Assessing the benefits of composting poultry manure in reducing antimicrobial residues, pathogenic bacteria, and antimicrobial resistance genes: a field-scale study

Esperón, Fernando; Albero, Beatriz; Ugarte‐Ruiz, María; Domı́nguez, Lucas; Carballo, Matilde; Tadeo, José L.; Delgado, María del Mar; Moreno, Miguel A.; Torre, Ana de la

doi:10.1007/s11356-020-09097-1

Cited by 31 publications

(26 citation statements)

References 56 publications

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“…For example, chlortetracycline and sulfadiazine residues were completely removed from antibiotic-spiked swine manure within 21 and 3 days, respectively, while 17-31% of spiked ciprofloxacin remained in the composting mass. Similar results were observed by Esperón et al in antibiotic-spiked poultry manure, with a 90% decrease in the concentration of ciprofloxacin and doxycycline after composting for 3 weeks [141]. In addition, β-lactams have a very sensitive ring structure which is easily cleaved by the phosphate, ammonia and hydroxyl ions present in the composting environment, resulting in a degradation product with no antimicrobial activity [142].…”

Section: Manure Treatmentsupporting

confidence: 78%

“…Several studies have investigated changes in ARG and MGE content during composting, but the conclusions are inconsistent. For instance, the abundance of tetC, tetG, tetW, tetX, sul2, drfA1, drfA7, ermB, ermF, ermQ, ermX and intI1 genes after chicken manure composting with the addition of bamboo charcoal for 26 days was found to decrease significantly, while sul1 increased [144]; the composting of poultry manure for 10 weeks also led to a significant reduction of tetA, tetB tetK, tetM, tetQ, tetS, tetW, ermB, qnrS and bla TEM genes and an increased abundance of sul1, sul2, tetY and aadA genes [141]. The absolute abundances of intI1 and intI2, genes coding for integron integrases, and different erm, sul and tet ARGs were reduced by up to 45% after the composting of pig manure with cotton stalks, with good aeration, for 40 days [143].…”

Section: Manure Treatmentmentioning

confidence: 92%

“…Composting is a spontaneous and biological process of aerobic digestion that involves the mineralization and humification of organic matter [12,140]. This bio-oxidative process involves environmental microorganisms, which break down organic materials, resulting in the formation of a stable final product, known as compost [12,140,141]. Composting is a suitable option for manure management, which implies the reduction of volume of the animal wastes and the elimination or reduction of pathogenic microorganisms, with economic, environmental and public health advantages.…”

Section: Manure Treatmentmentioning

confidence: 99%

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Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Lima

Domingues

Silva

2020

Veterinary Sciences

111

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The increasing demand for animal-derived foods has led to intensive and large-scale livestock production with the consequent formation of large amounts of manure. Livestock manure is widely used in agricultural practices as soil fertilizer worldwide. However, several antibiotic residues, antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria are frequently detected in manure and manure-amended soils. This review explores the role of manure in the persistence and dissemination of ARGs in the environment, analyzes the procedures used to decrease antimicrobial resistance in manure and the potential impact of manure application in public health. We highlight that manure shows unique features as a hotspot for antimicrobial gene dissemination by horizontal transfer events: richness in nutrients, a high abundance and diversity of bacteria populations and antibiotic residues that may exert a selective pressure on bacteria and trigger gene mobilization; reduction methodologies are able to reduce the concentrations of some, but not all, antimicrobials and microorganisms. Conjugation events are often seen in the manure environment, even after composting. Antibiotic resistance is considered a growing threat to human, animal and environmental health. Therefore, it is crucial to reduce the amount of antimicrobials and the load of antimicrobial resistant bacteria that end up in soil.

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Section: Manure Treatmentsupporting

confidence: 78%

Section: Manure Treatmentmentioning

confidence: 92%

Section: Manure Treatmentmentioning

confidence: 99%

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Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Lima

Domingues

Silva

2020

Veterinary Sciences

111

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“…The transposases gene tnpA was strongly associated with certain ARG types including aadA , a aminoglycoside resistance gene that is often associated with various pathogens including E. faecalis and E. coli [81] , [82] . A recent study showed increased abundance of aadA gene during 10 weeks of poultry manure composting [83] . Interestingly aadA was a hub gene in our network analysis, and it co-occurred with several different ARGs.…”

Section: Discussionmentioning

confidence: 99%

Spatial and temporal dynamics of microbiomes and resistomes in broiler litter stockpiles

Gupta

Avidov

Kattusamy

et al. 2021

Computational and Structural Biotechnology Journal

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“…are Gram negative, rod shaped, and facultative anaerobic bacteria which are part of the family Enterobacteriaceae (Beattie et al, 2020;Esperón et al, 2020;Massé et al, 2021). The well-studied species include P. stuartii, P. alcalifaciens, and, P. rettgeri with these bacteria linked to gastroenteritis, Urinary Tract Infections (UTIs) and bacteraemia (Holman et al, 2016;Chuppava et al, 2019;Esperón et al, 2020;Yoshizawa et al, 2020;Congilosi and Aga, 2021). Providencia spp.…”

Section: Providencia Sppmentioning

confidence: 99%

The Fate of Foodborne Pathogens in Manure Treated Soil

et al. 2021

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The aim of this review was to provide an update on the complex relationship between manure application, altered pathogen levels and antibiotic resistance. This is necessary to protect health and improve the sustainability of this major farming practice in agricultural systems based on high levels of manure production. It is important to consider soil health in relation to environment and land management practices in the context of the soil microflora and the introduction of pathogens on the health of the soil microbiome. Viable pathogens in manure spread on agricultural land may be distributed by leaching, surface run-off, water source contamination and contaminated crop removal. Thus it is important to understand how multiple pathogens can persist in manures and on soil at farm-scale and how crops produced under these conditions could be a potential transfer route for zoonotic pathogens. The management of pathogen load within livestock manure is a potential mechanism for the reduction and prevention of outbreaks infection with Escherichia coli, Listeria Salmonella, and Campylobacter. The ability of Campylobacter, E. coli, Listeria and Salmonella to combat environmental stress coupled with their survival on food crops and vegetables post-harvest emphasizes the need for further study of these pathogens along with the emerging pathogen Providencia given its link to disease in the immunocompromised and its’ high levels of antibiotic resistance. The management of pathogen load within livestock manure has been widely recognized as a potential mechanism for the reduction and prevention of outbreaks infection but any studies undertaken should be considered as region specific due to the variable nature of the factors influencing pathogen content and survival in manures and soil. Mediocre soils that require nutrients could be one template for research on manure inputs and their influence on soil health and on pathogen survival on grassland and in food crops.

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Assessing the benefits of composting poultry manure in reducing antimicrobial residues, pathogenic bacteria, and antimicrobial resistance genes: a field-scale study

Cited by 31 publications

References 56 publications

Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Spatial and temporal dynamics of microbiomes and resistomes in broiler litter stockpiles

The Fate of Foodborne Pathogens in Manure Treated Soil

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