“…A retrospective study 24 compared 3%, 6%, and 12% HTS in 43 children with sTBI and, surprisingly, found a concentration-dependent reduction in ICP of 4.5, 6.6, and 10.5 mm Hg, respectively, despite using equimolar doses of the medications. Three studies [25][26][27] addressed prehospital or emergency department use. Finally, 2 systematic reviews 28,29 concluded that there was a paucity of high-quality data, making it difficult to draw conclusions.…”