Assessing Resource Demands during Sentence Processing in Parkinson's Disease

Grossman, Murray; Lee, Christine; Morris, Jennifer; Stern, Matthew B.; Hurtig, Howard I.

doi:10.1006/brln.2001.2630

Cited by 86 publications

(56 citation statements)

References 44 publications

(66 reference statements)

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“…A more general impairment of inhibition following striatal dysfunction is also suggested by Grossman et al (2002) who measured comprehension of complex syntax and processing speed for planning and inhibition in people with PD. They found a significant correlation between these two measures.…”

Section: Language Processing In Individuals With Damage To the Basal mentioning

confidence: 83%

The basal ganglia circuits, dopamine, and ambiguous word processing: A neurobiological account of priming studies in Parkinson's disease

Chenery

Angwin

Copland

2008

J Inter Neuropsych Soc

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Research into the processing of lexical ambiguities has provided a valuable paradigm for investigating the functional architecture of the language processing system in normal and neurologically impaired populations and specifically, how basal ganglia circuits and the neurotransmitter dopamine may act to enhance and0or suppress various meanings relative to the context in which the lexical ambiguity appears. In this review, we develop the hypothesis that an integrated basal ganglia thalamocortical circuit linking the striatum and inferior frontal cortex is involved in the enhancement and suppression of ambiguous word meanings when a lexical ambiguity is presented within a linguistic context. Reference to behavioral, neurophysiological, and neurochemical studies of subcortical function in both healthy populations and people with Parkinson's disease will be used to provide further support for the proposal that the subcortex is integrally involved in ambiguous word processing. (JINS, 2008, 14, 351-364.)

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Section: Language Processing In Individuals With Damage To the Basal mentioning

confidence: 83%

The basal ganglia circuits, dopamine, and ambiguous word processing: A neurobiological account of priming studies in Parkinson's disease

Chenery

Angwin

Copland

2008

J Inter Neuropsych Soc

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“…Although PD is traditionally considered a movement disorder, multiple studies have reported cognitive changes, including impairments in executive function, language, memory, vision, and psychomotor speed (Grossman et al, 2002;Lee et al, 2003;Pillon et al, 2003;Muslimovic et al, 2005). fMRI studies and positron emission tomography (PET) activation studies have indicated that changes in the recruitment of the frontal-striatal-thalamic circuitry may explain such cognitive difficulties (Owen et al, 1998;Grossman et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Cognition following bilateral deep brain stimulation surgery of the subthalamic nucleus for Parkinson's disease

Halpern

Rick

Danish

et al. 2008

Int J Geriat Psychiatry

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“…The hallmark of PD is a dysfunction of this frontal-striatal loop due to partial depletion of the neurotransmitter dopamine. PD deficit in syntactic complexity, such as OR clause comprehension, correlates with deficits in executive tasks such as the Stroop task (Grossman, Lee, Morris, Stern, & Hurtig, 2002) and set switching tasks (Hochstadt, Nakano, Lieberman, & Friedman, 2006). 6 The effects of syntactic complexity and working memory maintenance in PD were explored in an fMRI study using a factorial design (Grossman et al, 2003).…”

Section:  Coordinating Information In Relative Clauses: a Role For mentioning

confidence: 99%

Cognitive and neural underpinnings of syntactic complexity

Fernandez-Duque

2009

Syntactic Complexity

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Based on a review of the neuroimaging literature, I argue that the resources allocated for processing syntactically complex sentences (i.e., object-extracted relative clauses) are domain-general. Overlapping brain areas are activated by OR clauses and by effortful executive tasks such as storing information in verbal working memory, resolving conflict among competing representations, and switching one's mindset. A re-conceptualization of 'syntactic complexity' in terms of executive functions provides a useful framework in which to explore its links to relational complexity and to cognitive neuroscience. As such, this approach should prove useful to linguists and cognitive scientists alike.

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Assessing Resource Demands during Sentence Processing in Parkinson's Disease

Cited by 86 publications

References 44 publications

The basal ganglia circuits, dopamine, and ambiguous word processing: A neurobiological account of priming studies in Parkinson's disease

The basal ganglia circuits, dopamine, and ambiguous word processing: A neurobiological account of priming studies in Parkinson's disease

Cognition following bilateral deep brain stimulation surgery of the subthalamic nucleus for Parkinson's disease

Cognitive and neural underpinnings of syntactic complexity

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