Assessing the level of matrix metal proteinases 1,8,9, their tissue inhibitor, type I, in cases of odontogenic phlegmons

Abstract

The article considers the measured values of the level of MMP-1, MMP-8 and MMP-9, and of their tissue inhibitor Type I (TIMP-1) in the blood serum and mixed saliva samples of 78 patients (31 women -36.2 %, 47 men -63.8 %) suffering from odontogenic phlegmons in the oral and maxillofacial region. The study indicators were assessed through the enzyme-linked immunosorbent assay using diagnostic sets R&D Diagnostics Inc. (USA). An uncontrolled hyperactivation of metal proteinases as one of the components of the systemic infl ammatory response in case of phlegmon-related complications in the oral and maxillofacial region, as well as development of the sepsis syndrome were studied and it was determined that it results in distortion of the processes of reparative hystogeny and compel us to employ new approaches to the treatment of this type of patients (Tab. 2, Fig. 1

Overview of the Pathogenesis, Genetic, and Non-Invasive Clinical, Biochemical, and Scoring Methods in the Assessment of NAFLD

“…Fibrogenetic activity or extracellular matrix (ECM) turnover are typical changes in advanced-stage liver injury. Some of the most important factors in the process of extracellular matrix creation and fibrogenesis are changes in the activity of matrix metalloproteinases (MMP) and their specific inhibitors [100]. One of the most-studied matrix components HA, which is synthetized by stellate cells.…”