Assessing serum C-reactive protein as a predictor of COVID-19 outcomes: a retrospective cross-sectional study

Abstract

Background: Despite being very infectious and fatal, the coronavirus disease 2019 (COVID-19) lacks a reliable and practical biomarker to assess how serious it will be. Aim: The current study aims to conclude the possibility of C-reactive protein (CRP) level serving as a biomarker for early prediction of COVID-19 infections. Methods: In this retrospective cross-sectional study, 88 people participated who were infected with COVID-19, aged from 25 to 79 years old. Compare the CRP test range of all samples from patients who visited the hospital between January and April 2022. Results: All participants were confirmed to have COVID-19 through nasopharyngeal swab analysis and real-time polymerase chain reaction real-time polymerase chain reaction testing. Results showed that the majority of infected individuals had elevated CRP levels. A P-value of less than 0.05 indicated a significant difference in CRP levels between alive and dead patients. No significant difference in CRP levels was found between male and female patients. The average CRP level of deceased patients was 137.79 mg/l, while the average CRP level of survivors was 14.37 mg/l. The median interquartile range of deceased patients was also found to be significantly higher compared to survivors. Conclusion: In conclusion, serum CRP levels potentially predict the severity and development of sickness in patients with COVID-19 infections.

Clinical Features and Prognostic Predictors in Patients with Renal Transplant Complicated by SARS-CoV-2 Infection, a Retrospective Single-Center Study

“…Elevated CRP levels have been widely recognized as markers of inflammation and have been linked to poor outcomes in various infectious diseases, including COVID-19. 31,32 In the context of kidney transplant recipients, the heightened inflammatory response indicated by rising CRP levels may reflect a combination of viral pathogenicity and the unique immunological landscape of these patients, which could exacerbate disease severity. 33,34 Moreover, the identification of CRP levels on the 3rd and 7th day as independent risk factors for mortality provides valuable insights for clinical management.…”