Assessing surgical methods for treatment of cubital tunnel syndrome - which is the best?

Burtt, Karen E.; Badash, Ido; Wu, Brian

doi:10.4103/2542-4157.213700

Cited by 5 publications

(2 citation statements)

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“…Although stringent methodological criteria have been sufficiently fulfilled in both of the study protocol & the commentary article, 1,2 besides that the study protocol has been designed to permit randomized allocation of participants, which is often considered the gold standard for a clinical trial; however, surgeons increasingly recognized the limitations of a randomized clinical trial, where there are inevitable number of variables that are not amenable for randomization such as, each patient had unique baseline findings, each surgeon had different skills, and each operation involved countless choices about anesthesia, premedication, surgical approach, instrumentation, and postoperative care, all of which challenged the notion that clinical trials are insistently required. 3 As a critical appraisal for the clinical trial study protocol of Liu et al, 1 potential areas of improvement of the protocol could enhance the study yield, mostly from the statistical analysis point of view still remains.…”

Section: Commentarymentioning

confidence: 99%

Evaluation of surgical methods for treatment of cubital tunnel syndrome - statistical perspectives

Mohammed¹

2017

Clin Trials Orthop Disord

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International audienceThis commentary addresses strengths and weaknesses of the clinical trial study protocol designed by Liu et al., in particular with regard of the methodology, taking into consideration the commentary article "Assessing surgical methods for treatment of cubital tunnel syndrome - which is the best?" Our commentary emphasizes the importance of adjustment for known prognostic covariates, such as duration of symptoms and advanced age that have been negatively correlated with outcomes in previous studies. Subgroup analysis for the treatment groups of interest, namely moderate and severe cubital tunnel syndrome, which have previously shown conflicting differences in efficacy of surgical options is highly recommended. Intention-to-treat analysis is a preferable approach for the evaluation of primary outcome measures to lessen the bias. Use of well-validated composite outcome measure is strongly encouraged

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Section: Commentarymentioning

confidence: 99%

Evaluation of surgical methods for treatment of cubital tunnel syndrome - statistical perspectives

Mohammed¹

2017

Clin Trials Orthop Disord

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“…Peripheral nerve injuries (PNIs) are often multifaceted and present various degrees of severity, potential ischemia, tissue deficits, etc. [1,2] In many cases, treatment of the nerve injury is delayed for several weeks to handle more immediate concerns of vascular and orthopedic stabilization, and the prevention of infections. [3,4] Delaying PNI treatment, however, can result in severe long-term consequences.…”

Section: Introductionmentioning

confidence: 99%

Nanochannel‐Based Poration Drives Benign and Effective Nonviral Gene Delivery to Peripheral Nerve Tissue

et al. 2020

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While gene and cell therapies have emerged as promising treatment strategies for various neurological conditions, heavy reliance on viral vectors can hamper widespread clinical implementation. Here, the use of tissue nanotransfection as a platform nanotechnology to drive nonviral gene delivery to nerve tissue via nanochannels, in an effective, controlled, and benign manner is explored. TNT facilitates plasmid DNA delivery to the sciatic nerve of mice in a voltage‐dependent manner. Compared to standard bulk electroporation (BEP), impairment in toe‐spread and pinprick response is not caused by TNT, and has limited to no impact on electrophysiological parameters. BEP, however, induces significant nerve damage and increases macrophage immunoreactivity. TNT is subsequently used to deliver vasculogenic cell therapies to crushed nerves via delivery of reprogramming factor genes Etv2, Foxc2, and Fli1 (EFF). The results indicate the TNT‐based delivery of EFF in a sciatic nerve crush model leads to increased vascularity, reduced macrophage infiltration, and improved recovery in electrophysiological parameters compared to crushed nerves that are TNT‐treated with sham/empty plasmids. Altogether, the results indicate that TNT can be a powerful platform nanotechnology for localized nonviral gene delivery to nerve tissue, in vivo, and the deployment of reprogramming‐based cell therapies for nerve repair/regeneration.

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Role of macrophages in peripheral nerve injury and repair

et al. 2019

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Resident and inflammatory macrophages are essential effectors of the innate immune system. These cells provide innate immune defenses and regulate tissue and organ homeostasis. In addition to their roles in diseases such as cancer, obesity and osteoarthritis, they play vital roles in tissue repair and disease rehabilitation. Macrophages and other inflammatory cells are recruited to tissue injury sites where they promote changes in the microenvironment. Among the inflammatory cell types, only macrophages have both pro-inflammatory (M1) and anti-inflammatory (M2) actions, and M2 macrophages have four subtypes. The co-action of M1 and M2 subtypes can create a favorable microenvironment, releasing cytokines for damaged tissue repair. In this review, we discuss the activation of macrophages and their roles in severe peripheral nerve injury. We also describe the therapeutic potential of macrophages in nerve tissue engineering treatment and highlight approaches for enhancing M2 cell-mediated nerve repair and regeneration.

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Assessing surgical methods for treatment of cubital tunnel syndrome - which is the best?

Cited by 5 publications

References 0 publications

Evaluation of surgical methods for treatment of cubital tunnel syndrome - statistical perspectives

Evaluation of surgical methods for treatment of cubital tunnel syndrome - statistical perspectives

Nanochannel‐Based Poration Drives Benign and Effective Nonviral Gene Delivery to Peripheral Nerve Tissue

Role of macrophages in peripheral nerve injury and repair

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