Assessing the Effects of Metabolic Disruption, Body Mass Index and Inflammation on Depressive Symptoms in Post-COVID-19 Condition: A Randomized Controlled Trial on Vortioxetine

Kwan, Angela T. H.; Guo, Ziji; Ceban, Felicia; Le, Gia Han; Wong, Sabrina; Teopiz, Kayla M.; Rhee, Taeho Greg; Ho, Roger; Di Vincenzo, Joshua D.; Badulescu, Sebastian; Meshkat, Shakila; Cao, Bing; Rosenblat, Joshua D.; d’Andrea, Giacomo; Dev, Donovan A.; Phan, Lee; Subramaniapillai, Mehala; McIntyre, Roger S.

doi:10.1007/s12325-024-02826-9

Adv Ther

2024

DOI: 10.1007/s12325-024-02826-9

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Assessing the Effects of Metabolic Disruption, Body Mass Index and Inflammation on Depressive Symptoms in Post-COVID-19 Condition: A Randomized Controlled Trial on Vortioxetine

Angela T. H. Kwan,

Ziji Guo,

Felicia Ceban

et al.

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2024

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The prevalence, determinants, and consequences of post‐COVID in healthcare workers: A cross‐sectional survey

Saade,

Didier,

Cha

et al. 2024

Journal of Medical Virology

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Data on post‐coronavirus disease (COVID) in healthcare workers (HCWs) are scarce. We aimed to assess prevalence, determinants, and consequences of post‐COVID in HCWs. In fall 2022, we performed a cross‐sectional survey in a tertiary care hospital with a web‐based questionnaire sent to HCWs. Post‐COVID was defined as persistent/new symptoms 3 months after acute COVID. Propensity score weighting was performed to assess the impact of post‐COVID on return‐to‐work. 1062 HCWs completed the questionnaire, 713 (68%) reported at least one COVID, and 109 (10%) met the definition for post‐COVID, with workplace contamination reported in 51 (47%). On multivariable analysis, risk factors for post‐COVID were female gender (p = 0.047), ≥50 years (p = 0.007), immunosuppression (p = 0.004), ≥2 COVID episodes (p = 0.003), and ≥5 symptoms during acute COVID (p = 0.005). Initial sick leave was prescribed for 94 HCWs (86% post‐COVID), for a median duration of 7 [7–9] days, and extended for 23. On return‐to‐work, 91 (84%) had residual symptoms, primarily asthenia/fatigue (72%) and cognitive impairment (25%). Cognitive impairment at return‐to‐work was associated with post‐COVID. Ten HCWs (9%) received a medical diagnosis of post‐COVID, 8 consulted the occupational physician, and four required work adaptation. Post‐COVID affected 10% of HCWs. Long‐term consequences included repeated sick leaves and residual symptoms on return‐to‐work.

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The prevalence, determinants, and consequences of post‐COVID in healthcare workers: A cross‐sectional survey

Saade,

Didier,

Cha

et al. 2024

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

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Assessing the Effects of Metabolic Disruption, Body Mass Index and Inflammation on Depressive Symptoms in Post-COVID-19 Condition: A Randomized Controlled Trial on Vortioxetine

Cited by 1 publication

References 28 publications

The prevalence, determinants, and consequences of post‐COVID in healthcare workers: A cross‐sectional survey

The prevalence, determinants, and consequences of post‐COVID in healthcare workers: A cross‐sectional survey

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