Assessing the impacts of dimethoate on rotifers′ reproduction through the pre-exposure history

Guo, Ruixin; Chen, Jianqiu

doi:10.1016/j.ecoenv.2014.10.023

Cited by 6 publications

(6 citation statements)

References 53 publications

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“…We hypothesize that a hormesis phenomenon could have been responsible for the unexpected stimulating effect of SIM in zebrafish fecundity. Hormesis has been documented in a wide range of vertebrates and invertebrates in response to a variety of stressors, being characterized as a stimulatory effect on biological parameters, particularly reproduction and/or growth, in response to low-doses of toxicants (Ayyanath et al, 2015; Calabrese, 1999; Correia, et al, 2001; Guo & Chen, 2015; Lefcort et al, 2008; Meador et al, 2011; Stebbing, 1982). This is view as an adaptive response that overcompensates the homeostatic regulatory control mechanisms induced by low levels of stress or damage, which will therefore be responsible to enhance the activities of the physiological systems (Calabrese & Baldwin, 2001).…”

Section: Discussionmentioning

confidence: 99%

Chronic environmentally relevant levels of Simvastatin induces non-monotonic responses in Zebrafish (Danio rerio)

Barros¹,

Montes

Quintana

et al. 2018

Preprint

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Simvastatin (SIM), a hypocholesterolaemic compound, is among the most prescribed pharmaceuticals for cardiovascular disease prevention worldwide. Several studies have shown that acute exposure to SIM is able to produce multiple adverse effects in aquatic organisms. However, uncertainties still remain regarding the chronic effects of SIM in aquatic ecosystems. Therefore, the present study aimed to investigate the effects of SIM in the model freshwater teleost zebrafish (Danio rerio) following a chronic exposure (90 days) to environmentally relevant concentrations ranging from 8 ng/L to 1000 ng/L. This study used a multi-parametric approach integrating distinct ecological-relevant endpoints, i.e. survival, growth, reproduction and embryonic development, with biochemical markers (cholesterol and triglycerides). Furthermore, Real Time PCR was used to analyse the transcription levels of key genes involved in the mevalonate pathway (hmgcra, cyp51, and dhcr7). Globally, SIM induced several non-monotonic dose-responses; embryonic development, biochemical and molecular markers, were significantly impacted in the low-intermediate concentrations, 40 ng/L and 200 ng/L, whereas no effects were recorded for the highest tested SIM levels (1000 ng/L). Taken together, these findings expand our understanding of statins effects in teleost’s, demonstrating significant impacts at environmentally relevant concentrations. The findings highlight the importance of addressing the effects of chemicals under chronic low-level concentrations.Graphical abstractHighlightsSeveral uncertainties exist regarding simvastatin mode of action in non-target organismsThis work integrates D. rerio multi-level responses after long-term exposure to simvastatinSimvastatin impacted cholesterol/triglycerides levels and transcript levels of genes related to mevalonate pathway.Parental exposure to simvastatin induced offspring embryonic malformations.Embryonic abnormalities, biochemical and molecular data did follow a non-monotonic curve.

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Section: Discussionmentioning

confidence: 99%

Chronic environmentally relevant levels of Simvastatin induces non-monotonic responses in Zebrafish (Danio rerio)

Barros¹,

Montes

Quintana

et al. 2018

Preprint

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“…From 2004, the monogonont rotifer B. calyciflorus has been included as a standard freshwater bioassay species by the American Society for Testing and Materials [14]. Thereafter, toxicity evaluations using Brachionus have been successfully applied to heavy metals, pesticides, and other chemical compounds [15][16][17][18][19]. Because of their wide distribution and inevitable contact in aquatic ecosystems, it is necessary to assess the effects of DDT and dicofol on Brachionus rotifers.…”

mentioning

confidence: 99%

Effects of DDT and Dicofol on Life Table Demography of the Freshwater Rotifer <i>Brachionus calyciflorus</i> Pallas

Xu¹,

Xi²,

Wang³

2020

Pol. J. Environ. Stud.

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Dichlorodiphenyltrichloroethanes (DDTs) are effective pesticides and have been widely used to control agricultural, animal and human insect diseases since the Second World War. In China, the total production of DDTs reached 270,000 tons from 1960 to 1980 [1]. DDTs are typical persistent organic pollutants (POPs). Due to their chronic toxicity, environmental persistence, and bioaccumulative abilities, DDTs have raised great environmental concerns in past decades [2]. Although

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“…Regarding MPA, this drug seems to present a very high risk to freshwater biota, with an RQ of 965 (Table 1). However, previous studies have reported distinct classifications for MPA concerning the risk it might pose to different organisms (Franquet-Griell et al 2017a, Franquet-Griell et al 2017b, Giebułtowicz and Nałęcz-Jawecki 2016, Gouveia et al 2019, Guo 2015, Saab et al 2021, Santos et al 2017. For example, Saab et al (2021) compared the different risk classifications given to MPA over the years, ranging from potentially hazardous to high-risk compound.…”

Section: Risk Quotient (Rq)mentioning

confidence: 99%

“…In Portugal, for example, both MPA and MMF were, respectively, the first and fourth most consumed cytostatic drugs between the period of 2007-2015, with values ranging between 1810 and 2380 kg y -1 for MMF and 70.4 and 289 kg y −1 for MPA (Santos et al 2017). More strikingly, in Spain, the consumption of MPA alone increased from 894 to 12,296 kg y −1 within the period of 2010-2015(Franquet-Griell et al 2017b). Once administered, MMF is rapidly and completely hydrolyzed in the liver and intestine, generating its active metabolite-MPA, which acts on the activity of inosine monophosphate dehydrogenase ultimately leading to the suppression of DNA and RNA synthesis and the proliferation of T and B lymphocytes (Parnham 2019).…”

Section: Introductionmentioning

confidence: 99%

Contributions towards the hazard evaluation of two widely used cytostatic drugs

Monteiro

Venâncio

Francisco

et al. 2022

Environ Sci Pollut Res

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Cytostatic drugs are one of the most important therapeutic options for cancer, a disease that is expected to affect 29 million individuals by 2040. After being excreted, cytostatics reach wastewater treatment plants (WWTPs), which are unable to efficiently remove them, and consequently, they will be released into the aquatic environment. Due to the highly toxic properties of cytostatics, it is particularly relevant to evaluate their potential ecological risk. Yet, cytostatics toxicity data is still not available for various species. In this work, the ecotoxicity of two widely consumed cytostatics, cyclophosphamide (CYP-as a model cytostatic) and mycophenolic acid (MPA-as a priority cytostatic), was evaluated on three freshwater species-Raphidocelis subcapitata, Brachionus calyciflorus, and Danio rerio, and the risk quotient (RQ) was assessed. Both drugs significantly affected the yield and growth inhibition of the microalgae, while for rotifers, the least sensitive species, only significant effects were registered for CYP. These drugs also caused significant effects on the mortality and morphological abnormalities on zebrafish. The estimation of the RQ discloses that CYP seems to pose a low risk to aquatic biota while MPA poses a very high risk. Altogether, these results emphasize the need for more complete environmental risk assessments, to properly prioritize and rank cytostatics according to their potentially toxic effects on the environment and aquatic biota.

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Assessing the impacts of dimethoate on rotifers′ reproduction through the pre-exposure history

Cited by 6 publications

References 53 publications

Chronic environmentally relevant levels of Simvastatin induces non-monotonic responses in Zebrafish (Danio rerio)

Chronic environmentally relevant levels of Simvastatin induces non-monotonic responses in Zebrafish (Danio rerio)

Effects of DDT and Dicofol on Life Table Demography of the Freshwater Rotifer <i>Brachionus calyciflorus</i> Pallas

Contributions towards the hazard evaluation of two widely used cytostatic drugs

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