Assessing the activity of benzodioxol, phenol and aniline derivatives as radical trapping antioxidants that inhibit ferroptosis
Helene B. E. Schricker,
Mohamed M. Mouzayek,
Jonas Wanninger
et al.
Abstract:A small molecule screen has identified a benzodioxol anilide as a ferroptosis inhibitor. To determine the structure-activity relationship (SAR) of this compound class, we have synthesized a library of 35 derivatives followed by testing their ability to inhibit cell death that was induced via RSL3, an inhibitor of the main ferroptosis regulator glutathione peroxidase 4 (GPX4), in the mouse embryonic fibroblast cell line Pfa-1. Choosing 12 representative structures, rescue experiments were performed following th… Show more
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