Assessing the benefit of the 72-hour antibiotic therapy reassessment documentation

Perut, V.; Gauzit, R.; Kernéis, Solen; Canouï, Etienne; Chedhomme, François-Xavier; Batista, Rui; Conort, O.; Bouam, Samir; Raymond, J.; Chevallier, A.; Salmon‐Céron, Dominique

doi:10.1016/j.medmal.2018.10.002

Cited by 4 publications

(8 citation statements)

References 15 publications

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“…were the most grama positive pathogen isolated from the specimens. The study by V. Pérut et al 21 in the hospitalized patients, including all wards, the pathogenic spectrum was similar to our audit (e coli 27%, klebsiella sps. (10%) and staphylococcus sps.…”

Section: Discussionsupporting

confidence: 90%

“…major advantages of this practice lie in increased chances of identifying the causative organism in sepsis and, more importantly, deescalating antibiotics to ones that directly address the organism. Hence microbiological culture reports guide the physicians for implementing appropriate de-escalation 21 . world-wide de-escalation rates have widely varied between 20 and 70 percent among the reports, and till now there is no bench mark rate, derived at, or recommended for it 2,4.…”

Section: Introductionmentioning

confidence: 99%

“…Major health care facilities in India have in house AMS programmes, yet there is a huge lag in monitoring and reporting the effectiveness of these programmes 23 . The monitoring, auditing, and reporting the usage of broad-spectrum antibiotics helps to identify the rates and reasons for inappropriate use along with the reasons for non-de-escalation in appropriate circumstances 21,22 . Hence, we did a clinical audit in our center to estimate the de-escalation rates of empirical broadspectrum antibiotics and identify possible reasons for non-deescalation.…”

Section: Introductionmentioning

confidence: 99%

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De-Escalation of Broad-Spectrum Antibiotics After Relevant Culture Reports in Medical Ward Patients Audit from A Tertiary Care Hospital in South India

2022

Int J Life Sci Pharm Res

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Prolonged and improper usage of antibiotics has been shown as a main reason for the emergence of multidrug-resistant pathogens.Antimicrobial stewardship (AMS) programs have been shown to reduce the antibiotics usage and the rate of emergence of resistance. De-escalation of antimicrobials is an important component of AMS. AMS programmes require regular auditing and feedback for proper implementation and continuous improvement. Hence we did this clinical audit with the main aim of estimating the de-escalation rates and identifying the possible reasons for non-de-escalation in our centre. Case sheets of the patients admitted between 1st October 2020 to 31st December 2020 were screened during discharge for data for de-escalation and reasons for non-de-escalation. Cefeprazone-sulbactum (32%) was commonly used empirical monotherapy in the audited period. De-escalation rate after positive culture reposts was 28%. Serious clinical illness (36%) was found to be the most common reason for non-de-escalation. De-escalation was not done in nearly 25% of eligible instances without a proper justification.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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De-Escalation of Broad-Spectrum Antibiotics After Relevant Culture Reports in Medical Ward Patients Audit from A Tertiary Care Hospital in South India

2022

Int J Life Sci Pharm Res

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“…Using AOFs was not likely to improve deescalation. In a French study by Pérut et al (2019), 44% of antibiotic therapies with a broad spectrum on day 1 benefited from a de-escalation at 72 hours, which was higher in this study. Pérut et al concluded that clearly recorded reassessment at 72 hours was associated with de-escalation (p = 0.025).…”

Section: Prescribing Patterns For the Patient With Community-acquired...contrasting

confidence: 53%

“…The guidelines state that antibiotic therapy should be reassessed between 48 and 72 hours after treatment initiation in order to narrow the spectrum of antibiotics if possible (Pérut et al, 2019). Using AOFs was not likely to improve deescalation.…”

Section: Prescribing Patterns For the Patient With Community-acquired...mentioning

confidence: 99%

The use of an antibiotic order form in a tertiary hospital: Influence on physicians’ prescribing patterns

Vo¹,

Anh²,

Nguyen³

et al. 2021

J Pharm Pharmacogn Res

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Context: Vietnam is one of the countries at the high alert of antibiotic resistance. Aims: To evaluate the compliance rate and changes in physicians’ prescribing patterns in patients with community-acquired pneumonia (CAP) before and after using the antibiotic order form (AOF) in a tertiary hospital. Methods: 120 inpatient medical records having antibiotic use and 115 patient medical records diagnosed with CAP at a Department of Respiratory Medicine during 3 months before and 3 months after using the AOF were retrospectively collected for assessment. Results: The compliance rate was 92%, and the average rate of filling in information fields was 58%. Comparison of prescribing behavior of CAP in control and intervention group showed that the rate of bacterial culture increased from 70% to 77% (p = 0.690), in which the rate of culture prior prescribing administration increased from 14% to 45% (p < 0.001), the initial antibiotic regimen with narrow-spectrum increased from 26% to 36% (p = 0.353), the proportion of patients improved clinically after 72 hours increased from 64% to 89% (p = 0.138), and the de-escalation decreased from 23% to 20% (p = 0.713). The treatment failure at hospital discharge decreased from 12% to 6% (p = 0.447). However, the length of treatment and the days of antibiotic treatment were not significantly different. Conclusions: The compliance rate was high, but the AOF filling rate was incomplete. Improving prescribing patterns and treatment efficacy in CAP patients is a suggestion to combine the AOF into multifaceted interventional efforts for specific patients.

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Amélioration de l’adéquation des antibiothérapies aux recommandations et de leur réévaluation par une action pluridisciplinaire : étude prospective dans un service de médecine interne

Ourghanlian

Caruba

Facchin

et al. 2020

La Revue de Médecine Interne

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Assessing the benefit of the 72-hour antibiotic therapy reassessment documentation

Cited by 4 publications

References 15 publications

De-Escalation of Broad-Spectrum Antibiotics After Relevant Culture Reports in Medical Ward Patients Audit from A Tertiary Care Hospital in South India

De-Escalation of Broad-Spectrum Antibiotics After Relevant Culture Reports in Medical Ward Patients Audit from A Tertiary Care Hospital in South India

The use of an antibiotic order form in a tertiary hospital: Influence on physicians’ prescribing patterns

Amélioration de l’adéquation des antibiothérapies aux recommandations et de leur réévaluation par une action pluridisciplinaire : étude prospective dans un service de médecine interne

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