Assessing the effects of the cytostatic drug 5-Fluorouracil alone and in a mixture of emerging contaminants on the mussel Mytilus galloprovincialis

Gonçalves, Joanna M.; Beckmann, Clara; Bebianno, Maria João

doi:10.1016/j.chemosphere.2022.135462

Cited by 14 publications

(2 citation statements)

References 76 publications

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“…Mollusks, the taxa under study in this work, constitute a widespread group of invertebrates inhabiting a wide variety of habitats (freshwater, marine and terrestrial environments). Their study has become relevant because they are valuable as bioindicators (Chaudhary et al, 2022;De Silva et al, 2022;Goncalves et al, 2022;Jong et al, 2022;Lemos et al, 2022;Pokhrel et al, 2022) and because many mollusk species are important in the aquaculture industry, as is the case for mussels, oysters, clams and abalones, representing 23% of total aquaculture production (FAO, 2022). It is important to highlight the habit of consuming some uncooked food, being a potential risk for human health (Prato et al, 2004;Guyader et al, 2008;Lattos et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Metatranscriptomics unmasks Mollusca virome with a remarkable presence of rhabdovirus in cephalopods

et al. 2023

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IntroductionMollusks play a significant role in marine ecosystems and have economic value for aquaculture. Sometimes, unexpected and unexplained mortalities among mollusks have been described. The role of potential pathogens such as viruses remains unknown due to the lack of molluscan cell cultures, which is one of the major drawbacks to determining the viral role in such mortalities. Several oceanographic studies have suggested a high abundance of viruses in the oceans. Virus identification and understanding of viral interaction with organisms in marine ecosystems are in their infancy. Metatranscriptomics could become a useful tool to identify viruses using a shotgun approach and the growing number of viral genomes and sequences deposited in public databases.MethodsIn this work, several bioinformatics approaches were set up to screen Mollusca RNA sequences to find and confirm viral traces in their transcriptomes. This meta-analysis included an extensive search of SRA datasets belonging to mollusks available in the NCBI database, selecting a total of 55 SRA datasets that were further analyzed searching for viral sequences.ResultsTwenty-two bivalves, 19 cephalopods and 16 gastropods from 16 geographical origins and 17 different tissues were considered. The domain search approach was the most productive method to find viral sequences. This virus search showed that Cephalopoda samples (Idiosepius notoides and Amphioctopus fangsiao) exhibited the highest number of virus identifications. Some of the detected viral sequences were similar or identical to others previously identified. However, 33 putative new viruses were identified and analyzed phylogenetically when the RdRp domain was available. Specifically, Cephalopoda samples showed a considerable number of viruses belonging to the Rhabdoviridae family.

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Section: Discussionmentioning

confidence: 99%

Metatranscriptomics unmasks Mollusca virome with a remarkable presence of rhabdovirus in cephalopods

et al. 2023

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“…To address the problem of combined pollution in the presence of ENPs, a series of relevant experimental and theoretical research works have been carried out [ 5 , 6 ]. Some studies have shown that the presence of ENPs increases the biological impact of other contaminants [ 7 , 8 ]; others have shown that the presence of ENPs decreases the biological impact of other contaminants [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

An Insight into the Combined Toxicity of 3,4-Dichloroaniline with Two-Dimensional Nanomaterials: From Classical Mixture Theory to Structure-Activity Relationship

Wang

2023

IJMS

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The assessment and prediction of the toxicity of engineered nanomaterials (NMs) present in mixtures is a challenging research issue. Herein, the toxicity of three advanced two-dimensional nanomaterials (TDNMs), in combination with an organic chemical (3,4-dichloroaniline, DCA) to two freshwater microalgae (Scenedesmus obliquus and Chlorella pyrenoidosa), was assessed and predicted not only from classical mixture theory but also from structure-activity relationships. The TDNMs included two layered double hydroxides (Mg-Al-LDH and Zn-Al-LDH) and a graphene nanoplatelet (GNP). The toxicity of DCA varied with the type and concentration of TDNMs, as well as the species. The combination of DCA and TDNMs exhibited additive, antagonistic, and synergistic effects. There is a linear relationship between the different levels (10, 50, and 90%) of effect concentrations and a Freundlich adsorption coefficient (KF) calculated by isotherm models and adsorption energy (Ea) obtained in molecular simulations, respectively. The prediction model incorporating both parameters KF and Ea had a higher predictive power for the combined toxicity than the classical mixture model. Our findings provide new insights for the development of strategies aimed at evaluating the ecotoxicological risk of NMs towards combined pollution situations.

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Advanced Treatment Methods for the Emerging Contaminants: An Insight into the Removal of Anticancer Drugs

Sivodia

Sinha

2023

Energy, Environment, and Sustainability

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Assessing the effects of the cytostatic drug 5-Fluorouracil alone and in a mixture of emerging contaminants on the mussel Mytilus galloprovincialis

Cited by 14 publications

References 76 publications

Metatranscriptomics unmasks Mollusca virome with a remarkable presence of rhabdovirus in cephalopods

Metatranscriptomics unmasks Mollusca virome with a remarkable presence of rhabdovirus in cephalopods

An Insight into the Combined Toxicity of 3,4-Dichloroaniline with Two-Dimensional Nanomaterials: From Classical Mixture Theory to Structure-Activity Relationship

Advanced Treatment Methods for the Emerging Contaminants: An Insight into the Removal of Anticancer Drugs

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