Assessing safety and success after using bevacizumab, 5-fluorouracil or placebo in primary trabeculectomy. A prospective randomized placebo controlled 1-year follow-up study

Kandarakis, Stylianos; Kontaxakis, Anastasios; Doumazos, Leonidas; Petrou, Petros; Droutsas, Konstantinos; Papaconstantinou, Demetrios; Georgalas, Ilias

doi:10.1080/15569527.2021.2003376

Cited by 2 publications

(2 citation statements)

References 50 publications

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“…As a potent inducer of angiogenesis, VEGF also promotes the early migration of inflammatory cells and fibroblasts. Studies on various isoforms of VEGF show that VEGF165 and VEGF121 predominantly affect blood vessel growth, whereas VEGF189 is more critical to fibrosis [ 23 ]. Bevacizumab, injected intravitreally, is used off-label to treat the neovascular macular degeneration and vascular diseases of the retina characterized by an edematous and exudative component, such as diabetic retinopathy and central retinal vein occlusion.…”

Section: Monoclonal Antibodiesmentioning

confidence: 99%

Pharmacological Approaches to Modulate the Scarring Process after Glaucoma Surgery

Collotta,

Colletta,

Carlucci

et al. 2023

Pharmaceuticals

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Glaucoma is an acquired optic neuropathy that results in a characteristic optic nerve head appearance and visual field loss. Reducing the IOP is the only factor that can be modified, and the progression of the disease can be managed through medication, laser treatment, or surgery. Filtering procedures are used when target pressure cannot be obtained with less invasive methods. Nevertheless, these procedures require accurate control of the fibrotic process, which can hamper filtration, thus, negatively affecting the surgical success. This review explores the available and potential pharmacological treatments that modulate the scarring process after glaucoma surgery, analyzing the most critical evidence available in the literature. The modulation of scarring is based on non-steroidal anti-inflammatory drugs (NSAIDs), mitomycin, and 5-fluorouracil. In the long term, the failure rate of filtering surgery is mainly due to the limitations of the current strategies caused by the complexity of the fibrotic process and the pharmacological and toxicological aspects of the drugs that are currently in use. Considering these limitations, new potential treatments were investigated. This review suggests that a better approach to tackle the fibrotic process may be to hit multiple targets, thus increasing the inhibitory potential against excessive scarring following surgery.

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Section: Monoclonal Antibodiesmentioning

confidence: 99%

Pharmacological Approaches to Modulate the Scarring Process after Glaucoma Surgery

Collotta,

Colletta,

Carlucci

et al. 2023

Pharmaceuticals

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show abstract

“…Regarding bleb leakage, it has been categorized into early- and late-onset leak [ 29 ]. Early bleb leaks tend to occur when the bleb is inferiorly located, when MMC has been applied and after suture lysis or needling procedures [ 31 , 32 ]. Comparing early bleb leakage with late-onset leakage, the latter is regarded as the most important risk factor for BRIs [ 5 ].…”

Section: Thin and Leaking Blebmentioning

confidence: 99%

A Review on Pathogens and Necessary Diagnostic Work for Bleb-Related Infections (BRIs)

et al. 2022

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At the present time, as newer techniques and minimally invasive procedures gain popularity among anterior segment surgeons for regulating intraocular pressure, trabeculectomy still has a leading role in glaucoma surgery. Trabeculectomy retains a highly successful and safe profile; however, one of the major complications includes bleb-related infections (BRIs). To date, the most common pathogens remain Gram-positive cocci, but the list of pathogens that have been identified in the literature includes more than 100 microorganisms. Because antibiotic use is more widespread than ever before and our ability to identify pathogens has improved, the pathogen spectrum will broaden in the future and more pathogens causing BRIs will be described as atypical presentations. The scope of this review was to identify all pathogens that have been described to cause bleb-related infections to date, as well as focus on the risk factors, clinical presentation, and various available diagnostic tools used for an appropriate diagnostic workup.

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Assessing safety and success after using bevacizumab, 5-fluorouracil or placebo in primary trabeculectomy. A prospective randomized placebo controlled 1-year follow-up study

Cited by 2 publications

References 50 publications

Pharmacological Approaches to Modulate the Scarring Process after Glaucoma Surgery

Pharmacological Approaches to Modulate the Scarring Process after Glaucoma Surgery

A Review on Pathogens and Necessary Diagnostic Work for Bleb-Related Infections (BRIs)

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