Assessing severity of epilepsy in children: Preliminary evidence of validity and reliability of a single-item scale

Speechley, Kathy N.; Sang, Xuelian; Levin, Simon; Zou, Guang Yong; Eliasziw, Michael; Smith, Mary Lou; Camfield, Carol; Wiebe, Samuel

doi:10.1016/j.yebeh.2008.05.001

Cited by 59 publications

(60 citation statements)

References 42 publications

(41 reference statements)

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“…Neurologists reported on types of seizures and of epilepsy syndrome, frequency of seizures, and medication and adverse effects and classified severity of epilepsy, using the Global Assessment of Severity of Epilepsy (GASE) 13 to rate overall severity on a scale from 1 (extremely severe) to 7 (not at all severe). GASE has adequate content, convergent, and construct validity and high intra-and interrater reliability.…”

Section: Epilepsy Characteristicsmentioning

confidence: 99%

“…GASE has adequate content, convergent, and construct validity and high intra-and interrater reliability. 13 They also rated comorbidities using single items adapted from previous studies, 14 specifically, any behavior (0 ϭ none to 3 ϭ severe) or cognitive problems (0 ϭ none to 4 ϭ severe). The classifications of the International League Against Epilepsy 15,16 guided the categorization of neurologists' reports of epilepsy/epilepsy syndrome types.…”

Section: Epilepsy Characteristicsmentioning

confidence: 99%

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Quality of life in children with new-onset epilepsy

et al. 2012

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Objectives:To assess health-related quality of life (HRQL) over 2 years in children 4Ϫ12 years old with new-onset epilepsy and risk factors.Methods: Data are from a multicenter prospective cohort study, the Health-Related Quality of Life Study in Children with Epilepsy Study (HERQULES). Parents reported on children's HRQL and family factors and neurologists on clinical characteristics 4 times. Mean subscale and summary scores were computed for HRQL. Individual growth curve models identified trajectories of change in HRQL scores. Multiple regression identified baseline risk factors for HRQL 2 years later.Results: A total of 374 (82%) questionnaires were returned postdiagnosis and 283 (62%) of eligible parents completed all 4. Growth rates for HRQL summary scores were most rapid during the first 6 months and then stabilized. About one-half experienced clinically meaningful improvements in HRQL, one-third maintained their same level, and one-fifth declined. Compared with the general population, at 2 years our sample scored significantly lower on one-third of CHQ subscales and the psychosocial summary. After controlling for baseline HRQL, cognitive problems, poor family functioning, and high family demands were risk factors for poor HRQL 2 years later. Conclusions:On average, HRQL was relatively good but with highly variable individual trajectories. At least one-half did not experience clinically meaningful improvements or declined over 2 years. Cognitive problems were the strongest risk factor for compromised HRQL 2 years after diagnosis and may be largely responsible for declines in the HRQL of children newly diagnosed with epilepsy. Neurology The primary goal in managing epilepsy is to optimize patients' health-related quality of life (HRQL) by affording them a lifestyle as free as possible from the medical and psychosocial sequelae of seizures.1,2 Empirical evidence of the natural course of HRQL and associated risk factors is an essential step toward providing prognostic information to patients and families and determining key factors along the causal pathway that may be amenable to interventions to mute the potential negative effects of epilepsy on HRQL. Most empirical assessments of HRQL in children with epilepsy (CWE) have focused on a specific aspect of HRQL (e.g., psychological well-being, social competence, or behavior). Of the comprehensive, multidimensional assessments of HRQL in children, most had small samples and focused on selected subgroups such as adolescents, 3,4 children with intractable/refractory epilepsy, 5,6 or childrenFrom the

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Section: Epilepsy Characteristicsmentioning

confidence: 99%

Section: Epilepsy Characteristicsmentioning

confidence: 99%

Quality of life in children with new-onset epilepsy

et al. 2012

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“…Epilepsy Characteristics: Pediatric neurologists completed the Global Assessment of Severity of Epilepsy (GASE), a single-item, seven-point global rating scale (1 = extremely severe to 7 = not at all severe) designed for neurologists to assess the overall severity of epilepsy in children, taking into account all aspects of the patient's epilepsy [31]. The GASE demonstrated minimum burden on participants, adequate content, convergent, and construct validity, and high intra-and inter-rater reliability [31].…”

Section: Neurologist Reportmentioning

confidence: 99%

“…The GASE demonstrated minimum burden on participants, adequate content, convergent, and construct validity, and high intra-and inter-rater reliability [31]. Pediatric neurologists assessed the extent to which epilepsy interferes with daily activities on a 7-point scale (1 = none to 7 = severe).…”

Section: Neurologist Reportmentioning

confidence: 99%

Do depressive symptoms affect mothers’ reports of child outcomes in children with new-onset epilepsy?

et al. 2010

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“…18 Neurologists also reported on seizure type (generalized; localization-related [partial]; partial onset, secondary generalization; undetermined) and frequency (7-point scale ranging from "not at all frequent" to "extremely frequent" since the last clinic visit), age at onset, and medication information (number of antiepileptic drugs, side effects). Lower scores indicate more severe epilepsy.…”

mentioning

confidence: 99%