Assessing the effects of inulin‐type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta‐analysis of randomized controlled trials

Li, Liangkui; Li, Peng; Xu, Li

doi:10.1002/fsn3.2403

Cited by 25 publications

(16 citation statements)

References 94 publications

(98 reference statements)

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“…In addition to the immunomodulatory effects of polysaccharides, specifically arabinoxylan, a previous study showed that they regulate the level of lipopolysaccharides in the blood in the case of high‐fat diets (Li et al., 2019). Moreover, inulin‐type fructan Wich is a prebiotic polysaccharide that increases HDL cholesterol, decreases LDL cholesterol, and lowers blood glucose and triglycerides in diabetics patients (Li et al., 2021).…”

Section: Resultsmentioning

confidence: 99%

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In vitro study of the effect of quinoa and quinoa polysaccharides on human gut microbiota

Zeyneb

Pei

Cao

et al. 2021

Food Science & Nutrition

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It has been shown that whole grains and dietary fiber are important for their fermentation characteristics in the large intestine, drawing more and more attention to quinoa and quinoa polysaccharides. In this study, we evaluated the prebiotic effect of quinoa seeds and quinoa polysaccharides after human simulated digestion. The modulatory effect of the quinoa and quinoa polysaccharides (QPs) on the gut microbiota was evaluated by the in vitro fermentation using human fecal microbiota. The yield of polysaccharides extraction was 15.45%. The digestibility of the cooked and uncooked quinoa after simulation of human digestion was 69.04% and 64.09%, respectively. The effect on the microbiota composition and their metabolic products was determined by the assessment of pH, short‐chain fatty acids (SCFAs), and changes in the bacterial population. After 24 hr anaerobic incubation, the total SCFAs of cooked, uncooked quinoa, and quinoa polysaccharides were 82.99, 77.11, and 82.73 mM, respectively with a pH decrease. At the phylum, genus, and class level, it has been found that the quinoa substrates enhance the growth of certain beneficial bacteria such as Prevotella and Bacteroides . Quinoa polysaccharides can be considered prebiotic due to their ability to increase Bifidobacterium and Collinsella . Principal component analysis (PCA) showed that there was a distinct modulating effect on the fecal microbiota which represents different distribution. Our research suggests that quinoa and quinoa polysaccharides have a prebiotic potential due to their association with the positive shifts in microbiota composition and short‐chain fatty acids production, which highlights the importance of further studies around this topic.

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Section: Resultsmentioning

confidence: 99%

“…Moreover, inulin-type fructan Wich is a prebiotic polysaccharide that increases HDL cholesterol, decreases LDL cholesterol, and lowers blood glucose and triglycerides in diabetics patients (Li et al, 2021).…”

Section: Analysis Of Microbial Communities With Different Substratesmentioning

confidence: 99%

In vitro study of the effect of quinoa and quinoa polysaccharides on human gut microbiota

Zeyneb

Pei

Cao

et al. 2021

Food Science & Nutrition

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“…The dosages and durations of dietary fiber intervention ranged from 3 g/day to 30 g/day (except for one study, which used guar gum at 15 mg/day, and another study that used brown rice at 225 g/d), and 4 to 13 weeks, respectively. Twenty-two meta-analyses were performed in China ( 23 , 25 – 27 , 29 – 31 , 35 – 37 , 42 , 43 , 45 , 49 , 51 , 53 – 56 , 69 – 71 ), six in Iran ( 24 , 32 – 34 , 38 , 40 ), four in the UK ( 13 , 39 , 41 , 57 ), one in Australia ( 14 ), eight in Canada ( 44 , 46 , 47 , 50 , 52 , 58 , 62 , 72 ), five in the USA ( 48 , 60 , 65 , 67 , 68 ), one in Brazil ( 59 ), one in Ireland ( 61 ), one in South Africa ( 63 ), one in Italy ( 64 ), one in the Netherlands ( 66 ), and one in Malaysia ( 28 ).…”

Section: Resultsmentioning

confidence: 99%

Associations between dietary fiber intake and cardiovascular risk factors: An umbrella review of meta-analyses of randomized controlled trials

Zhang

Qian

et al. 2022

Front. Nutr.

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Although several meta-analyses have revealed the beneficial effects of dietary fiber intake on human health, some have reported inconsistent findings. The purpose of this work was to perform an umbrella meta-analysis to evaluate the relevant evidence and elucidate the effect of dietary fiber intake on glycemic control, lipid profiles, systematic inflammation, and blood pressure. Eligible studies were searched in several electronic databases, including Web of Science, PubMed, Scopus, and the Cochrane Library, up to March 2022. A total of 52 meta-analyses involving 47,197 subjects were identified to assess the pooled effect size. Overall, higher dietary fiber intake was significantly associated with reductions in parameters involving glycemic control, including fasting plasma glucose (ES = −0.55, 95% CI: −0.73, −0.38, P < 0.001), fasting plasma insulin (ES = −1.22, 95% CI: −1.63, −0.82, P < 0.001), homeostasis model assessment of insulin resistance (HOMA-IR) (ES = −0.43, 95% CI: −0.60, −0.27, P < 0.001), and glycosylated hemoglobin (HbA1c) (ES = −0.38, 95% CI: −0.50, −0.26, P < 0.001). In terms of lipid profiles, higher dietary fiber intake was associated with significant reductions in the serum level of total cholesterol (ES = −0.28, 95% CI: −0.39, −0.16, P < 0.001) and low-density lipoprotein cholesterol (ES = −0.25, 95% CI: −0.34, −0.16, P < 0.001), but not triglycerides (ES = −0.001, 95% CI: −0.006, 0.004, P = 0.759) and high-density lipoprotein cholesterol (ES = −0.002, 95% CI: −0.004, 0.000, P = 0.087). Higher dietary fiber intake was also significantly associated with improved tumor necrosis factor-alpha serum levels (ES = −0.78, 95% CI: −1.39, −0.16, P = 0.013), while no significant effect was observed for C-reactive protein (ES = −0.14, 95% CI: −0.33, 0.05, P = 0.156). Finally, blood pressure was also significantly improved following higher dietary fiber intake (systolic blood pressure: ES = −1.72, 95% CI: −2.13, −1.30, P < 0.001; diastolic blood pressure: ES = −0.67, 95% CI: −0.96, −0.37, P < 0.001). Subgroup analysis revealed that the study population and type of dietary fiber could be partial sources of heterogeneity. In conclusion, the present umbrella meta-analysis provides evidence for the role of dietary fiber supplementation in the improvement of established cardiovascular risk factors.

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“…However, a recent systematic review with 27 probiotic interventions (Lactobacillus, Bifidobacterium, Clostridium and Akkermansia) reported contradictory results regarding the effects of certain probiotics on amelioration of IR, suggesting the need for long-term RCTs in people with obesity and cardiometabolic risk [410]. Results from two systematic reviews and meta-analyses of 33 RCTs in healthy, overweight/obese, prediabetes, T2DM, and hyperlipidemic subjects examining the metabolic effects of inulin-type fructan intake, reported a reduction in blood glucose, total cholesterol, and triglyceride concentrations in people with diabetes, although the mechanisms were inconclusive without differences from controls on body weight and blood insulin and with data showing large heterogeneity [411,412].…”

Section: Probiotic Dairy Foodsmentioning

confidence: 99%

Effects of Diet, Lifestyle, Chrononutrition and Alternative Dietary Interventions on Postprandial Glycemia and Insulin Resistance

et al. 2022

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As years progress, we are found more often in a postprandial than a postabsorptive state. Chrononutrition is an integral part of metabolism, pancreatic function, and hormone secretion. Eating most calories and carbohydrates at lunch time and early afternoon, avoiding late evening dinner, and keeping consistent number of daily meals and relative times of eating occasions seem to play a pivotal role for postprandial glycemia and insulin sensitivity. Sequence of meals and nutrients also play a significant role, as foods of low density such as vegetables, salads, or soups consumed first, followed by protein and then by starchy foods lead to ameliorated glycemic and insulin responses. There are several dietary schemes available, such as intermittent fasting regimes, which may improve glycemic and insulin responses. Weight loss is important for the treatment of insulin resistance, and it can be achieved by many approaches, such as low-fat, low-carbohydrate, Mediterranean-style diets, etc. Lifestyle interventions with small weight loss (7–10%), 150 min of weekly moderate intensity exercise and behavioral therapy approach can be highly effective in preventing and treating type 2 diabetes. Similarly, decreasing carbohydrates in meals also improves significantly glycemic and insulin responses, but the extent of this reduction should be individualized, patient-centered, and monitored. Alternative foods or ingredients, such as vinegar, yogurt, whey protein, peanuts and tree nuts should also be considered in ameliorating postprandial hyperglycemia and insulin resistance. This review aims to describe the available evidence about the effects of diet, chrononutrition, alternative dietary interventions and exercise on postprandial glycemia and insulin resistance.

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Assessing the effects of inulin‐type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta‐analysis of randomized controlled trials

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 25 publications

References 94 publications

In vitro study of the effect of quinoa and quinoa polysaccharides on human gut microbiota

In vitro study of the effect of quinoa and quinoa polysaccharides on human gut microbiota

Associations between dietary fiber intake and cardiovascular risk factors: An umbrella review of meta-analyses of randomized controlled trials

Effects of Diet, Lifestyle, Chrononutrition and Alternative Dietary Interventions on Postprandial Glycemia and Insulin Resistance

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