetic patients

Salivary IgA and periodontal treatment needs in diabetic patients

Salivary profile in diabetic patients: biochemical and immunological evaluation

Evaluation of Salivary Secretory Immunoglobulin A Levels in Diabetic Patients and Association with Oral and Dental Manifestations

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