Evidence-based education is gaining momentum in France. The Ministry of Education has created an expert committee (le Conseil Scientifique de l’Education Nationale) which aims at: (1) compiling, synthesizing, publicising evidence on learning mechanisms; (2) building bridges between research and practice to evaluate educational practices and create practical tools for teachers. Teachers are expected to possess a strong foundation in scientific literacy, to remain perpetually informed and to meaningfully participate in research. It is unclear if and how the CSEN vision is received by teachers. We investigated: (1) Where French primary school teachers’ knowledge about learning comes from; (2) How they define ‘evidence-based’ education; (3) How they know that a pedagogical method ‘works’; (4) What conditions they believe are important for a successful collaboration between researchers and teachers. Fourteen teachers participated in semi-structured focus groups. Thematic analyses shed light on the four research questions. First, teachers were frustrated about their professional training and proactively used complementary resources. Second, although most teachers were familiar with research, several of them saw scientists as belonging to a different ‘crew’. Teachers use a diversity of methods to evaluate pedagogical practices, considering that research evidence brings legitimacy to their decisions, yet does not replace their professional intuition. Third, teachers use evaluation tools, a positive classroom climate and observations of children taking ownership of their learning as evidence of good practice. Fourth, they would like to work with scientists to identify research measures and investigate their own pedagogical research questions, building flexible and direct partnerships. Results from the focus groups are discussed with teachers to co-create a larger-scale survey and further inform local professional development offers.