Assessing the anti-tumour properties of Iraqi propolis in vitro and in vivo

Sulaiman, Ghassan M.; Ad’hiah, Ali H.; Al-Sammarrae, Khulood W.; Bagnati, Renzo; Frapolli, Roberta; Bello, Ezia; Uboldi, Sarah; Romano, Michela; Panini, Nicolò; Scanziani, Eugenio; Pezzolato, Marzia; Erba, Eugenio; D’Incalci, Maurizio

doi:10.1016/j.fct.2012.01.022

Cited by 33 publications

(32 citation statements)

References 47 publications

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“…Moroccan propolis extracts (ethanolic and ethyl acetate) were described as exerting antiproliferative effect against BSR (hamster renal adenocarcinoma), Hep-2 (Human laryngeal carcinoma), and P815 (murine mastocytoma) in dose-dependent manner [29]. Similar results were obtained by Sulaiman et al [30] with Iraqi propolis, who described the inhibitory effects against the proliferation of HL-60 and colony potential of HCT116 cells.…”

Section: Discussionsupporting

confidence: 53%

Cytotoxicity of Portuguese Propolis: The Proximity of theIn VitroDoses for Tumor and Normal Cell Lines

Calhelha

Falcão

Queiroz

et al. 2014

BioMed Research International

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With a complex chemical composition rich in phenolic compounds, propolis (resinous substance collected by Apis mellifera from various tree buds) exhibits a broad spectrum of biological activities. Recently, in vitro and in vivo data suggest that propolis has anticancer properties, but is the cytoxicity of propolis specific for tumor cells? To answer this question, the cytotoxicity of phenolic extracts from Portuguese propolis of different origins was evaluated using human tumor cell lines (MCF7—breast adenocarcinoma, NCI-H460—non-small cell lung carcinoma, HCT15—colon carcinoma, HeLa—cervical carcinoma, and HepG2—hepatocellular carcinoma), and non-tumor primary cells (PLP2). The studied propolis presented high cytotoxic potential for human tumor cell lines, mostly for HCT15. Nevertheless, excluding HCT15 cell line, the extracts at the GI50 obtained for tumor cell lines showed, in general, cytotoxicity for normal cells (PLP2). Propolis phenolic extracts comprise phytochemicals that should be further studied for their bioactive properties against human colon carcinoma. In the other cases, the proximity of the in vitro cytotoxic doses for tumor and normal cell lines should be confirmed by in vivo tests and may highlight the need for selection of specific compounds within the propolis extract.

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Section: Discussionsupporting

confidence: 53%

Cytotoxicity of Portuguese Propolis: The Proximity of theIn VitroDoses for Tumor and Normal Cell Lines

Calhelha

Falcão

Queiroz

et al. 2014

BioMed Research International

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“…CAPE was also shown to inhibit the proliferation of the colorectal cell line SW480 by decreasing the β-catenin, c-myc and cyclin D1 expression (He et al, 2006). Sulaiman et al (2012) showed that Iraqi propolis promotes HL-60 cells apoptosis by down-regulating Bcl-2 proteins and activating Bax proteins.…”

Section: Discussionmentioning

confidence: 99%

Antitumoural and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models

Silva-Carvalho

Miranda-Gonçalves

Ferreira

et al. 2014

Journal of Functional Foods

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A B S T R A C T Propolis, a natural product, has important biological properties, however, studies with Portuguese propolis are scarce. Thus, we aimed to characterize the chemical composition and the antitumoural and antiangiogenic activities of a sample from Pereiro (Portugal). The chemical profile of our propolis sample (P10.EE) is similar to the poplar propolis type. P10.EE decreased cell viability of different tumour cells, being less cytotoxic against non-tumoural cells. P10.EE decreased MDA-MB-231 and DU145 cell proliferation and migration, with cell cycle changes and increased cell death. The increased glucose consumption and lactate production in MDA-MB-231 cells is explained by an increased expression of different metabolism-related proteins. P10.EE induced a decrease in HBMEC cells total biomass and proliferation and decreased vessel sprouting in the chicken chorioallantoic membrane. Additionally, P10.EE potentiates paclitaxel effect in MDA-MB-231 and DU145 cells. Concluding, P10.EE can be a good candidate for cancer drug development since it affects different characteristics that dictate tumorigenesis.

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“…Water-extracted propolis (WEP) is reported to exert a chemopreventive effect on rat urinary bladder carcinogenesis (Dornelas et al, 2012a(Dornelas et al, , 2012b. Ethanol-extracted propolis (EEP), obtained by extraction with 70% ethanol, is reported to exhibit antibacterial (Righi et al, 2011), antifungal (Siqueira et al, 2009), antioxidant (Righi et al, 2011) and anticarcinogenic (Valente et al, 2011;Sulaiman et al, 2012) activities. Because of these reported effects, propolis is used for medical, dietetic and cosmetic purposes.…”

Section: Introductionmentioning

confidence: 99%

Ethanol-extracted propolis enhances BBN-initiated urinary bladder carcinogenesis via non-mutagenic mechanisms in rats

Xie

Fujioka

et al. 2015

Food and Chemical Toxicology

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Assessing the anti-tumour properties of Iraqi propolis in vitro and in vivo

Cited by 33 publications

References 47 publications

Cytotoxicity of Portuguese Propolis: The Proximity of theIn VitroDoses for Tumor and Normal Cell Lines

Cytotoxicity of Portuguese Propolis: The Proximity of theIn VitroDoses for Tumor and Normal Cell Lines

Antitumoural and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models

Ethanol-extracted propolis enhances BBN-initiated urinary bladder carcinogenesis via non-mutagenic mechanisms in rats

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