Assessing the functional roles of coevolving PHD finger residues
Shraddha Basu,
Ujwal Subedi,
Marco Tonelli
et al.
Abstract:Although in silico folding based on coevolving residue constraints in the deep‐learning era has transformed protein structure prediction, the contributions of coevolving residues to protein folding, stability, and other functions in physical contexts remain to be clarified and experimentally validated. Herein, the PHD finger module, a well‐known histone reader with distinct subtypes containing subtype‐specific coevolving residues, was used as a model to experimentally assess the contributions of coevolving res… Show more
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